{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:19:10Z","timestamp":1788013150079,"version":"build-2784847793"},"reference-count":12,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Hypoglycemia in patients without diabetes is a diagnostic challenge for the endocrinologist. Sometimes it is related to rare causes such as Doege\u2013Potter Syndrome (DPS). DPS is caused by an abnormal insulin-like grow factor 2(IGF-2) that retains part of the E domain during the production process, resulting in a longer peptide called \u201cbig-IGF-2\u201d. We present a case report of DPS with emphasis on the diagnosis and especially on the difficulties in interpreting the biochemical findings. An elderly patient with an intrathoracic neoplasm and hypoglycemia underwent various tests: insulin autoantibodies and fasting test were both negative. She had low values of IGF-1 and normal values of IGF-2 that apparently excludes a diagnosis of DPS. The evaluation of the IGF-2\/IGF-1 ratio is the most important test because a ratio &gt;10 is widely considered to be indicative of non-islet cell tumor hypoglycemia (NICTH). Glucose infusion and steroid therapy were used to control the hypoglycemia, but the definitive treatment was surgery, which almost immediately reversed the hypoglycemia. The differential diagnosis of hypoglycemia should include rare causes such as DPS, and the IGF-2\/IGF-1 ratio is a useful tool.<\/jats:p>","DOI":"10.3390\/jcm12123984","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T01:59:07Z","timestamp":1686535147000},"page":"3984","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Case Report of Doege\u2013Potter Syndrome: A Rare Cause of Hypoglycemia in a Patient without Diabetes"],"prefix":"10.3390","volume":"12","author":[{"given":"Chiara","family":"Corsano","sequence":"first","affiliation":[{"name":"Endocrinology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Paradiso","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Daniela","family":"Laudadio","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-0965","authenticated-orcid":false,"given":"Francesco","family":"Sollitto","sequence":"additional","affiliation":[{"name":"Institute of Thoracic Surgery, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Lamacchia","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1210\/jc.2008-1410","article-title":"Evaluation and Management of Adult Hypoglycemic Disorders: An Endocrine Society Clinical Practice Guideline","volume":"94","author":"Cryer","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1159\/000512823","article-title":"Doege-Potter Syndrome with a Benign Solitary Fibrous Tumor: A Case Report and Literature Review","volume":"14","author":"Mohammed","year":"2021","journal-title":"Case Rep. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1308\/rcsann.2015.0023","article-title":"Doege-Potter Syndrome","volume":"97","author":"Ahluwalia","year":"2015","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e2021412","DOI":"10.4322\/acr.2021.412","article-title":"Doege-Potter syndrome associated to metastatic solitary fibrous tumor","volume":"12","author":"Andrade","year":"2022","journal-title":"Autopsy Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21926\/obm.genet.1904096","article-title":"Insulin-Like Growth Factor 2 in Physiology, Cancer, and Cancer Treatment","volume":"3","author":"Szuhai","year":"2019","journal-title":"OBM Genet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1038\/s41467-022-32214-2","article-title":"Structural basis for assembly and disassembly of the IGF\/IGFBP\/ALS ternary complex","volume":"13","author":"Kim","year":"2022","journal-title":"Nat. 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