{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:37Z","timestamp":1787028637410,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Righospitalets Forskningsfond","award":["07IO"],"award-info":[{"award-number":["07IO"]}]},{"name":"Righospitalets Forskningsfond","award":["13-A750"],"award-info":[{"award-number":["13-A750"]}]},{"name":"Righospitalets Forskningsfond","award":["25-A1365"],"award-info":[{"award-number":["25-A1365"]}]},{"name":"Righospitalets Forskningsfond","award":["A6024"],"award-info":[{"award-number":["A6024"]}]},{"name":"Righospitalets Forskningsfond","award":["R186-2015-2132"],"award-info":[{"award-number":["R186-2015-2132"]}]},{"name":"Forskningspuljen ml RH og OUH","award":["07IO"],"award-info":[{"award-number":["07IO"]}]},{"name":"Forskningspuljen ml RH og OUH","award":["13-A750"],"award-info":[{"award-number":["13-A750"]}]},{"name":"Forskningspuljen ml RH og OUH","award":["25-A1365"],"award-info":[{"award-number":["25-A1365"]}]},{"name":"Forskningspuljen ml RH og OUH","award":["A6024"],"award-info":[{"award-number":["A6024"]}]},{"name":"Forskningspuljen ml RH og OUH","award":["R186-2015-2132"],"award-info":[{"award-number":["R186-2015-2132"]}]},{"name":"Danish Heart Foundation","award":["07IO"],"award-info":[{"award-number":["07IO"]}]},{"name":"Danish Heart Foundation","award":["13-A750"],"award-info":[{"award-number":["13-A750"]}]},{"name":"Danish Heart Foundation","award":["25-A1365"],"award-info":[{"award-number":["25-A1365"]}]},{"name":"Danish Heart Foundation","award":["A6024"],"award-info":[{"award-number":["A6024"]}]},{"name":"Danish Heart Foundation","award":["R186-2015-2132"],"award-info":[{"award-number":["R186-2015-2132"]}]},{"name":"Lundbeck Foundation","award":["07IO"],"award-info":[{"award-number":["07IO"]}]},{"name":"Lundbeck Foundation","award":["13-A750"],"award-info":[{"award-number":["13-A750"]}]},{"name":"Lundbeck Foundation","award":["25-A1365"],"award-info":[{"award-number":["25-A1365"]}]},{"name":"Lundbeck Foundation","award":["A6024"],"award-info":[{"award-number":["A6024"]}]},{"name":"Lundbeck Foundation","award":["R186-2015-2132"],"award-info":[{"award-number":["R186-2015-2132"]}]},{"name":"Hjertecentrets Forskningsudvalg, Rigshospitalet","award":["07IO"],"award-info":[{"award-number":["07IO"]}]},{"name":"Hjertecentrets Forskningsudvalg, Rigshospitalet","award":["13-A750"],"award-info":[{"award-number":["13-A750"]}]},{"name":"Hjertecentrets Forskningsudvalg, Rigshospitalet","award":["25-A1365"],"award-info":[{"award-number":["25-A1365"]}]},{"name":"Hjertecentrets Forskningsudvalg, Rigshospitalet","award":["A6024"],"award-info":[{"award-number":["A6024"]}]},{"name":"Hjertecentrets Forskningsudvalg, Rigshospitalet","award":["R186-2015-2132"],"award-info":[{"award-number":["R186-2015-2132"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Neutrophil gelatinase-associated lipocalin (NGAL) is an inflammatory biomarker related to acute kidney injury (AKI). Including 1892 consecutive patients with ST-elevation myocardial infarction (STEMI), in which NGAL was measured in 1624 (86%) on admission and in a consecutive subgroup at 6\u201312 h (n = 163) and 12\u201324 h (n = 222) after admission, this study aimed to evaluate the prognostic value of NGAL in predicting AKI and mortality. Patients were stratified based on whether their admission NGAL plasma concentration was greater than or equal to\/less than the median. The primary endpoint was a composite of the first occurrence of AKI or all-cause death within 30 days. AKI was classified by the maximal plasma creatinine increase from baseline during index admission as KDIGO1 (&lt;200% increase) or KDIGO23 (\u2265200% increase) according to the Kidney Disease Improving Global Outcomes (KDIGO) system. Admission NGAL &gt; the median was independently associated with a higher risk of severe AKI (KDIGO2-3) and 30-day all-cause mortality when adjusted for age, admission systolic blood pressure and high-sensitivity C-reactive protein, left-ventricular ejection fraction, known kidney dysfunction, and cardiogenic shock with an odds ratio (95% confidence interval) of 2.26 (1.18\u20134.51), p = 0.014. Finally, we observed increasing predictive values in a subgroup during the first day of hospitalization suggesting that assessment of NGAL should be delayed for optimal prognostic purposes.<\/jats:p>","DOI":"10.3390\/jcm12113681","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T02:05:44Z","timestamp":1685066744000},"page":"3681","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with ST-Elevation Myocardial Infarction and Its Association with Acute Kidney Injury and Mortality"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7463-248X","authenticated-orcid":false,"given":"Mathias Alexander","family":"H\u00f8jagergaard","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5880-3733","authenticated-orcid":false,"given":"Rasmus Paulin","family":"Beske","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1199-0981","authenticated-orcid":false,"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Holmvang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette Okkels","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacov","family":"Shacham","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Abild Stengaard","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Eifer","family":"Moeller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"},{"name":"Department of Cardiology, Odense University Hospital, 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Kristian Lerche","family":"Helgestad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Dall","family":"Mark","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Bispebjerg, 2400 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"M\u00f8gelvang","sequence":"additional","affiliation":[{"name":"Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-8948","authenticated-orcid":false,"given":"Martin","family":"Frydland","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"ref_1","unstructured":"GBD 2017 Causes of Death Collaborators (2018). 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