{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:59:42Z","timestamp":1791377982812,"version":"4.3.2"},"reference-count":176,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The relationship between migraines and allergies is controversial. Though they are epidemiologically linked, the underlying pathophysiological connection between them remains unclear. Migraines and allergic disorders have various underlying genetic and biological causes. As per the literature, these conditions are epidemiologically linked, and some common pathophysiological pathways have been hypothesized. The histaminergic system may be the clue to understanding the correlation among these diseases. As a neurotransmitter in the central nervous system with a vasodilatory effect, histamine has a well-documented influence on the allergic response and could be involved in the pathophysiology of migraines. Histamine may influence hypothalamic activity, which may play a major role in migraines or may simply influence their severity. In both cases, antihistamine drugs could prove useful. This review examines whether the histaminergic system, particularly H3 and H4 receptors, may provide a mechanistic link between the pathophysiology of migraines and allergic disorders, two common and debilitating conditions. Identifying their connection could help identify novel therapeutic strategies.<\/jats:p>","DOI":"10.3390\/jcm12103566","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T10:08:55Z","timestamp":1684490935000},"page":"3566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Migraine, Allergy, and Histamine: Is There a Link?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-9299","authenticated-orcid":false,"given":"Alessandro","family":"Ferretti","sequence":"first","affiliation":[{"name":"Pediatrics Unit, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Gatto","sequence":"additional","affiliation":[{"name":"Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University of Rome, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Velardi","sequence":"additional","affiliation":[{"name":"General and Emergency Department, Bambino Ges\u00f9 Children\u2019s Hospital, Istituto di Ricerca e Cura a Carattere Scientifico, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-7758","authenticated-orcid":false,"given":"Giovanni","family":"Di Nardo","sequence":"additional","affiliation":[{"name":"Pediatrics Unit, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Foiadelli","sequence":"additional","affiliation":[{"name":"Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-2876","authenticated-orcid":false,"given":"Gianluca","family":"Terrin","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Gynecological and Urological Sciences, Faculty of Medicine and Dentistry, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Cecili","sequence":"additional","affiliation":[{"name":"Pediatrics Unit, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-2038","authenticated-orcid":false,"given":"Umberto","family":"Raucci","sequence":"additional","affiliation":[{"name":"General and Emergency Department, Bambino Ges\u00f9 Children\u2019s Hospital, Istituto di Ricerca e Cura a Carattere Scientifico, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6602-103X","authenticated-orcid":false,"given":"Massimiliano","family":"Valeriani","sequence":"additional","affiliation":[{"name":"Developmental Neurology Unit, Bambino Ges\u00f9 Children\u2019s Hospital, Istituto di Ricerca e Cura a Carattere Scientifico, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-8120","authenticated-orcid":false,"given":"Pasquale","family":"Parisi","sequence":"additional","affiliation":[{"name":"Pediatrics Unit, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1001\/jama.1927.02680440017006","article-title":"Allergic Migraine","volume":"88","author":"Vaughan","year":"1927","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41572-020-00227-0","article-title":"Allergic Rhinitis","volume":"6","author":"Bousquet","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and Its Impact on Asthma (ARIA) 2008 Update (in Collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1056\/NEJMcp1412282","article-title":"Clinical Practice. Allergic Rhinitis","volume":"372","author":"Wheatley","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/S0140-6736(11)60130-X","article-title":"Allergic Rhinitis","volume":"378","author":"Greiner","year":"2011","journal-title":"Lancet"},{"key":"ref_6","first-page":"437","article-title":"Burden and Socioeconomics of Asthma, Allergic Rhinitis, Atopic Dermatitis and Food Allergy","volume":"20","author":"Dierick","year":"2020","journal-title":"Expert. Rev. Pharm. Outcomes Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13223-020-00495-1","article-title":"Prevalence of Allergic Rhinitis, Related Comorbidities and Risk Factors in Schoolchildren","volume":"16","author":"Katona","year":"2020","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1468-2982.2007.01288.x","article-title":"The Global Burden of Headache: A Documentation of Headache Prevalence and Disability Worldwide","volume":"27","author":"Stovner","year":"2007","journal-title":"Cephalalgia"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s10194-016-0699-5","article-title":"GBD 2015: Migraine Is the Third Cause of Disability in under 50s","volume":"17","author":"Steiner","year":"2016","journal-title":"J. Headache Pain"},{"key":"ref_10","unstructured":"(2018). GBD 2016 Headache Collaborators Global, Regional, and National Burden of Migraine and Tension-Type Headache, 1990-2016: A Systematic Analysis for the Global Burden of Disease Study 2016. Lancet Neurol., 17, 954\u2013976."