{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:17:30Z","timestamp":1793636250672,"version":"4.5.1"},"reference-count":112,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Evidence regarding the adverse burden of severe neonatal jaundice (SNJ) in hospitalized neonates in resource-constrained settings is sparse. We attempted to determine the prevalence of SNJ, described using clinical outcome markers, in all World Health Organization (WHO) regions in the world. Data were sourced from Ovid Medline, Ovid Embase, Cochrane Library, African Journals Online, and Global Index Medicus. Hospital-based studies, including the total number of neonatal admissions with at least one clinical outcome marker of SNJ, defined as acute bilirubin encephalopathy (ABE), exchange blood transfusions (EBT), jaundice-related death, or abnormal brainstem audio-evoked response (aBAER), were independently reviewed for inclusion in this meta-analysis. Of 84 articles, 64 (76.19%) were from low- and lower-middle-income countries (LMICs), and 14.26% of the represented neonates with jaundice in these studies had SNJ. The prevelance of SNJ among all admitted neonates varied across WHO regions, ranging from 0.73 to 3.34%. Among all neonatal admissions, SNJ clinical outcome markers for EBT ranged from 0.74 to 3.81%, with the highest percentage observed in the African and South-East Asian regions; ABE ranged from 0.16 to 2.75%, with the highest percentages observed in the African and Eastern Mediterranean regions; and jaundice-related deaths ranged from 0 to 1.49%, with the highest percentage observed in the African and Eastern Mediterranean regions. Among the cohort of neonates with jaundice, the prevalence of SNJ ranged from 8.31 to 31.49%, with the highest percentage observed in the African region; EBT ranged from 9.76 to 28.97%, with the highest percentages reported for the African region; ABE was highest in the Eastern Mediterranean (22.73%) and African regions (14.51%). Jaundice-related deaths were 13.02%, 7.52%, 2.01% and 0.07%, respectively, in the Eastern Mediterranean, African, South-East Asian and European regions, with none reported in the Americas. aBAER numbers were too small, and the Western Pacific region was represented by only one study, limiting the ability to make regional comparisons. The global burden of SNJ in hospitalized neonates remains high, causing substantial, preventable morbidity and mortality especially in LMICs.<\/jats:p>","DOI":"10.3390\/jcm12113738","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T07:49:23Z","timestamp":1685346563000},"page":"3738","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Global Prevalence of Severe Neonatal Jaundice among Hospital Admissions: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8088-535X","authenticated-orcid":false,"given":"Udochukwu M.","family":"Diala","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Faculty of Clinical Sciences, College of Health Sciences, University of Jos, University of Jos Lamingo Campus, Jos 930232, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8761-953X","authenticated-orcid":false,"given":"Fatima","family":"Usman","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Clinical Services, College of Health Sciences, Bayero University, Aminu Kano Teaching Hospital Campus, Kano 700006, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duke","family":"Appiah","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Population and Public Health, Faculty of Public Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Main Campus, Zaria 810211, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolulope","family":"Ogundele","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Obafemi Awolowo University Teaching Hospital, Ile-Ife 220005, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Abdullahi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Main Campus, Zaria 810211, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-3641","authenticated-orcid":false,"given":"Katherine M.","family":"Satrom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medical School, School of Medicine, University of Minnesota, University of Minnesota Twin Cities Campus, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4154-8382","authenticated-orcid":false,"given":"Caitlin J.