{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:09:28Z","timestamp":1788797368149,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Oral rehabilitation after maxillary oncological resection is challenging. This case report presents the rehabilitation of a 65-year-old Caucasian male adenoid cystic carcinoma patient using a myo-cutaneous thigh flap, zygomatic implant placement, and an immediate fixed provisional prosthesis made with computer-aided technologies. The patient presented complaints of asymptomatic enlarged swelling of 5-mm on the right hard hemi-palate. There was an oro-antral communication deriving from a previous local excision. Preoperative radiographs showed the involvement of the right maxilla, maxillary sinus, and nose with a suspect involvement of the maxillary division of the trigeminal nerve. Treatment was planned through a fully digital workflow. A partial maxillectomy was performed endoscopically, and maxilla was reconstructed using an anterolateral thigh free flap. Two zygomatic implants were inserted simultaneously. A provisional fix full-arch prosthesis was manufactured preoperatively through a fully digital workflow and was placed in the operating room. Following post-operative radiotherapy, the patient received a final hybrid prosthesis. During the follow-up period of two years, the patient reported good function, aesthetics, and significant enhancement in quality of life. According to the results of this case, the protocol represented can be a promising alternative for oral cancer patients with large defects, and can lead to an improved quality of life.<\/jats:p>","DOI":"10.3390\/jcm12113653","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T02:00:55Z","timestamp":1684980055000},"page":"3653","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Guided Zygomatic Implantology for Oral Cancer Rehabilitation: A Case Report"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3770-1375","authenticated-orcid":false,"given":"Francesco","family":"Grecchi","sequence":"first","affiliation":[{"name":"Private Practice, Via Boccaccio 34, 20123 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-2456","authenticated-orcid":false,"given":"Roberto Giuseppe","family":"D\u2019Ambrogio","sequence":"additional","affiliation":[{"name":"Department of Surgical Specialties, Dental Clinic, School of Dentistry, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Vito","family":"Stefanelli","sequence":"additional","affiliation":[{"name":"Private Practice, Viale Leonardo Da Vinci 256, 00145 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Grivetto","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria Maggiore Della Carit\u00e0 Largo Bellini, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2354-361X","authenticated-orcid":false,"given":"Funda","family":"Goker","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, University of Milano, 20122 Milan, Italy"},{"name":"Dental and Maxillo-Facial Surgery Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-0984","authenticated-orcid":false,"given":"Massimo","family":"Del Fabbro","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, University of Milano, 20122 Milan, Italy"},{"name":"Dental and Maxillo-Facial Surgery Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Surgical Specialties, Ear, Nose and Throat Clinic, School of Dentistry, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Piazza","sequence":"additional","affiliation":[{"name":"Department of Surgical Specialties, Ear, Nose and Throat Clinic, School of Dentistry, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6558-9141","authenticated-orcid":false,"given":"Stefano","family":"Salgarello","sequence":"additional","affiliation":[{"name":"Department of Surgical Specialties, Dental Clinic, School of Dentistry, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Dosio","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria Maggiore Della Carit\u00e0 Largo Bellini, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3417-5488","authenticated-orcid":false,"given":"Emma","family":"Grecchi","sequence":"additional","affiliation":[{"name":"Private Practice, Via Boccaccio 34, 20123 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s10147-005-0504-y","article-title":"Choice of osseous and osteocutaneous flaps for mandibular reconstruction","volume":"10","author":"Takushima","year":"2005","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_2","first-page":"7","article-title":"Mandible Reconstruction: A Review Article","volume":"1","author":"Baccarani","year":"2015","journal-title":"J. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00405-016-4266-0","article-title":"Palato-maxillary reconstruction by the angular branch-based tip of scapula free flap","volume":"274","author":"Piazza","year":"2017","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1067\/mpr.2001.119524","article-title":"Prosthodontic guidelines for surgical reconstruction of the maxilla: A classification system of defects","volume":"86","author":"Okay","year":"2001","journal-title":"J. Prosthet. Dent."