},{"key":"ref_11","unstructured":"(2020). GBD 2019 Diseases and Injuries Collaborators Global Burden of 369 Diseases and Injuries in 204 Countries and Territories, 1990-2019: A Systematic Analysis for the Global Burden of Disease Study 2019. Lancet, 396, 1204\u20131222."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41582-022-00763-1","article-title":"Global Epidemiology of Migraine and Its Implications for Public Health and Health Policy","volume":"19","author":"Steiner","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1398-9995.2008.01824.x","article-title":"Geographical Distribution of Atopic Rhinitis in the European Community Respiratory Health Survey I","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/cea.14239","article-title":"Allergic Diseases in India\u2014Prevalence, Risk Factors and Current Challenges","volume":"53","author":"Mahesh","year":"2023","journal-title":"Clin. Exp. Allergy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1067\/mai.2003.1484","article-title":"Is the Prevalence of Adult Asthma and Allergic Rhinitis Still Increasing? Results of an Italian Study","volume":"111","author":"Verlato","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/WCO.0000000000000439","article-title":"Co-Occurrence of Migraine and Atopy in Children and Adolescents: Myth or a Casual Relationship?","volume":"30","author":"Uluduz","year":"2017","journal-title":"Curr. Opin. Neurol."},{"key":"ref_17","first-page":"116","article-title":"Headache in Teenagers: Comorbidity and Prognosis","volume":"15 Suppl. 3","author":"Aro","year":"2000","journal-title":"Funct. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1468-2982.2005.01021.x","article-title":"The Relationship between Migraine and Atopic Disorders-the Contribution of Pulmonary Function Tests and Immunological Screening","volume":"26","author":"Ozge","year":"2006","journal-title":"Cephalalgia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jpeds.2012.01.040","article-title":"Physical Comorbidity of Migraine and Other Headaches in US Adolescents","volume":"161","author":"Lateef","year":"2012","journal-title":"J. Pediatr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/ped.12381","article-title":"Atopic Disorders Are More Common in Childhood Migraine and Correlated Headache Phenotype","volume":"56","author":"Ayta","year":"2014","journal-title":"Pediatr. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5152\/TurkThoracJ.2017.16008","article-title":"Presence of Headache and Migraine in Asthma Patients","volume":"18","author":"Turan","year":"2017","journal-title":"Turk. Thorac. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1177\/0333102416665870","article-title":"Comparison of Comorbidities of Migraine and Tension Headache in a Pediatric Headache Clinic","volume":"37","author":"Zolden","year":"2017","journal-title":"Cephalalgia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1111\/crj.12939","article-title":"Association between Asthma and Migraine: A Cross-Sectional Study of over 110 000 Adolescents","volume":"12","author":"Graif","year":"2018","journal-title":"Clin. Respir. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1136\/jim-2018-000715","article-title":"Children with Allergic Diseases Have an Increased Subsequent Risk of Migraine upon Reaching School Age","volume":"66","author":"Wei","year":"2018","journal-title":"J. Investig. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1111\/head.13966","article-title":"Demographics, Headache Features, and Comorbidity Profiles in Relation to Headache Frequency in People With Migraine: Results of the American Migraine Prevalence and Prevention (AMPP) Study","volume":"60","author":"Buse","year":"2020","journal-title":"Headache"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/pde.14607","article-title":"Association between Atopic Dermatitis and Headaches throughout Childhood and Adolescence-A Longitudinal Birth Cohort Study","volume":"38","author":"Manjunath","year":"2021","journal-title":"Pediatr. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4168\/aair.2023.15.1.55","article-title":"Atopic Disorders and Their Risks of Migraine: A Nationwide Population-Based Cohort Study","volume":"15","author":"Han","year":"2023","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_28","first-page":"723","article-title":"Association between Migraine and Asthma: Matched Case-Control Study","volume":"52","author":"Davey","year":"2002","journal-title":"Br. J. Gen. Pract."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1526-4610.2006.00597.x","article-title":"Is Headache Related to Asthma, Hay Fever, and Chronic Bronchitis? The Head-HUNT Study","volume":"47","author":"Aamodt","year":"2007","journal-title":"Headache"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/0883073808327831","article-title":"Headache in a National Sample of American Children: Prevalence and Comorbidity","volume":"24","author":"Lateef","year":"2009","journal-title":"J. Child. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10194-009-0176-5","article-title":"Population-Based Study of Migraine in Spanish Adults: Relation to Socio-Demographic Factors, Lifestyle and Co-Morbidity with Other Conditions","volume":"11","year":"2010","journal-title":"J. Headache Pain"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/pds.2233","article-title":"Comorbidities in an Asthma Population 8-29\u2009Years Old: A Study from the Norwegian Prescription Database","volume":"21","author":"Karlstad","year":"2012","journal-title":"Pharmacoepidemiol. Drug. Saf."