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Dr. John Archer Library and Archives, University of Regina, Regina, SK S4S 0A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton W.","family":"Lee","sequence":"additional","affiliation":[{"name":"National Institute of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina M.","family":"Slusher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medical School, School of Medicine, University of Minnesota, University of Minnesota Twin Cities Campus, Minneapolis, MN 55455, USA"},{"name":"Hennepin Healthcare, Minneapolis, MN 55415, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"ref_1","first-page":"33","article-title":"Acute bilirubin encephalopathy and its progression to kernicterus: Current perspectives","volume":"8","author":"Usman","year":"2018","journal-title":"Res. Rep. Neonatol."},{"key":"ref_2","first-page":"199","article-title":"The Neurological Sequelae of Neonatal Hyperbilirubinemia: Definitions, Diagnosis and Treatment of the Kernicterus Spectrum Disorders (KSDs)","volume":"13","author":"Riordan","year":"2017","journal-title":"Curr. Pediatr. Rev."},{"key":"ref_3","first-page":"746","article-title":"BIND\u2014A clinical score for bilirubin- induced neurologic dysfunction in newborns","volume":"199","author":"Johnson","year":"1999","journal-title":"Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Radmacher, P.G., Groves, F.D., Owa, J.A., Ofovwe, G.E., Amuabunos, E.A., Olusanya, B.O., and Slusher, T.M. (2015). A modified Bilirubin-induced neurologic dysfunction (BIND-M) algorithm is useful in evaluating severity of jaundice in a resource-limited setting. BMC Pediatr., 15.","DOI":"10.1186\/s12887-015-0355-2"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"114","author":"Hyperbilirubinemia","year":"2004","journal-title":"Pediatrics"},{"key":"ref_6","first-page":"SC05","article-title":"Comparison of Bilirubin Induced Neurologic Dysfunction Score with Brainstem Auditory Evoked Response in Detecting Acute Bilirubin Encephalopathy in Term Neonates","volume":"13","author":"Usman","year":"2019","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1542\/peds.114.1.e130","article-title":"An evidence-based review of important issues concerning neonatal hyperbilirubinemia","volume":"114","author":"Ip","year":"2004","journal-title":"Pediatrics"},{"key":"ref_8","unstructured":"Collaborators GCM (2016). Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980\u20132015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet, 388, 1725\u20131774."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/pr.2013.208","article-title":"Neonatal hyperbilirubinemia and Rhesus disease of the newborn: Incidence and impairment estimates for 2010 at regional and global levels","volume":"74","author":"Bhutani","year":"2013","journal-title":"Pediatr. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e000105","DOI":"10.1136\/bmjpo-2017-000105","article-title":"Burden of severe neonatal jaundice: A systematic review and meta-analysis","volume":"1","author":"Slusher","year":"2017","journal-title":"BMJ Paediatr. Open"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1136\/archdischild-2013-305506","article-title":"Why is kernicterus still a major cause of death and disability in low-income and middleincome countries?","volume":"99","author":"Olusanya","year":"2014","journal-title":"Arch. Dis. Child"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0140-6736(17)32130-X","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"Hay","year":"2017","journal-title":"Lancet"},{"key":"ref_13","unstructured":"Bank, W. (2021). The World by Income and Region, World Bank."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014A web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-7622-5-23","article-title":"Development of a quality assessment tool for systematic reviews of observational studies (QATSO) of HIV prevalence in men having sex with men and associated risk behaviours","volume":"5","author":"Wong","year":"2008","journal-title":"Emerg. Themes Epidemiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1214\/aoms\/1177729756","article-title":"Transformations Related to the Angular and the Square Root","volume":"21","author":"Freeman","year":"1950","journal-title":"Ann. Math. Stat."