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S1470-2045(10)70113-3","article-title":"Reconstruction of the maxilla and midface: Introducing a new classification","volume":"11","author":"Brown","year":"2010","journal-title":"Lancet Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jcms.2012.05.004","article-title":"Definition of quality indicators in microsurgery in head and neck reconstruction based on a 5-year follow-up without a loss","volume":"41","author":"Kessler","year":"2013","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jcms.2012.07.006","article-title":"Rehabilitation with endosseous implants in fibula free-flap mandibular reconstruction: A case series of up to 10 years","volume":"41","author":"Ferrari","year":"2013","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.joms.2012.07.002","article-title":"Microsurgical free flap reconstructions of head and neck region in 406 cases: A 13-year experience","volume":"71","author":"Gerressen","year":"2013","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/cid.12658","article-title":"Long-term results of osseointegrated implant-based dental rehabilitation in oncology patients reconstructed with a fibula free flap","volume":"20","author":"Pellegrino","year":"2018","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/lary.28064","article-title":"The Alberta Reconstructive Technique: An Occlusion-Driven and Digitally Based Jaw Reconstruction","volume":"129","author":"Seikaly","year":"2019","journal-title":"Laryngoscope"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jcms.2021.03.002","article-title":"Long-term outcomes of implant-based dental rehabilitation in head and neck cancer patients after reconstruction with the free vascularized fibula flap","volume":"49","author":"Lodders","year":"2021","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1007\/s00405-022-07277-y","article-title":"Changing trends in the microvascular reconstruction and oral rehabilitation following maxillary cancer","volume":"279","author":"Rogers","year":"2022","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_13","first-page":"871","article-title":"Single-tooth rehabilitation using osseointegration. A modified surgical and prosthodontic approach","volume":"19","author":"Ohrnell","year":"1988","journal-title":"Quintessence Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cden.2020.09.015","article-title":"Zygomatic Implants: A Solution for the Atrophic Maxilla: 2021 Update","volume":"65","author":"Rosenstein","year":"2021","journal-title":"Dent. Clin. N. Am."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Varghese, K.G., Gandhi, N., Kurian, N., Daniel, A.Y., Dhawan, K., Joseph, M., and Varghese, M.G. (2021). Rehabilitation of the severely resorbed maxilla by using quad zygomatic implant-supported prostheses: A systematic review and meta-analysis. J. Prosthet. Dent., in press.","DOI":"10.1016\/j.prosdent.2021.11.007"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cxom.2021.04.001","article-title":"Zygomatic Implants: A Review of a Treatment Alternative for the Severely Atrophic Maxilla","volume":"29","author":"Andre","year":"2021","journal-title":"Atlas. Oral Maxillofac. Surg. Clin. N. Am."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Di Cosola, M., Ballini, A., Zhurakivska, K., Ceccarello, A., Nocini, R., Malcangi, A., Mori, G., Lo Muzio, L., Cantore, S., and Olivo, A. (2021). Retrospective Analysis of Clinical and Radiologic Data Regarding Zygomatic Implant Rehabilitation with a Long-Term Follow-Up. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182412963"},{"key":"ref_18","first-page":"521","article-title":"A protocol for maxillary reconstruction following oncology resection using zygomatic implants","volume":"20","author":"Howes","year":"2007","journal-title":"Int. J. Prosthodont."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/odi.13305","article-title":"Zygomatic implant-based rehabilitation for patients with maxillary and mid-facial oncology defects: A review","volume":"27","author":"Hackett","year":"2021","journal-title":"Oral Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e541","DOI":"10.4317\/medoral.23569","article-title":"Quality assessment of systematic reviews regarding the effectiveness of zygomatic implants: An overview of systematic reviews","volume":"25","author":"Sales","year":"2020","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40729-017-0100-8","article-title":"The zygomatic implant perforated (ZIP) flap: A new technique for combined surgical reconstruction and rapid fixed dental rehabilitation following low-level maxillectomy","volume":"3","author":"Butterworth","year":"2017","journal-title":"Int. J. Implant. Dent."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40902-017-0112-6","article-title":"Maxillary resection for cancer, zygomatic implants insertion, and palatal repair as single-stage procedure: Report of three cases","volume":"39","author":"Salvatori","year":"2017","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/hed.25645","article-title":"Primary vs secondary zygomatic implant placement in patients with head and neck cancer-A 10-year prospective study","volume":"41","author":"Butterworth","year":"2019","journal-title":"Head Neck"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/hed.26933","article-title":"The Zygomatic Implant Perforated (ZIP) flap reconstructive technique for the management of low-level maxillary malignancy\u2014Clinical & patient related outcomes on 35 consecutively treated patients","volume":"44","author":"Butterworth","year":"2022","journal-title":"Head Neck"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"103942","DOI":"10.1016\/j.jdent.2021.103942","article-title":"A novel guided zygomatic implant surgery system compared to free hand: A human cadaver study on accuracy","volume":"119","author":"Grecchi","year":"2022","journal-title":"J. Dent."