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"858097","DOI":"10.1155\/2012\/858097","article-title":"Migraine-Asthma Comorbidity and Risk of Hypertensive Disorders of Pregnancy","volume":"2012","author":"Czerwinski","year":"2012","journal-title":"J. Pregnancy"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/head.12731","article-title":"Asthma Is a Risk Factor for New Onset Chronic Migraine: Results from the American Migraine Prevalence and Prevention Study","volume":"56","author":"Martin","year":"2016","journal-title":"Headache"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/crj.12623","article-title":"Association of Migraine with Asthma Risk: A Retrospective Population-Based Cohort Study","volume":"12","author":"Peng","year":"2018","journal-title":"Clin. Respir. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"18343","DOI":"10.1038\/s41598-019-54972-8","article-title":"Bidirectional Association between Asthma and Migraines in Adults: Two Longitudinal Follow-up Studies","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S1081-1206(10)60018-X","article-title":"Prevalence of Migraine Headaches in Patients with Allergic Rhinitis","volume":"97","author":"Ku","year":"2006","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s10194-006-0319-x","article-title":"Comorbidity in Finnish Migraine Families","volume":"7","author":"Artto","year":"2006","journal-title":"J. Headache Pain"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1526-4610.2010.01792.x","article-title":"Allergy and Immunotherapy: Are They Related to Migraine Headache?","volume":"51","author":"Martin","year":"2011","journal-title":"Headache"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2133.2006.07688.x","article-title":"Atopic Dermatitis in Adolescent Boys Is Associated with Greater Psychological Morbidity Compared with Girls of the Same Age: The Young-HUNT Study","volume":"156","author":"Saunes","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jaci.2015.07.020","article-title":"Association between Childhood Eczema and Headaches: An Analysis of 19 US Population-Based Studies","volume":"137","author":"Silverberg","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/pde.13084","article-title":"Atopic Dermatitis in Israeli Adolescents from 1998 to 2013: Trends in Time and Association with Migraine","volume":"34","author":"Hassidim","year":"2017","journal-title":"Pediatr. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/ced\/llac004","article-title":"Migraine among Adults with Atopic Dermatitis: A Cross-Sectional Study in the All of Us Research Programme","volume":"48","author":"Fan","year":"2023","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"908","DOI":"10.4065\/80.7.908","article-title":"Sinus Headache: A Neurology, Otolaryngology, Allergy, and Primary Care Consensus on Diagnosis and Treatment","volume":"80","author":"Cady","year":"2005","journal-title":"Mayo Clin. Proc."},{"key":"ref_45","unstructured":"(2018). Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd Edition. Cephalalgia, 38, 1\u2013211."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1001\/archinte.164.16.1769","article-title":"Prevalence of Migraine in Patients with a History of Self-Reported or Physician-Diagnosed \u201cSinus\u201d Headache","volume":"164","author":"Schreiber","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1526-4610.2006.00688.x","article-title":"The Sinus, Allergy and Migraine Study (SAMS)","volume":"47","author":"Eross","year":"2007","journal-title":"Headache"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.otohns.2004.01.005","article-title":"Nonrhinologic Headache in a Tertiary Rhinology Practice","volume":"130","author":"Perry","year":"2004","journal-title":"Otolaryngol. Head. Neck Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1526-4610.2007.00811.x","article-title":"Sinus CT Scan Findings in \u201cSinus Headache\u201d Migraineurs","volume":"48","author":"Mehle","year":"2008","journal-title":"Headache"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/01616412.2022.2156125","article-title":"Increased Visinin-like Protein-1, YKL-40, Lipocalin-2, and IL-23 Levels in Patients with Migraine","volume":"45","author":"Cafer","year":"2023","journal-title":"Neurol. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1526-4637.2009.00791.x","article-title":"Cytokine Polymorphism in Patients with Migraine: Some Suggestive Clues of Migraine and Inflammation","volume":"11","author":"Yilmaz","year":"2010","journal-title":"Pain Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1111\/j.1526-4610.2006.00485.x","article-title":"Mast Cell Involvement in the Pathophysiology of Migraine Headache: A Hypothesis","volume":"46","author":"Levy","year":"2006","journal-title":"Headache"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1046\/j.1468-2982.2001.00196.x","article-title":"Migraine and Function of the Immune System: A Meta-Analysis of Clinical Literature Published between 1966 and 1999","volume":"21","author":"Kemper","year":"2001","journal-title":"Cephalalgia"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s11882-012-0251-x","article-title":"Migraine and Allergy: A Review and Clinical Update","volume":"12","author":"Mehle","year":"2012","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/head.12293","article-title":"Histamine in Migraine and Brain","volume":"54","author":"Alstadhaug","year":"2014","journal-title":"Headache"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.1365-3083.2003.01216.x","article-title":"A Correlation between Migraine, Histamine and Immunoglobulin e","volume":"57","author":"Gazerani","year":"2003","journal-title":"Scand. J. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1526-4610.2006.00381.x","article-title":"Open-Label Trial of Cinnarizine in Migraine Prophylaxis","volume":"46","author":"Togha","year":"2006","journal-title":"Headache"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0021-8707(52)90007-5","article-title":"Migraine Is an Allergic Disease","volume":"23","author":"Unger","year":"1952","journal-title":"J. Allergy"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1034\/j.1399-3038.2002.01036.x","article-title":"Association of Asthma with Extra-Respiratory Symptoms in Schoolchildren: Two Cross-Sectional Studies 6 Years Apart","volume":"13","author":"Ronchetti","year":"2002","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1526-4610.2007.01030.x","article-title":"The Risk of Newly Diagnosed Asthma in Migraineurs with or without Previous Triptan Prescriptions","volume":"48","author":"Becker","year":"2008","journal-title":"Headache"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.pjnns.2018.07.004","article-title":"Which Came First, the Risk of Migraine or the Risk of Asthma? A Systematic Review","volume":"52","author":"Sayyah","year":"2018","journal-title":"Neurol. Neurochir. Pol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"741135","DOI":"10.3389\/falgy.2021.741135","article-title":"Association Between Asthma and Migraine: A Systematic Review and Meta-Analysis of Observational Studies","volume":"2","author":"Kang","year":"2021","journal-title":"Front. Allergy"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"609528","DOI":"10.3389\/fmed.2020.609528","article-title":"The Comorbid Relationship Between Migraine and Asthma: A Systematic Review and Meta-Analysis of Population-Based Studies","volume":"7","author":"Wang","year":"2020","journal-title":"Front. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1526-4610.1993.hed3308427.x","article-title":"The Prevalence of Headache and Migraine in Atopic Children: An Epidemiological Study in General Practice","volume":"33","author":"Mortimer","year":"1993","journal-title":"Headache"},{"key":"ref_65","first-page":"162","article-title":"Food Allergy Mediated by IgG Antibodies Associated with Migraine in Adults","volume":"54","year":"2007","journal-title":"Rev. Alerg. Mex."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1177\/0333102410361404","article-title":"Diet Restriction in Migraine, Based on IgG against Foods: A Clinical Double-Blind, Randomised, Cross-over Trial","volume":"30","author":"Alpay","year":"2010","journal-title":"Cephalalgia"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1177\/0333102410364856","article-title":"IgG-Mediated Allergy: A New Mechanism for Migraine Attacks?","volume":"30","author":"Pascual","year":"2010","journal-title":"Cephalalgia"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1468-2982.1994.1405365.x","article-title":"Immunocyte Enumeration in Duodenal Biopsies of Migraine without Aura Patients with or without Food-Induced Migraine","volume":"14","author":"Pradalier","year":"1994","journal-title":"Cephalalgia"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s10194-023-01547-8","article-title":"Genetics of Migraine: Where Are We Now?","volume":"24","author":"Grangeon","year":"2023","journal-title":"J. Headache Pain"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e13915","DOI":"10.1111\/pai.13915","article-title":"Environmental Influences on Childhood Asthma: Allergens","volume":"34","author":"Custovic","year":"2023","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1172\/JCI124612","article-title":"Environmental Exposures and Mechanisms in Allergy and Asthma Development","volume":"129","author":"Murrison","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"00528","DOI":"10.1183\/23120541.00528-2021","article-title":"Prevalence, Time Trends and Treatment Practices of Asthma in India: The Global Asthma Network Study","volume":"8","author":"Singh","year":"2022","journal-title":"ERJ Open. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4103\/0976-9668.127289","article-title":"Prevalence of Bronchial Asthma and Its Associated Factors among School Children in Urban Puducherry, India","volume":"5","author":"Kumar","year":"2014","journal-title":"J. Nat. Sc. Biol. Med."},{"key":"ref_74","first-page":"464","article-title":"Do Saharan Dust Days Carry a Risk of Hospitalization From Respiratory Diseases for Citizens of the Canary Islands (Spain)?","volume":"57","year":"2021","journal-title":"Arch. Bronconeumol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/j.1468-2982.2008.01839.x","article-title":"African Dust-Laden Atmospheric Conditions Activate the Trigeminovascular System","volume":"29","author":"Doganay","year":"2009","journal-title":"Cephalalgia"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1515\/med-2022-0598","article-title":"Migraine Management: Non-Pharmacological Points for Patients and Health Care Professionals","volume":"17","author":"Haghdoost","year":"2022","journal-title":"Open. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0030-6665(03)00181-6","article-title":"Sinus Headache: A Clinical Conundrum","volume":"37","author":"Cady","year":"2004","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4168\/aair.2018.10.3.187","article-title":"The Emerging Role of TRPV1 in Airway Inflammation","volume":"10","author":"Kim","year":"2018","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.molmed.2010.02.004","article-title":"TRPV1 in Migraine Pathophysiology","volume":"16","author":"Meents","year":"2010","journal-title":"Trends Mol. Med."