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/jech-2013-203104","article-title":"Meta-analysis of prevalence","volume":"67","author":"Barendregt","year":"2013","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control. Clin. Trials"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2307\/2982993","article-title":"Publication Bias\u2014A Problem in Interpreting Medical Data","volume":"151","author":"Begg","year":"1988","journal-title":"J. R. Stat. Soc. Ser. A"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.clinbiochem.2003.11.010","article-title":"An update on the prevalence of glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in Tehran neonates","volume":"37","author":"Abolghasemi","year":"2004","journal-title":"Clin. Biochem."},{"key":"ref_22","first-page":"36","article-title":"A review of neonatal admissions in Osogbo, Southwestern Nigeria","volume":"5","author":"Adebami","year":"2010","journal-title":"Niger. Hosp. Pract."},{"key":"ref_23","first-page":"347","article-title":"Factors associated with the incidence of acute bilirubin encephalopathy in Nigerian population","volume":"9","author":"Adebami","year":"2011","journal-title":"J. Pediatr. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3126\/jnhrc.v15i2.18203","article-title":"Morbidities and Outcome of a Neonatal Intensive Care in Western Nepal","volume":"15","author":"Adhikari","year":"2017","journal-title":"J. Nepal Health Res. Counc."},{"key":"ref_25","first-page":"118","article-title":"Exchange transfusion through peripheral route","volume":"12","author":"Ahmed","year":"2005","journal-title":"JK-Practitioner."},{"key":"ref_26","first-page":"41","article-title":"Pattern and Outcome of Newborn Emergencies in a Tertiary Center, Lagos, Nigeria","volume":"10","author":"Akintan","year":"2019","journal-title":"Iran. J. Neonatol. IJN"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/s41372-020-00782-0","article-title":"Clinical decision support tool for phototherapy initiation in preterm infants","volume":"40","author":"Arain","year":"2020","journal-title":"J. Perinatol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Arnolda, G., Thein, A.A., Trevisanuto, D., Aung, N., New, H.M., Thin, A.A., Aye, N.S.S., Defechereux, T., Kumara, D., and Moccia, L. (2015). Evaluation of a simple intervention to reduce exchange transfusion rates among inborn and outborn neonates in Myanmar, comparing pre- and post-intervention rates. BMC Pediatr., 15.","DOI":"10.1186\/s12887-015-0530-5"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/tropej\/fmi042","article-title":"Glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia","volume":"52","author":"Atay","year":"2006","journal-title":"J Trop Pediatr"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/BJMMR\/2016\/26551","article-title":"Identifying Modifiable Socio-demographic Risk Factors for Severe Hyperbilirubinaemia in Late Preterm and Term Babies in Abuja, Nigeria","volume":"16","author":"Audu","year":"2016","journal-title":"BJMMR"},{"key":"ref_31","first-page":"285","article-title":"Universal Bilirubin Screening: A new hope to limit exchange transfusion in severe hyperbilirubinemia","volume":"113","author":"Bakhru","year":"2018","journal-title":"Iran. J. Pediatr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/2249-4847.191245","article-title":"Critical appraisal of journal article by psychiatry PG residents using a new module: Impact analysis","volume":"5","author":"Bhat","year":"2016","journal-title":"J. Clin. Neonatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.clp.2016.01.001","article-title":"Hyperbilirubinemia in Preterm Neonates","volume":"43","author":"Bhutani","year":"2016","journal-title":"Clin. Perinatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4103\/jcn.JCN_27_18","article-title":"Morbidity and mortality patterns among outborn referral neonates in central India: Prospective observational study","volume":"7","author":"Bokade","year":"2018","journal-title":"J. Clin. Neonatol."},{"key":"ref_35","first-page":"103","article-title":"Severe neonatal hyperbilirubinemia in the southeast region of Turkey","volume":"50","author":"Bozkurt","year":"2020","journal-title":"Turk. J. Med. Sci."