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Grecchi, F., Stefanelli, L.V., Grivetto, F., Grecchi, E., Siev, R., Mazor, Z., Del Fabbro, M., Pranno, N., Franchina, A., and Di Lucia, V. (2021). A Novel Guided Zygomatic and Pterygoid Implant Surgery System: A Human Cadaver Study on Accuracy. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18116142"},{"key":"ref_27","first-page":"20","article-title":"Zygoma implants for midfacial prosthetic rehabilitation using telescopes: 9-year follow-up","volume":"22","author":"Landes","year":"2009","journal-title":"Int. J. Prosthodont."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.joms.2006.05.067","article-title":"Stereomodel-assisted fibula flap harvest and mandibular reconstruction","volume":"65","author":"Yeung","year":"2007","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/cid.12928","article-title":"Dental implant-based oral rehabilitation in patients reconstructed with free fibula flaps: Clinical study with a follow-up 3 to 6\u2009years","volume":"22","author":"Goker","year":"2020","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/micr.30505","article-title":"A multicenter survey on computer-aided design and computer-aided manufacturing mandibular reconstruction from Italian community","volume":"39","author":"Ferri","year":"2019","journal-title":"Microsurgery"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/clr.13346","article-title":"The accuracy of static computer-aided implant surgery: A systematic review and meta-analysis","volume":"29","author":"Tahmaseb","year":"2018","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/prd.12046","article-title":"Guided surgery: Accuracy and efficacy","volume":"66","author":"Vercruyssen","year":"2014","journal-title":"Periodontology 2000"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.prosdent.2015.10.017","article-title":"Photogrammetric method to measure the discrepancy between clinical and software-designed positions of implants","volume":"115","author":"Rivara","year":"2016","journal-title":"J. Prosthet. Dent."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/j.jcms.2016.08.024","article-title":"Accuracy of virtually 3D planned resection templates in mandibular reconstruction","volume":"44","author":"Weijs","year":"2016","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2446.e1","DOI":"10.1016\/j.joms.2015.08.020","article-title":"Computer-Aided Rehabilitation of Maxillary Oncological Defects Using Zygomatic Implants: A Defect-Based Classification","volume":"73","author":"Pellegrino","year":"2015","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_36","first-page":"1694063","article-title":"Oral Rehabilitation of Oral Cancer Patients Using Zygomatic Implant-Supported Maxillary Prostheses with Magnetic Attachment: Three Case Reports","volume":"2018","author":"Ozaki","year":"2018","journal-title":"Case Rep. Dent."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/hed.25134","article-title":"Comprehensive approach to functional palatomaxillary reconstruction using regional and free tissue transfer: Report of reconstructive and prosthodontic outcomes of 140 patients","volume":"40","author":"Urken","year":"2018","journal-title":"Head Neck"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00020840-200308000-00001","article-title":"Hard and soft palate reconstruction","volume":"11","year":"2003","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.fsc.2009.01.008","article-title":"Reconstruction of the midface and maxilla","volume":"17","author":"Shrime","year":"2009","journal-title":"Facial Plast. Surg. Clin. N. Am."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.joms.2004.06.027","article-title":"Reconstruction of extensive maxillary defects using zygomaticus implants","volume":"62","author":"Schmidt","year":"2004","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s41415-022-4342-3","article-title":"Pathways for the rehabilitation of resection defects in the maxilla","volume":"232","author":"Barraclough","year":"2022","journal-title":"Br. Dent. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1600-0501.2004.01076.x","article-title":"Oral rehabilitation after mandibular reconstruction using an osteocutaneous fibula free flap with endosseous implants: Factors affecting the functional outcome in patients with oral cancer","volume":"16","author":"Iizuka","year":"2005","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.oraloncology.2007.07.005","article-title":"Fibula free flap reconstruction of the mandible in cancer patients: Evaluation of a combined surgical and prosthodontic treatment concept","volume":"44","author":"Smolka","year":"2008","journal-title":"Oral Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1600-0501.2005.01212.x","article-title":"Clinical outcome of dental implants placed in fibula-free flaps used for the reconstruction of maxillo-mandibular defects following ablation for tumors or osteoradionecrosis","volume":"17","author":"Chiapasco","year":"2006","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.prosdent.2006.05.010","article-title":"Efficacy of conventional and implant-supported mandibular resection prostheses: Study overview and treatment outcomes","volume":"96","author":"Garrett","year":"2006","journal-title":"J. Prosthet. Dent."