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Sordyl, J., Kopyta, I., Sarecka-Hujar, B., Matusik, P., Francuz, T., and Malecka-Tendera, E. (2022). Selected Factors of Vascular Changes: The Potential Pathological Processes Underlying Primary Headaches in Children. Children, 9.","DOI":"10.3390\/children9111660"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2118740","DOI":"10.1155\/2022\/2118740","article-title":"Platelet P2Y12 Inhibitor in the Treatment and Prevention of Migraine: A Systematic Review and Meta-Analysis","volume":"2022","author":"Wang","year":"2022","journal-title":"Behav. Neurol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/MBC.0000000000000136","article-title":"Platelet Aggregation, Secretion, and Coagulation Changes in Children with Asthma","volume":"25","author":"Buyukyilmaz","year":"2014","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"663535","DOI":"10.3389\/fcell.2021.663535","article-title":"Neuroimmune Pathophysiology in Asthma","volume":"9","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1468-2982.2007.01497.x","article-title":"Vasoactive Intestinal Peptide Causes Marked Cephalic Vasodilation, but Does Not Induce Migraine","volume":"28","author":"Rahmann","year":"2008","journal-title":"Cephalalgia"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1526-4610.2010.01798.x","article-title":"Bronchial Hyper-Reactivity in Migraine without Aura: Is It a New Clue for Inflammation?","volume":"51","author":"Kaleagasi","year":"2011","journal-title":"Headache"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1129-2377-14-71","article-title":"TRPA1 and Other TRP Channels in Migraine","volume":"14","author":"Benemei","year":"2013","journal-title":"J. Headache Pain"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"113901","DOI":"10.1016\/j.bcp.2020.113901","article-title":"Exploring the Role of Nerves in Asthma; Insights from the Study of Cough","volume":"179","author":"Satia","year":"2020","journal-title":"Biochemical Pharmacology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1526-4610.2006.00294.x","article-title":"Salivary Levels of CGRP and VIP in Rhinosinusitis and Migraine Patients","volume":"46","author":"Bellamy","year":"2006","journal-title":"Headache"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nm.2755","article-title":"IgE and Mast Cells in Allergic Disease","volume":"18","author":"Galli","year":"2012","journal-title":"Nat. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.rmed.2016.05.026","article-title":"Can Bronchial Asthma with an Highly Prevalent Airway (and Systemic) Vagal Tone Be Considered an Independent Asthma Phenotype? Possible Role of Anticholinergics","volume":"117","author":"Liccardi","year":"2016","journal-title":"Respir. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fneur.2017.00163","article-title":"Cholinergic Nociceptive Mechanisms in Rat Meninges and Trigeminal Ganglia: Potential Implications for Migraine Pain","volume":"8","author":"Shelukhina","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","article-title":"Histamine in the Nervous System","volume":"88","author":"Haas","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0166-4328(01)00226-1","article-title":"Importance of Histamine in Modulatory Processes, Locomotion and Memory","volume":"124","author":"Philippu","year":"2001","journal-title":"Behav. Brain Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4419-8056-4_10","article-title":"Histamine in Neurotransmission and Brain Diseases","volume":"709","author":"Nuutinen","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1046\/j.1468-2982.1995.015002094.x","article-title":"The Nitric Oxide Hypothesis of Migraine and Other Vascular Headaches","volume":"15","author":"Olesen","year":"1995","journal-title":"Cephalalgia"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1124\/jpet.110.171264","article-title":"H3 Receptors and Pain Modulation: Peripheral, Spinal, and Brain Interactions","volume":"336","author":"Hough","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrd1631","article-title":"The Histamine H3 Receptor: From Gene Cloning to H3 Receptor Drugs","volume":"4","author":"Leurs","year":"2005","journal-title":"Nat. Rev. Drug. Discov."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0014-2999(03)01737-0","article-title":"Activation of Spinal Histamine H3 Receptors Inhibits Mechanical Nociception","volume":"470","author":"Cannon","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1468-2982.1997.1703166.x","article-title":"Release of Histamine from Dural Mast Cells by Substance P and Calcitonin Gene-Related Peptide","volume":"17","author":"Ottosson","year":"1997","journal-title":"Cephalalgia"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/head.13164","article-title":"Histamine and Migraine","volume":"58","author":"Yuan","year":"2018","journal-title":"Headache"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0887-8994(02)00466-6","article-title":"The Diet Factor in Pediatric and Adolescent Migraine","volume":"28","author":"Millichap","year":"2003","journal-title":"Pediatr. Neurol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/head.12365","article-title":"Wine and Headache","volume":"54","author":"Krymchantowski","year":"2014","journal-title":"Headache"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0304-3959(88)90012-7","article-title":"Headache Provocation by Continuous Intravenous Infusion of Histamine. Clinical Results and Receptor Mechanisms","volume":"8","author":"Krabbe","year":"1980","journal-title":"Pain"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2222.1982.tb01633.x","article-title":"Increased