{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:09:57Z","timestamp":1760148597242,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"The Research Council of Norway","doi-asserted-by":"publisher","award":["288022","NNF18OC0034130"],"award-info":[{"award-number":["288022","NNF18OC0034130"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["288022","NNF18OC0034130"],"award-info":[{"award-number":["288022","NNF18OC0034130"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Internal Medicine Association of Norway","award":["288022","NNF18OC0034130"],"award-info":[{"award-number":["288022","NNF18OC0034130"]}]},{"name":"regional agreement on medical training and clinical research in Stockholm","award":["288022","NNF18OC0034130"],"award-info":[{"award-number":["288022","NNF18OC0034130"]}]},{"name":"legate of Dr. Nils Henrichsen and his Wife Anna Henrichsen","award":["288022","NNF18OC0034130"],"award-info":[{"award-number":["288022","NNF18OC0034130"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: Residual adrenocortical function, RAF, has recently been demonstrated in one-third of patients with autoimmune Addison\u2019s disease (AAD). Here, we set out to explore any influence of RAF on the levels of plasma metanephrines and any changes following stimulation with cosyntropin. Methods: We included 50 patients with verified RAF and 20 patients without RAF who served as controls upon cosyntropin stimulation testing. The patients had abstained from glucocorticoid and fludrocortisone replacement &gt; 18 and 24 h, respectively, prior to morning blood sampling. The samples were obtained before and 30 and 60 min after cosyntropin stimulation and analyzed for serum cortisol, plasma metanephrine (MN), and normetanephrine (NMN) by liquid-chromatography tandem-mass pectrometry (LC-MS\/MS). Results: Among the 70 patients with AAD, MN was detectable in 33%, 25%, and 26% at baseline, 30 min, and 60 min after cosyntropin stimulation, respectively. Patients with RAF were more likely to have detectable MN at baseline (p = 0.035) and at the time of 60 min (p = 0.048) compared to patients without RAF. There was a positive correlation between detectable MN and the level of cortisol at all time points (p = 0.02, p = 0.04, p &lt; 0.001). No difference was noted for NMN levels, which remained within the normal reference ranges. Conclusion: Even very small amounts of endogenous cortisol production affect MN levels in patients with AAD.<\/jats:p>","DOI":"10.3390\/jcm12103602","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T02:02:27Z","timestamp":1684807347000},"page":"3602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma-Metanephrines in Patients with Autoimmune Addison\u2019s Disease with and without Residual Adrenocortical Function"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-7695","authenticated-orcid":false,"given":"Anna-Karin","family":"\u00c5kerman","sequence":"first","affiliation":[{"name":"Department of Medicine, \u00d6rebro University Hospital, 701 85 \u00d6rebro, Sweden"},{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5se Bjorvatn","family":"S\u00e6vik","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-1035","authenticated-orcid":false,"given":"Per Medb\u00f8e","family":"Thorsby","sequence":"additional","affiliation":[{"name":"Hormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, 0372 Oslo, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, 0372 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paal","family":"Methlie","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway"},{"name":"Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Quinkler","sequence":"additional","affiliation":[{"name":"Endocrinology in Charlottenburg, 10627 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1246-9194","authenticated-orcid":false,"given":"Anders Palmstr\u00f8m","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Oslo University Hospital, 0372 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"H\u00f6ybye","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden"},{"name":"Department of Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra J.","family":"Debowska","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vestfold Hospital Trust, 3103 T\u00f8nsberg, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1635-8325","authenticated-orcid":false,"given":"Bj\u00f8rn Gunnar","family":"Nedreb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"Department of Internal Medicine, Haugesund Hospital, 5528 Haugesund, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Lise","family":"Dahle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Haugesund Hospital, 5528 Haugesund, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siri","family":"Carlsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Stavanger University Hospital, 4068 Stavanger, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneta","family":"Tomkowicz","sequence":"additional","affiliation":[{"name":"Department of Medicine, S\u00f8rlandet Hospital, 4604 Kristiansand, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stina Therese","family":"Sollid","sequence":"additional","affiliation":[{"name":"Department of Medicine, Drammen Hospital, Vestre Viken Health Trust, 3004 Drammen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Nermoen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Akershus University Hospital, 1478 L\u00f8renskog, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaja","family":"Gr\u00f8nning","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Akershus University Hospital, 1478 L\u00f8renskog, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6471-9503","authenticated-orcid":false,"given":"Per","family":"Dahlqvist","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Ume\u00e5 University, 901 87 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guri","family":"Grimnes","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, University Hospital of North Norway, 9038 Troms\u00f8, Norway"},{"name":"Troms\u00f8 Endocrine Research Group, Department of Clinical Medicine, UiT the Arctic University of Norway, 9037 Troms\u00f8, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3738-1367","authenticated-orcid":false,"given":"Jakob","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-8706","authenticated-orcid":false,"given":"Trine","family":"Finnes","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Innlandet Hospital Trust, 2381 Hamar, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Wahlberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, \u00d6rebro University Hospital, 701 85 \u00d6rebro, Sweden"},{"name":"School of Medical Sciences, Faculty of Medicine and Health, \u00d6rebro University, 702 81 \u00d6rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9090-8815","authenticated-orcid":false,"given":"Synn\u00f8ve Emblem","family":"Holte","sequence":"additional","affiliation":[{"name":"Department of Medicine, S\u00f8rlandet Hospital, 4838 Arendal, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Simunkova","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olle","family":"K\u00e4mpe","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden"},{"name":"Department of Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden"},{"name":"Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eystein Sverre","family":"Husebye","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway"},{"name":"Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway"},{"name":"Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"\u00d8ksnes","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway"},{"name":"Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway"},{"name":"Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Bensing","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden"},{"name":"Department of Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"ref_1","unstructured":"Feingold, K.R. (2017). 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