{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:15:03Z","timestamp":1760148903622,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The role of anterior vertebral body tethering (aVBT) in obviating the need for spinal fusion in patients with AIS remains unclear, and a large amount of variation exists in the data among different studies. The present study aims to investigate and analyze what factors have a potential influence on aVBT outcome. Skeletally immature patients with AIS who underwent aVBT for scoliosis correction were followed up until skeletal maturity. The mean age at the time of surgery was 13.4 \u00b1 1.1, and the mean follow-up time was 2.5 \u00b1 0.5 years. The Cobb angle of the main curve was 46.6 \u00b1 9\u00b0 at the time of surgery and was significantly corrected to 17.7 \u00b1 10.4\u00b0 (p &lt; 0.001) immediately postoperatively. A significant loss of correction was observed during the latest follow-up (Cobb angle 33.8 \u00b1 18.7\u00b0; p &lt; 0.001). An indication for spinal fusion at skeletal maturity was not obviated in 60% of the patients. The factors identified as having an influence on the outcome were preoperative bone age and the magnitude of the major curve. Patients with advanced bone age and larger curves were more likely to reach an indication for spinal fusion at skeletal maturity. In conclusion, no general recommendation for aVBT can be made for AIS patients. The method can be discussed as a treatment option in skeletally very immature preadolescent patients (Sanders Stadium \u2264 2) with a moderate Cobb angle (\u226450\u00b0) who failed previous brace therapy.<\/jats:p>","DOI":"10.3390\/jcm12123933","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T02:03:18Z","timestamp":1686276198000},"page":"3933","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anterior Vertebral Body Tethering for Skeletally Immature Patients with AIS: Indication for Spinal Fusion at Skeletal Maturity Is Not Obviated in 60% of Cases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2875-6291","authenticated-orcid":false,"given":"Kiril V.","family":"Mladenov","sequence":"first","affiliation":[{"name":"Pediatric Orthopedic Department, Altona Children\u2019s Hospital, Bleickenallee 38, D-22763 Hamburg, Germany"},{"name":"Department of Orthopedics, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans O.","family":"Pinnschmidt","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine, Institute for Medical Biometry & Epidemiology, University Medical Center Hamburg-Eppendorf, Chrisoph-Probst-Weg 1, D-20246 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"St\u00fccker","sequence":"additional","affiliation":[{"name":"Pediatric Orthopedic Department, Altona Children\u2019s Hospital, Bleickenallee 38, D-22763 Hamburg, Germany"},{"name":"Department of Orthopedics, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11832-012-0462-7","article-title":"Natural history of adolescent idiopathic scoliosis: A tool for guidance in decision of surgery of curves above 50 degrees","volume":"7","author":"Danielsson","year":"2013","journal-title":"J. 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