Plasma Histamine Levels in Migraine Patients","volume":"12","author":"Heatley","year":"1982","journal-title":"Clin. Allergy"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0006-8993(93)90465-Y","article-title":"Histamine Phase Shifts the Circadian Clock in a Manner Similar to Light","volume":"613","author":"Cote","year":"1993","journal-title":"Brain Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0165-6147(00)01504-2","article-title":"Is Histamine the Final Neurotransmitter in the Entrainment of Circadian Rhythms in Mammals?","volume":"21","author":"Jacobs","year":"2000","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuropharm.2015.04.011","article-title":"Histamine Receptor Signaling in Energy Homeostasis","volume":"106","author":"Tabarean","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00018-011-0631-8","article-title":"The Waking Brain: An Update","volume":"68","author":"Lin","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10072-019-03837-z","article-title":"Sleep Disorder-Related Headaches","volume":"40","author":"Galbiati","year":"2019","journal-title":"Neurol. Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/ana.21418","article-title":"Enhanced Circadian Phase Resetting in R192Q Cav2.1 Calcium Channel Migraine Mice","volume":"64","author":"Michel","year":"2008","journal-title":"Ann. Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/bph.14696","article-title":"Histamine, Histamine Receptors, and Neuropathic Pain Relief","volume":"177","author":"Obara","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.neuroscience.2013.06.014","article-title":"Hypothalamic and Basal Ganglia Projections to the Posterior Thalamus: Possible Role in Modulation of Migraine Headache and Photophobia","volume":"248","author":"Kagan","year":"2013","journal-title":"Neuroscience"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0014-2999(94)00668-W","article-title":"Regulation of Substance P Release Mediated via Prejunctional Histamine H3 Receptors","volume":"273","author":"Ohkubo","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/nrn3057","article-title":"Diencephalic and Brainstem Mechanisms in Migraine","volume":"12","author":"Akerman","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/0306-4522(83)90264-6","article-title":"Histamine and the Hypothalamus","volume":"9","author":"Roberts","year":"1983","journal-title":"Neuroscience"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s10194-021-01271-1","article-title":"Migraine and Neuroinflammation: The Inflammasome Perspective","volume":"22","author":"Kursun","year":"2021","journal-title":"J. Headache Pain"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/syn.10043","article-title":"Evidence for Activation of Histamine H3 Autoreceptors during Handling Stress in the Prefrontal Cortex of the Rat","volume":"43","author":"Westerink","year":"2002","journal-title":"Synapse"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/7854_2021_249","article-title":"Histamine as an Alert Signal in the Brain","volume":"59","author":"Mochizuki","year":"2022","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/ajcn\/85.5.1185","article-title":"Histamine and Histamine Intolerance","volume":"85","author":"Maintz","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1080\/10408398.2018.1450215","article-title":"Genetic Bases of the Nutritional Approach to Migraine","volume":"59","author":"Guadagni","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-Endothelial Interactions at the Blood-Brain Barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrn1034","article-title":"The Role of Histamine and the Tuberomamillary Nucleus in the Nervous System","volume":"4","author":"Haas","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jphs.2022.08.003","article-title":"Selective Histamine H2 Receptor Agonists Alleviate Blood-Brain Barrier Disruption by Promoting the Expression of Vascular Protective Factors Following Traumatic Brain Injury in Mice","volume":"150","author":"Michinaga","year":"2022","journal-title":"J. Pharmacol. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/bph.12257","article-title":"A Single-Point Mutation (Ala280Val) in the Third Intracellular Loop Alters the Signalling Properties of the Human Histamine H\u2083 Receptor Stably Expressed in CHO-K1 Cells","volume":"170","author":"Leurs","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.arcmed.2011.01.009","article-title":"A280V Polymorphism in the Histamine H3 Receptor as a Risk Factor for Migraine","volume":"42","year":"2011","journal-title":"Arch. Med. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1468-1331.2007.01744.x","article-title":"Subcutaneous Histamine versus Sodium Valproate in Migraine Prophylaxis: A Randomized, Controlled, Double-Blind Study","volume":"14","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"ref_127","first-page":"43","article-title":"Sch 50971, an Orally Active Histamine H3 Receptor Agonist, Inhibits Central Neurogenic Vascular Inflammation and Produces Sedation in the Guinea Pig","volume":"287","author":"McLeod","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2008.11.018","article-title":"Localization of Histamine H4 Receptors in the Central Nervous System of Human and Rat","volume":"1250","author":"Strakhova","year":"2009","journal-title":"Brain Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuropharm.2013.03.026","article-title":"Pleiotropic Effect of Histamine H4 Receptor Modulation in the Central Nervous System","volume":"71","author":"Galeotti","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1124\/mol.116.104752","article-title":"The