{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:28:52Z","timestamp":1788449332377,"version":"build-2803163510"},"reference-count":14,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: We aimed to describe perinatal outcomes and evaluate aspirin treatment effects in liver-transplanted pregnant women. Methods: A retrospective study examining perinatal outcomes in liver transplant recipients at a single center (2016\u20132022). The effect of low-dose aspirin treatment on the risk of developing hypertensive disease in these patients was evaluated. Results: Fourteen deliveries in 11 pregnant liver transplant recipients were identified. Primary liver disease was Wilson\u2019s in 50% of pregnancies. The median age was 23 years at transplant and 30 at conception. Tacrolimus was administered in all, steroids in 10 (71.43%), and aspirin (100 mg daily) in 7 (50.0%). Overall, two women (14.28%) developed preeclampsia, and one (7.14%) developed gestational hypertension. Median gestational age at delivery was 37 weeks (31\u201339 weeks), with six preterm births (between 31\u201336 weeks) and a median birthweight of 3004 g(range 1450\u20134100 g). None of those receiving aspirin developed hypertensive disease or suffered excessive bleeding during pregnancy, compared to two (28.57%) with pre-eclampsia in the non-aspirin group. Conclusion: Liver-transplanted pregnant women comprise a unique and complex patient population with overall favorable pregnancy outcomes. Based on our single-center experience and due to its safety profile and potential benefit, we recommend low-dose aspirin in all liver transplanted patients during pregnancy for preeclampsia prevention. Further large prospective studies are needed to corroborate our findings.<\/jats:p>","DOI":"10.3390\/jcm12113733","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T03:39:36Z","timestamp":1685331576000},"page":"3733","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Perinatal Outcomes after Liver Transplantation: Is There a Role for Aspirin Treatment?"],"prefix":"10.3390","volume":"12","author":[{"given":"Gil","family":"Zeevi","sequence":"first","affiliation":[{"name":"Helen Schneider Hospital for Women, Rabin Medical Center, 39 Jabotinsky St., Petach Tikva 4941492, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, P.O. Box 39040, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Braun","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, P.O. Box 39040, Tel Aviv 6997801, Israel"},{"name":"Liver Institute, Rabin Medical Center, 39 Jabotinsky St., Petach Tikva 4941492, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eviatar","family":"Nesher","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, P.O. Box 39040, Tel Aviv 6997801, Israel"},{"name":"Department of Organ Transplantation, Rabin Medical Center, 39 Jabotinsky St., Petach Tikva 4941492, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Wiznitzer","sequence":"additional","affiliation":[{"name":"Helen Schneider Hospital for Women, Rabin Medical Center, 39 Jabotinsky St., Petach Tikva 4941492, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, P.O. Box 39040, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-9691","authenticated-orcid":false,"given":"Asnat","family":"Walfisch","sequence":"additional","affiliation":[{"name":"Helen Schneider Hospital for Women, Rabin Medical Center, 39 Jabotinsky St., Petach Tikva 4941492, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, P.O. Box 39040, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3101-2827","authenticated-orcid":false,"given":"Eran","family":"Hadar","sequence":"additional","affiliation":[{"name":"Helen Schneider Hospital for Women, Rabin Medical Center, 39 Jabotinsky St., Petach Tikva 4941492, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, P.O. Box 39040, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7387-409X","authenticated-orcid":false,"given":"Alyssa","family":"Hochberg","sequence":"additional","affiliation":[{"name":"Helen Schneider Hospital for Women, Rabin Medical Center, 39 Jabotinsky St., Petach Tikva 4941492, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, P.O. Box 39040, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/lt.21906","article-title":"Pregnancy outcomes among liver transplant recipients in the United States: A nationwide case-control analysis","volume":"16","author":"Coffin","year":"2009","journal-title":"Liver Transplant."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.dld.2016.04.009","article-title":"AISF position paper on liver transplantation and pregnancy: Women in Hepatology Group, Italian Association for the Study of the liver (AISF)","volume":"48","author":"Alisi","year":"2016","journal-title":"Dig. Liver Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/lt.23837","article-title":"Pregnancy outcomes after living donor liver transplantation: Results from a Japanese survey","volume":"20","author":"Kubo","year":"2014","journal-title":"Liver Transplant."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/jog.13096","article-title":"Pregnancy outcomes in liver transplant recipients: A 15-year single-center experience","volume":"42","author":"Kanzaki","year":"2016","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejogrb.2022.12.032","article-title":"Clinical practice guidelines on the use of aspirin in pregnancy: Systematic review","volume":"282","author":"Alameddine","year":"2023","journal-title":"Eur. J. Obstet. Gynecol. Reprod. 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The association between chronic liver diseases and preeclampsia. BMC Pregnancy Childbirth, 22.","DOI":"10.1186\/s12884-022-04827-4"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1016\/j.transproceed.2011.08.070","article-title":"Pregnancy Outcomes Among Female Recipients After Liver Transplantation: Further Experience","volume":"43","author":"Pietrzak","year":"2011","journal-title":"Transplant. Proc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/lt.20031","article-title":"Post-liver-transplant anemia: Etiology and management","volume":"10","author":"Maheshwari","year":"2004","journal-title":"Liver Transplant."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/aogs.12455","article-title":"Prevalence of postpartum infections: A population-based observational study","volume":"93","author":"Axelsson","year":"2014","journal-title":"Acta Obstet. Gynecol. Scand."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/11\/3733\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:44:08Z","timestamp":1760125448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/11\/3733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,29]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["jcm12113733"],"URL":"https:\/\/doi.org\/10.3390\/jcm12113733","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,29]]}}}