},{"key":"ref_36","first-page":"93","article-title":"Adverse events associated with exchange transfusion and etiology of severe hyperbilirubinemia in near-term and term newborns","volume":"41","author":"Okan","year":"2011","journal-title":"Turk. J. Med. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/jpc.12193","article-title":"Glucose-6-phosphate dehydrogenase deficiency in neonatal hyperbilirubinaemia: Hacettepe exper\u0131ence","volume":"49","author":"Celik","year":"2013","journal-title":"J. Paediatr. Child Health"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/inthealth\/ihy045","article-title":"Neonatal exchange transfusions at a tertiary care centre in north India: An investigation of historical trends using change-point analysis and statistical process control","volume":"10","author":"Chhapola","year":"2018","journal-title":"Int. Health"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4274\/jpr.galenos.2019.16779","article-title":"The Neurodevelopmental outcome of severe Neonatal Hemolytic and Nonhemolytic Hyperbilirubinemia","volume":"7","author":"Colak","year":"2020","journal-title":"J. Pediatr. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/j.1651-2227.2011.02170.x","article-title":"High-intensity phototherapy for the treatment of severe nonhaemolytic neonatal hyperbilirubinemia","volume":"100","author":"Mochdece","year":"2011","journal-title":"Acta Paediatrica."},{"key":"ref_41","first-page":"136","article-title":"Pattern of Neonatal Mortality in a Teritiary Health Facility in Umuahia, South East, Nigeria","volume":"42","author":"Eke","year":"2013","journal-title":"Int. J. Trop. Dis. Health"},{"key":"ref_42","first-page":"s1","article-title":"Bilirubin encepahlopathy (kernicterus) among full term Lybian infants","volume":"39","author":"Shlmani","year":"2013","journal-title":"Intensive Care Med."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Emokpae, A.A., Mabogunje, C.A., Imam, Z.O., and Olusanya, B.O. (2016). Heliotherapy for Neonatal Hyperbilirubinemia in Southwest, Nigeria: A Baseline Pre-Intervention Study. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0151375"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4314\/phmedj.v2i2.38906","article-title":"Neonatal jaundice in a Special Care Baby Unit (SCBU) in Port Harcourt, Nigeria: A prospective study","volume":"2","author":"Eneh","year":"2008","journal-title":"Port Harcourt Med. J."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Erdeve, O., Okulu, E., Olukman, O., Ulubas, D., Buyukkale, g., Narter, F., Tunc, G., Atasay, B., Gultekin, N.D., and Arsan, S. (2018). The Turkish Neonatal Jaundice Online Registry: A national root cause analysis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193108"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8707652","DOI":"10.1155\/2020\/8707652","article-title":"When Do Newborns Die? Timing and Cause-Specific Neonatal Death in Neonatal Intensive Care Unit at Referral Hospital in Gedeo Zone: A Prospective Cohort Study","volume":"2020","author":"Eshete","year":"2020","journal-title":"Int. J. Pediatr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13031-020-00297-7","article-title":"Morbidities & outcomes of a neonatal intensive care unit in a complex humanitarian conflict setting, Hajjah Yemen: 2017\u20132018","volume":"14","author":"Eze","year":"2020","journal-title":"Confl. Health"},{"key":"ref_48","first-page":"299","article-title":"Outcome of low birth weight neonates in a tertiary health care centre in Lagos, Nigeria","volume":"33","author":"Ezeaka","year":"2004","journal-title":"Afr. J. Med. Med. Sci."},{"key":"ref_49","first-page":"17","article-title":"Why our children die: A review of paediatric mortality in a tertiary centre in Lagos, Nigeria","volume":"13","author":"Ezeaka","year":"2005","journal-title":"Niger. Q. J. Hosp. Med."},{"key":"ref_50","first-page":"10","article-title":"Outborns or inborns: Clinical audit of the two intensive care units of Cairo University Hospital","volume":"65","author":"Fahmy","year":"2017","journal-title":"Egypt. Pediatr. Assoc. Gaz."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1542\/hpeds.2018-0136","article-title":"Phototherapy for Neonatal Unconjugated Hyperbilirubinemia: Examining Outcomes by Level of Care","volume":"9","author":"Fein","year":"2019","journal-title":"Hosp. Pediatr."