Histamine H3 Receptor: Structure, Pharmacology, and Function","volume":"90","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00281-018-0676-y","article-title":"Neurogenic Inflammation and Its Role in Migraine","volume":"40","author":"Ramachandran","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/bph.12266","article-title":"The Role of Histamine in Neurogenic Inflammation","volume":"170","author":"Rosa","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pain.2007.03.012","article-title":"Mast Cell Degranulation Activates a Pain Pathway Underlying Migraine Headache","volume":"130","author":"Levy","year":"2007","journal-title":"Pain"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejphar.2018.12.004","article-title":"Progression in Migraine: Role of Mast Cells and pro-Inflammatory and Anti-Inflammatory Cytokines","volume":"844","author":"Conti","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1080\/14737175.2020.1797493","article-title":"An Update on Acute and Preventive Treatments for Migraine in Children and Adolescents","volume":"20","author":"Rao","year":"2020","journal-title":"Expert. Rev. Neurother."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ncl.2019.07.004","article-title":"Preventive Treatment for Episodic Migraine","volume":"37","author":"Parikh","year":"2019","journal-title":"Neurol. Clin."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3389\/fneur.2019.00771","article-title":"Prophylactic Treatment of Pediatric Migraine: Is There Anything New in the Last Decade?","volume":"10","author":"Papetti","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Papetti, L., Moavero, R., Ferilli, M.A.N., Sforza, G., Tarantino, S., Ursitti, F., Ruscitto, C., Vigevano, F., and Valeriani, M. (2021). Truths and Myths in Pediatric Migraine and Nutrition. Nutrients, 13.","DOI":"10.3390\/nu13082714"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1526-4610.2011.02070.x","article-title":"Rescue Therapy for Acute Migraine, Part 2: Neuroleptics, Antihistamines, and Others","volume":"52","author":"Kelley","year":"2012","journal-title":"Headache"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s10194-019-0984-1","article-title":"Histamine and Migraine Revisited: Mechanisms and Possible Drug Targets","volume":"20","author":"Worm","year":"2019","journal-title":"J. Headache Pain"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/jnnp.27.5.463","article-title":"CLINICAL TRIAL OF METHYSERGIDE AND OTHER PREPARATIONS IN THE MANAGEMENT OF MIGRAINE","volume":"27","author":"Curran","year":"1964","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0196-0644(87)80177-4","article-title":"The Effectiveness of Nalbuphine and Hydroxyzine for the Emergency Treatment of Severe Headache","volume":"16","author":"Tek","year":"1987","journal-title":"Ann. Emerg. Med."},{"key":"ref_143","first-page":"155","article-title":"Cinnarizine in Migraine Prophylaxis: Efficacy, Tolerability and Predictive Factors for Therapeutic Responsiveness. An Open-Label Pilot Trial","volume":"18","author":"Rossi","year":"2003","journal-title":"Funct. Neurol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3109\/00207454.2013.765419","article-title":"The Effects of Cinnarizine versus Sodium Valproate in Migraine Prophylaxis","volume":"123","author":"Bostani","year":"2013","journal-title":"Int. J. Neurosci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.pediatrneurol.2014.05.031","article-title":"Efficacy and Safety of Cinnarizine in the Prophylaxis of Migraine in Children: A Double-Blind Placebo-Controlled Randomized Trial","volume":"51","author":"Ashrafi","year":"2014","journal-title":"Pediatr. Neurol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1177\/0333102419888485","article-title":"Cinnarizine and Sodium Valproate as the Preventive Agents of Pediatric Migraine: A Randomized Double-Blind Placebo-Controlled Trial","volume":"40","author":"Amanat","year":"2020","journal-title":"Cephalalgia"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1177\/0333102418798611","article-title":"Effect of the H1-Antihistamine Clemastine on PACAP38 Induced Migraine","volume":"39","author":"Vollesen","year":"2019","journal-title":"Cephalalgia"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1526-4610.1978.hed1805261.x","article-title":"Controlled Trials of Cimetidine in Migraine and Cluster Headache","volume":"18","author":"Anthony","year":"1978","journal-title":"Headache"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1600-0404.1980.tb03008.x","article-title":"Cimetidine in the Prophylaxis of Migraine","volume":"62","author":"Nanda","year":"1980","journal-title":"Acta Neurol. Scand."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1046\/j.1526-4610.2003.03074.x","article-title":"Nalpha-Methylhistamine Safety and Efficacy in Migraine Prophylaxis: Phase I and Phase II Studies","volume":"43","author":"Tene","year":"2003","journal-title":"Headache"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000115637","article-title":"Subcutaneous Histamine versus Topiramate in Migraine Prophylaxis: A Double-Blind Study","volume":"59","author":"Baltazar","year":"2008","journal-title":"Eur. Neurol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1468-1331.2008.02352.x","article-title":"Subcutaneous Histamine versus Botulinum Toxin Type A in Migraine Prophylaxis: A Randomized, Double-Blind Study","volume":"16","year":"2009","journal-title":"Eur. J. Neurol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1017\/S0317167100016632","article-title":"N Alpha Methyl Histamine versus Propranolol in Migraine Prophylaxis","volume":"41","year":"2014","journal-title":"Can. J. Neurol. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pbb.2009.12.004","article-title":"H4 Receptor Antagonism Exhibits Anti-Nociceptive Effects in Inflammatory and Neuropathic Pain Models in Rats","volume":"95","author":"Hsieh","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejphar.2007.02.026","article-title":"Antiinflammatory and Antinociceptive Effects of the Selective Histamine H4-Receptor Antagonists JNJ7777120 and VUF6002 in a Rat Model of Carrageenan-Induced Acute Inflammation","volume":"563","author":"Coruzzi","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S0317167100004960","article-title":"Nalpha-Methyl Histamine Safety and Efficacy in Migraine Prophylaxis: Phase III Study","volume":"33","author":"Tene","year":"2006","journal-title":"Can. J. Neurol. Sci."},{"key":"ref_157","first-page":"223","article-title":"A Double Blind Controlled Study of Propranolol and Cyproheptadine in Migraine Prophylaxis","volume":"48","author":"Rao","year":"2000","journal-title":"Neurol. India"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/bs.podrm.2017.02.006","article-title":"Propranolol","volume":"42","author":"Bakheit","year":"2017","journal-title":"Profiles Drug. Subst. Excip. Relat. Methodol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"104587","DOI":"10.1016\/j.phrs.2019.104587","article-title":"\u03b2-Blockers: Their New Life from Hypertension to Cancer and Migraine","volume":"151","author":"Fumagalli","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_160","first-page":"973","article-title":"Preventive Migraine Treatment","volume":"21","author":"Silberstein","year":"2015","journal-title":"Continuum"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2165\/00003495-198427010-00002","article-title":"Flunarizine. A Review of Its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Use","volume":"27","author":"Holmes","year":"1984","journal-title":"Drugs"},{"key":"ref_162","first-page":"42","article-title":"Cerebral Antivasoconstrictive Effects of Flunarizine","volume":"460","author":"Janssens","year":"1988","journal-title":"Acta Otolaryngol. Suppl."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/j.pain.0000000000001456","article-title":"Flunarizine as Prophylaxis for Episodic Migraine: A Systematic Review with Meta-Analysis","volume":"160","author":"Stubberud","year":"2019","journal-title":"Pain"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fneur.2017.00524","article-title":"The Efficacy of Venlafaxine, Flunarizine, and Valproic Acid in the Prophylaxis of Vestibular Migraine","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1468-2982.1998.1807421.x","article-title":"Methysergide","volume":"18","author":"Silberstein","year":"1998","journal-title":"Cephalalgia"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.amjmed.2005.09.045","article-title":"Centrally Active Nonhormonal Hot Flash Therapies","volume":"118","author":"Loprinzi","year":"2005","journal-title":"Am. J. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1080\/14737175.2020.1787834","article-title":"Cinnarizine as an Alternative Recommendation for Migraine Prophylaxis: A Narrative Review","volume":"20","author":"Togha","year":"2020","journal-title":"Expert Rev. Neurother."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/papr.13164","article-title":"Application of Cinnarizine in Migraine Prevention: A Systematic Review and Meta-Analysis","volume":"22","author":"Kouhanjani","year":"2022","journal-title":"Pain Pract."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"516","DOI":"10.2174\/1871527318666190703094846","article-title":"Central Histamine, the H3-Receptor and Obesity Therapy","volume":"18","year":"2019","journal-title":"CNS Neurol. Disord. Drug. Targets"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acschemneuro.1c00435","article-title":"Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties","volume":"13","author":"Podlewska","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"ref_171","first-page":"610","article-title":"Identification of Two H3-Histamine Receptor Subtypes","volume":"38","author":"West","year":"1990","journal-title":"Mol. Pharmacol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0306-4522(87)90279-X","article-title":"Autoinhibition of Histamine Synthesis Mediated by Presynaptic H3-Receptors","volume":"23","author":"Arrang","year":"1987","journal-title":"Neuroscience"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s10194-023-01573-6","article-title":"European Headache Federation (EHF) Critical Re-Appraisal and Meta-Analysis of Oral Drugs in Migraine Prevention-Part 1: Amitriptyline","volume":"24","author":"Lampl","year":"2023","journal-title":"J. Headache Pain"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1476-5381.2009.00227.x","article-title":"The Histamine H4 Receptor Is Functionally Expressed on Neurons in the Mammalian CNS","volume":"157","author":"Connelly","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"110296","DOI":"10.1016\/j.envres.2020.110296","article-title":"The Effect of Acute Outdoor Air Pollution on Peak Expiratory Flow in Individuals with Asthma: A Systematic Review and Meta-Analysis","volume":"192","author":"Edginton","year":"2021","journal-title":"Environ. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.envint.2018.09.022","article-title":"Ambient Air Pollution Exposure and Risk of Migraine: Synergistic Effect with High Temperature","volume":"121","author":"Lee","year":"2018","journal-title":"Environ. 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