{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:48:12Z","timestamp":1773967692654,"version":"3.50.1"},"reference-count":54,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The study aims to evaluate and compare the onset of local anesthesia (LA) and pain perception during endodontic treatment in hemophilic and thalassemic patients. Methods: The study included 90 patients with symptomatic irreversible pulpitis of the mandibular molars. Three groups (n = 30 in each group) were included. Group 1: hemophilic patients; group 2: thalassemic patients; and group 3: individuals without any systemic diseases. Onset of LA and visual analogue scale (VAS) scores was recorded immediately after the administration of local anesthesia, during the pulp exposure procedure, and during canal instrumentation, and were compared between the three groups. Frequency distribution, ANOVA, and linear regression analysis (p &lt; 0.05) were applied. Results: The mean onset time was 46 \u00b1 34 s in the hemophilic group, 42 \u00b1 23 s in the thalassemic group, and 38 \u00b1 12 s in controls, but the differences were statistically insignificant. After LA administration (LA-VAS), all three groups experienced a statistically significant reduction in pain (p = 0.048). On pulp exposure (PE-VAS) (p = 0.82) and during canal instrumentation (CI-VAS) (p = 0.55), there was no statistically significant difference in pain perception between the groups. The coefficients indicate a positive correlation between the VAS and onset time, indicating a positive reduction in the VAS following the administration of LA. Conclusions: Hemophilic patients exhibited a clinically longer average onset time for LA. However, the difference among the three groups with regard to the overall pain perception after LA administration, during and after pulp exposure, and during canal instrumentation was statistically insignificant.<\/jats:p>","DOI":"10.3390\/jcm12113646","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T02:00:55Z","timestamp":1684980055000},"page":"3646","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Local Anesthesia Onset and Pain Perception in Hemophilic and Thalassemic Conditions"],"prefix":"10.3390","volume":"12","author":[{"given":"Supriya","family":"Das","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to Be) University, Bhubaneswar 751003, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-3087","authenticated-orcid":false,"given":"Shashirekha","family":"Govind","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to Be) University, Bhubaneswar 751003, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debkant","family":"Jena","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to Be) University, Bhubaneswar 751003, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit","family":"Dash","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to Be) University, Bhubaneswar 751003, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siba Prasad","family":"Jena","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to Be) University, Bhubaneswar 751003, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to Be) University, Bhubaneswar 751003, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita","family":"Karan","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Shadan Institute of Medical Sciences Research Centre and Teaching Hospital, Himayat Sagar, Hyderabad 500086, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyothsna","family":"Kancherla","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Dr.V.R.K. Women\u2019s Medical College Teaching Hospital and Research Centre, Aziz nagar, Hyderabad 500075, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Jena","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Sriram Chandra Bhanja Dental College & Hospital, Cuttack 753007, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8680-2172","authenticated-orcid":false,"given":"Lora","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to Be) University, Bhubaneswar 751003, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sourav Chandra Bidyasagar","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to Be) University, Bhubaneswar 751003, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satabdi","family":"Pattanaik","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to Be) University, Bhubaneswar 751003, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.4103\/2231-0762.149022","article-title":"Hemophilia A: Dental Considerations and Management","volume":"4","author":"Shastry","year":"2014","journal-title":"J. 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