},{"key":"ref_52","first-page":"131","article-title":"Childhood mortality in children emergency centre of the Lagos University Teaching hospital","volume":"38","author":"Fajolu","year":"2011","journal-title":"Niger. J. Paed."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4314\/njp.v44i2.1","article-title":"Glucose-6-phosphate dehydrogenase deficiency; the single most important cause of neonatal hyperbilirubinaemia in Kano, Nigeria","volume":"44","author":"Farouk","year":"2017","journal-title":"Niger. J. Paediatr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/tropej\/fmx041","article-title":"Follow-up of Children with Kernicterus in Kano, Nigeria","volume":"64","author":"Farouk","year":"2018","journal-title":"J. Trop. Pediatr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2147\/PHMT.S235591","article-title":"Prevalence and Factors Associated with Neonatal Mortality at Ayder Comprehensive Specialized Hospital, Northern Ethiopia. A Cross-Sectional Study","volume":"11","author":"Hadgu","year":"2020","journal-title":"Pediatr. Health Med. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.3109\/14767058.2014.960832","article-title":"Exchange transfusion for neonatal hyperbilirubinemia: An 8-year single center experience at a tertiary neonatal intensive care unit in Turkey","volume":"28","author":"Hakan","year":"2015","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3109\/14767058.2013.825595","article-title":"The use of continuous positive airway pressure in preterm babies with respiratory distress syndrome: A report from Baghdad, Iraq","volume":"27","author":"Hameed","year":"2014","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Hanson, C., Singh, S., Zamboni, K., Tyagi, M., Chamarty, S., Shukla, R., and Schellenberg, J. (2019). Care practices and neonatal survival in 52 neonatal intensive care units in Telangana and Andhra Pradesh, India: A cross-sectional study. PLoS Med., 16.","DOI":"10.1371\/journal.pmed.1002860"},{"key":"ref_59","first-page":"34","article-title":"Short-term neonatal outcome in late preterm vs. term infants","volume":"24","author":"Haroon","year":"2014","journal-title":"J. Coll. Physicians Surg. Pak. JCPSP"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12519-018-0200-4","article-title":"Characteristics and outcome of newborn admitted with acute bilirubin encephalopathy to a tertiary neonatal intensive care unit","volume":"15","author":"Helal","year":"2019","journal-title":"World J. Pediatr. WJP"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4103\/2249-4847.92239","article-title":"Outcome of exchange blood transfusions done for neonatal jaundice in abakaliki, South eastern Nigeria","volume":"1","author":"Ibekwe","year":"2012","journal-title":"J. Clin. Neonatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/2249-4847.191245","article-title":"Efficacy of different types of phototherapy devices: A 3-year prospective study from Northern India","volume":"5","author":"Iqbal","year":"2016","journal-title":"J. Clin. Neonatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3345\/kjp.2017.60.4.106","article-title":"Neonatal indirect hyperbilirubinemia and glucose-6-phosphate dehydrogenase deficiency","volume":"60","author":"Isa","year":"2017","journal-title":"Korean J. Pediatr."},{"key":"ref_64","first-page":"159","article-title":"Risk factors for neonatal jaundice in babies presenting at the University of Benin Teaching Hospital, Benin City","volume":"39","author":"Omoigberale","year":"2012","journal-title":"Niger. J. Paed."},{"key":"ref_65","first-page":"A149","article-title":"IDDF2019-ABS-0222\u2005Exchange transfusion in neonatal hyperbilirubinemia and bilirubin encephalopathy: A long way to go","volume":"68","author":"Jajoo","year":"2019","journal-title":"Gut"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pedneo.2013.10.006","article-title":"Is it accurate to separate glucose-6-phosphate dehydrogenase activity in neonatal hyperbilirubinemia as deficient and normal?","volume":"55","author":"Kilicdag","year":"2014","journal-title":"Pediatr. Neonatol."