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.ijom.2010.06.011","article-title":"Biomechanical three-dimensional finite-element analysis of maxillary prostheses with implants. Design of number and position of implants for maxillary prostheses after hemimaxillectomy","volume":"39","author":"Miyamoto","year":"2010","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Vosselman, N., Glas, H.H., Merema, B.J., Kraeima, J., Reintsema, H., Raghoebar, G.M., Witjes, M., and de Visscher, S. (2022). Three-Dimensional Guided Zygomatic Implant Placement after Maxillectomy. J. Pers. Med., 12.","DOI":"10.3390\/jpm12040588"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.11607\/jomi.2304","article-title":"Finite element analysis of zygomatic implants in intrasinus and extramaxillary approaches for prosthetic rehabilitation in severely atrophic maxillae","volume":"28","author":"Ishak","year":"2013","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijom.2010.09.019","article-title":"Evaluation of the quality of life of patients with maxillofacial defects after prosthodontic therapy with obturator prostheses","volume":"40","author":"Depprich","year":"2011","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_50","unstructured":"Beumer, J., Marunick, M.T., and Esposito, S.C. (2011). Maxillofacial Rehabilitation: Prosthodontic and Surgical Management of Cancer-Related, Acquired, and Congenital Defects of the Head and Neck, Quintessence Publishing. [3rd ed.]."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bjps.2008.06.084","article-title":"Patient satisfaction with maxillofacial prosthesis. Literature review","volume":"62","author":"Goiato","year":"2009","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13005-017-0160-2","article-title":"Quality of life and problems associated with obturators of patients with maxillectomies","volume":"14","author":"Ali","year":"2018","journal-title":"Head Face Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/clr.13577","article-title":"Masticatory performance and oral health-related quality of life in edentulous maxillectomy patients: A cross-sectional study to compare implant-supported obturators and conventional obturators","volume":"31","author":"Buurman","year":"2020","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/clr.12771","article-title":"Functional outcome and quality of life after a maxillectomy: A comparison between an implant supported obturator and implant supported fixed prostheses in a free vascularized flap","volume":"28","author":"Wang","year":"2017","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_55","first-page":"243","article-title":"Complex craniofacial reconstruction using an implant-supported prosthesis: Case report with long-term follow-up","volume":"12","author":"Tolman","year":"1997","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/02844310310023918","article-title":"Zygoma fixture in the management of advanced atrophy of the maxilla: Technique and long-term results","volume":"38","author":"Ohrnell","year":"2004","journal-title":"Scand J. Plast. Reconstr. Surg. Hand Surg."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"293","DOI":"10.11607\/jomi.3691","article-title":"Reliability of four zygomatic implant-supported prostheses for the rehabilitation of the atrophic maxilla: A systematic review","volume":"30","author":"Wang","year":"2015","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_58","first-page":"79","article-title":"Immediate loading of zygomatic implants: A systematic review of implant survival, prosthesis survival and potential complications","volume":"10","author":"Tuminelli","year":"2017","journal-title":"Eur. J. Oral Implantol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jcms.2023.01.008","article-title":"Analysis of intraoral microvascular anastomosis in maxillofacial defects reconstruction","volume":"51","author":"Zhang","year":"2023","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"916967","DOI":"10.3389\/fbioe.2022.916967","article-title":"Customized Barrier Membrane (Titanium Alloy, Poly Ether-Ether Ketone and Unsintered Hydroxyapatite\/Poly-l-Lactide) for Guided Bone Regeneration","volume":"28","author":"Shi","year":"2022","journal-title":"Front. Bioeng. Biotechnol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/11\/3653\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:41:25Z","timestamp":1760125285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/11\/3653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":60,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["jcm12113653"],"URL":"https:\/\/doi.org\/10.3390\/jcm12113653","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,24]]}}}