},{"key":"ref_67","first-page":"282","article-title":"Study of the morbidity and the mortality patterns in the neonatal intensive care unit at a tertiary care teaching Hospital in Rohtas District, Bihar, India","volume":"6","author":"Kumar","year":"2012","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3126\/kumj.v13i2.16781","article-title":"A Prospective Study on Exchange Transfusion in Neonatal Unconjugated Hyperbilirubinemia\u2014In a Tertiary Care Hospital, Nepal","volume":"13","author":"Malla","year":"2015","journal-title":"Kathmandu Univ. Med. J. (KUMJ)"},{"key":"ref_69","first-page":"40","article-title":"Why our neonates are dying? Pattern and outcome of admissions to neonatal units of tertiary care hospitals in Peshawar from January, 2009 to December, 2011","volume":"66","author":"Malik","year":"2016","journal-title":"JPMA J. Pak. Med. Assoc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3126\/jnps.v36i3.12155","article-title":"Hearing evaluation of neonates with hyperbilirubinemia by otoacoustic emissions and brain stem evoked response audiometry","volume":"36","author":"Mirajkar","year":"2016","journal-title":"J. Nepal. Paediatr. Soc."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Mmbaga, B.T., Lie, R.T., Olomi, R., Mahande, M.J., Kvale, G., and Daltveit, A.K. (2012). Cause-specific neonatal mortality in a neonatal care unit in Northern Tanzania: A registry based cohort study. BMC Pediatr., 12.","DOI":"10.1186\/1471-2431-12-116"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4314\/ahs.v20i1.46","article-title":"Prevalence, factors associated and treatment outcome of hyperbilirubinaemia in neonates admitted to St Francis hospital, Nsambya, Uganda: A descriptive study","volume":"20","author":"Mworozi","year":"2020","journal-title":"Afr. Health Sci."},{"key":"ref_73","first-page":"9","article-title":"Prevalence of Bilirubin Encephalopathy in Calabar, South-South Nigeria: A Five-year Review Study","volume":"7","author":"Ochigbo","year":"2016","journal-title":"Iran. J. Neonatol. IJN"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/20786190.2019.1622857","article-title":"Factors associated with clinical outcomes among neonates admitted with acute bilirubin and hypoxic-ischaemic encephalopathies at a tertiary hospital in south-west Nigeria","volume":"61","author":"Ogunfowora","year":"2019","journal-title":"South Afr. Fam. Pract."},{"key":"ref_75","first-page":"354","article-title":"The incidence and outcome of bilirubin encephalopathy in Nigeria: A bi-centre study","volume":"16","author":"Ogunlesi","year":"2007","journal-title":"Niger. J. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/tropej\/fmq045","article-title":"Predictors of Acute Bilirubin Encephalopathy Among Nigerian Term Babies with Moderate-to-severe Hyperbilirubinaemia","volume":"57","author":"Ogunlesi","year":"2011","journal-title":"J. Trop. Pediatr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.4314\/ahs.v19i4.26","article-title":"The current pattern of facility-based perinatal and neonatal mortality in Sagamu, Nigeria","volume":"19","author":"Ogunlesi","year":"2019","journal-title":"Afr. Health Sci."},{"key":"ref_78","first-page":"2","article-title":"Analysis and outcome of admissions in the Special Care Baby Unit of the Ebonyi State University Teaching Hospital, Abakaliki","volume":"9","author":"Ojukwu","year":"2004","journal-title":"Int. J. Med. Health Dev."},{"key":"ref_79","first-page":"259","article-title":"Morbidity and Mortality Pattern of Neonates admitted into the Special Care Baby Unit of University of Port Harcourt Teaching Hospital, Nigeria","volume":"94","author":"Okagua","year":"2017","journal-title":"East Afr. Med. J."},{"key":"ref_80","first-page":"389","article-title":"Morbidity and mortality patterns of admissions into the Special Care Baby Unit of University of Abuja Teaching Hospital, Gwagwalada, Nigeria","volume":"12","author":"Okechukwu","year":"2009","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_81","first-page":"21","article-title":"Exchange Blood Transfusion in a Nigerian Teaching Hospital","volume":"9","author":"Onyearugha","year":"2014","journal-title":"Int. J. Trop. Med."},{"key":"ref_82","first-page":"4","article-title":"The Pattern and Outcome of Newborn Admissions in Benin City","volume":"11","author":"Osaghae","year":"2013","journal-title":"Niger. Hosp. Pract."},{"key":"ref_83","first-page":"50","article-title":"Prevalence of exchange blood transfusion in severe hyper- bilirubinaemia and outcome at the University of Maiduguri Teaching Hospital Maiduguri, North-eastern Nigeria","volume":"44","author":"Pius","year":"2017","journal-title":"Niger. J. Paed."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3126\/jnps.v29i2.2040","article-title":"Maternal Risk Factors and Morbidity Pattern of Very Low Birth Weight Infants: A NICU Based Study at Eastern Nepal","volume":"29","author":"Poudel","year":"2009","journal-title":"J. Nepal Paediatr. Soc."},{"key":"ref_85","first-page":"40","article-title":"Outcome of neonatal hyperbilirubinemia in a tertiary care hospital in bangladesh","volume":"17","author":"Rasul","year":"2010","journal-title":"Malays. J. Med. Sci."},{"key":"ref_86","first-page":"205","article-title":"Overview of neonatal hyperbilirubinemia at Nepal Medical College Teaching Hospital","volume":"13","author":"Rijal","year":"2011","journal-title":"Nepal Med. Coll. J."},{"key":"ref_87","first-page":"37","article-title":"Early outcome of pre-term neonates delivered at Soba University Hospital","volume":"13","author":"Salih","year":"2013","journal-title":"Sudan. J. Paediatr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1651-2227.2008.00743.x","article-title":"Exchange transfusion in infants with extreme hyperbilirubinemia: An experience from a developing country","volume":"97","author":"Salas","year":"2008","journal-title":"Acta Paediatr."},{"key":"ref_89","first-page":"611","article-title":"Morbidity and mortality of neonates admitted in general paediatric wards at Kenyatta National Hospital","volume":"80","author":"Simiyu","year":"2003","journal-title":"East Afr. Med. J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4314\/eamj.v81i7.9193","article-title":"Morbidity and mortality of low birth weight infants in the new born unit of Kenyatta National Hospital, Nairobi","volume":"81","author":"Simiyu","year":"2004","journal-title":"East Afr. Med. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cegh.2016.03.006","article-title":"Etiology and clinical profile of neonates with pathological unconjugated hyperbilirubinemia with special reference to Rhesus (Rh) D, C, and E incompatibilities: A tertiary care center experience","volume":"4","author":"Singh","year":"2016","journal-title":"Clin. Epidemiol. Glob. Health"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4103\/ijabmr.IJABMR_298_16","article-title":"Evaluation of Risk Factors for Exchange Range Hyperbilirubinemia and Neurotoxicity in Neonates from Hilly Terrain of India","volume":"7","author":"Singla","year":"2017","journal-title":"Int. J. Appl. Basic Med. Res."},{"key":"ref_93","first-page":"1","article-title":"Prevalence of risk factors for sensorineural hearing loss in NICU newborns","volume":"8","author":"Speleman","year":"2012","journal-title":"B-ent"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12098-012-0818-5","article-title":"Mortality and morbidity in extremely low birth weight (ELBW) infants in a neonatal intensive care unit","volume":"80","author":"Tagare","year":"2013","journal-title":"Indian J. Pediatr."},{"key":"ref_95","first-page":"330","article-title":"Auditory Evaluation of High Risk Newborns by Automated Auditory Brain Stem Response","volume":"18","author":"Taghdiri","year":"2008","journal-title":"Iran. J. Pediatr."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Tette, E.M.A., Nartey, E.T., Nuertey, B.D., Azusong, E.A., Akaateba, D., Yirifere, J., Alandu, A., Seneadza, A.A.H., Gandau, N.B., and Renner, l.A. (2020). The pattern of neonatal admissions and mortality at a regional and district hospital in the Upper West Region of Ghana; a cross sectional study. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0232406"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1111\/apa.14837","article-title":"Prevalence and risk factors for hearing loss in high-risk neonates in Germany","volume":"108","author":"Thangavelu","year":"2019","journal-title":"Acta Paediatr."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Thielemans, L., Trip-Hoving, M., Landier, J., Turner, C., Prins, T.J., Wouda, E.M.N., Hanboonkunupakam, B., Po, C., Beau, C., and Mu, M. (2018). Indirect neonatal hyperbilirubinemia in hospitalized neonates on the Thai-Myanmar border: A review of neonatal medical records from 2009 to 2014. BMC Pediatr., 18.","DOI":"10.1186\/s12887-018-1165-0"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Turner, C., Carrara, V., Aye Mya Thein, N., Chit Mo Mo Win, N., Turner, P., Bancone, G., White, N.J., McGready, R., and Nosten, F. (2013). Neonatal intensive care in a Karen refugee camp: A 4 year descriptive study. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072721"},{"key":"ref_100","first-page":"285","article-title":"Neonatal morbidity and mortality in Calabar, Nigeria: A hospital-based study","volume":"11","author":"Udo","year":"2008","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_101","first-page":"75","article-title":"Preterm Admissions in a Special Care Baby Unit: The Nnewi Experience","volume":"29","author":"Ugochukwu","year":"2002","journal-title":"Niger. J. Paediatr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e000641","DOI":"10.1136\/bmjpo-2020-000641","article-title":"Extreme neonatal hyperbilirubinaemia in refugee and migrant populations: Retrospective cohort","volume":"4","author":"Wouda","year":"2020","journal-title":"BMJ Paediatr. Open"},{"key":"ref_103","first-page":"9","article-title":"A clinical prediction rule for acute bilirubin encephalopathy in neonates with extreme hyperbilirubinemia: A retrospective cohort study","volume":"99","author":"Zhang","year":"2020","journal-title":"Medicine"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/j.semperi.2014.08.002","article-title":"The enigma of low bilirubin kernicterus in premature infants: Why does it still occur, and is it preventable?","volume":"38","author":"Watchko","year":"2014","journal-title":"Semin. Perinatol."},{"key":"ref_105","first-page":"1","article-title":"Availability and distribution of phototherapy services and health care providers for neonatal jaundice in three local government areas in Jos, North\u2014Central Nigeria","volume":"45","author":"Toma","year":"2018","journal-title":"Niger. J. Paed."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.earlhumdev.2017.09.008","article-title":"Filtered sunlight, solar powered phototherapy and other strategies for managing jaundice in low-resource settings","volume":"114","author":"Slusher","year":"2017","journal-title":"Early Hum. Dev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1053\/j.semperi.2011.02.014","article-title":"A global need for affordable neonatal jaundice technologies","volume":"35","author":"Slusher","year":"2011","journal-title":"Semin. Perinatol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jpeds.2020.01.050","article-title":"Maternal Instruction About Jaundice and the Incidence of Acute Bilirubin Encephalopathy in Nigeria","volume":"221","author":"Wennberg","year":"2020","journal-title":"J. Pediatr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"151353","DOI":"10.1016\/j.semperi.2020.151353","article-title":"Acute bilirubin encephalopathy: Some lessons learned","volume":"45","author":"Iskander","year":"2021","journal-title":"Semin. Perinatol."},{"key":"ref_110","unstructured":"Health FMO (2016). Nigeria Every Newborn Action Plan: Aplan to End Preventable Newborn Deaths in Nigeria, Federal Ministry of Health."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1542\/peds.2022-058859","article-title":"Clinical practice guideline revision: Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"150","author":"Kemper","year":"2022","journal-title":"Pediatrics"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e2022060679","DOI":"10.1542\/peds.2022-060679","article-title":"Relevance of the 2022 American Academy of Pediatrics Hyperbilirubinemia Guidelines for an LMIC","volume":"151","author":"Slusher","year":"2023","journal-title":"Pediatrics"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/11\/3738\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:44:18Z","timestamp":1760125458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/11\/3738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,29]]},"references-count":112,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["jcm12113738"],"URL":"https:\/\/doi.org\/10.3390\/jcm12113738","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,29]]}}}