{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:08:34Z","timestamp":1785024514909,"version":"3.55.0"},"reference-count":36,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Neck pain (NP) is a prevalent symptom among migraine patients, but its disability on headache impact and the contributing factors for comorbid NP are poorly understood. This study aimed to investigate NP disability on the impact of headaches among migraineurs and factors linked to comorbid NP, including sleep-related variables. This cross-sectional study was conducted at a university hospital headache center, for headache patients at their first visits. Included in the study were 295 patients with migraines (217 females; 39.0\u2009 \u00b1 \u200910.8\u2009years; 101 chronic migraine). Information on NP, history of physician-diagnosed cervical spine or disc disorders, detailed parameters of headache, and sleep and mood variables were collected. Logistic analysis of the severe impact of headache and contributing factors for NP were performed. NP was present in 153 participants (51.9%) with migraine, with high NP disability observed in 28 patients, and 125 patients had low NP disability. In multivariable analysis, NP disability, medication days per month, severe disability of migraine, and excessive daytime sleepiness were significant predictors for severe impact of headache. Thirty-seven patients with physician-diagnosed cervical spine or disc disorders were excluded from the NP analysis. Higher monthly headache days, female gender, and a high likelihood of obstructive sleep apnea were positively correlated with the presence of NP among migraineurs in multivariable analysis. Overall, the study highlights the potential impact of sleep-related variables and monthly headache days on NP in these patients. The high disability of NP was also associated with severe impact of headache.<\/jats:p>","DOI":"10.3390\/jcm12123989","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T02:28:42Z","timestamp":1686536922000},"page":"3989","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neck Pain Disability on Headache Impact and the Association between Sleep Disturbance and Neck Pain in Migraine"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8979-6521","authenticated-orcid":false,"given":"Hee-Jin","family":"Im","sequence":"first","affiliation":[{"name":"Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University Medical Center, Hwaseong 18450, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-2831","authenticated-orcid":false,"given":"Yoo-Ha","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University Medical Center, Hwaseong 18450, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4053-3763","authenticated-orcid":false,"given":"Soo-Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University Medical Center, Hwaseong 18450, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"ref_1","unstructured":"GBD 2019 Diseases and Injuries Collaborators (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet, 396, 1204\u20131222."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"m791","DOI":"10.1136\/bmj.m791","article-title":"Global, regional, and national burden of neck pain in the general population, 1990\u20132017: Systematic analysis of the Global Burden of Disease Study 2017","volume":"368","author":"Safiri","year":"2020","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"955367","DOI":"10.3389\/fneur.2022.955367","article-title":"Global, regional, and national neck pain burden in the general population, 1990\u20132019: An analysis of the global burden of disease study 2019","volume":"13","author":"Shin","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1468-2982.2008.01609.x","article-title":"Comparison of cervicogenic headache with migraine","volume":"28","author":"Evers","year":"2008","journal-title":"Cephalalgia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1177\/0333102414535110","article-title":"Prevalence of neck pain in migraine and tension-type headache: A population study","volume":"35","author":"Ashina","year":"2015","journal-title":"Cephalalgia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s10194-017-0753-y","article-title":"Level of physical activity, well-being, stress and self-rated health in persons with migraine and co-existing tension-type headache and neck pain","volume":"18","author":"Hammarlund","year":"2017","journal-title":"J. Headache Pain"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1177\/03331024211068073","article-title":"Prevalence of neck pain in migraine: A systematic review and meta-analysis","volume":"42","author":"Younis","year":"2022","journal-title":"Cephalalgia"},{"key":"ref_8","first-page":"262","article-title":"Relationships of daily stress, sleep, and headache: A time-series analysis","volume":"21","author":"Penzien","year":"2001","journal-title":"Cephalalgia Int. J. Headache"},{"key":"ref_9","first-page":"593","article-title":"Factors associated with increased risk for clinical insomnia in patients with chronic neck pain","volume":"18","author":"Kim","year":"2015","journal-title":"Pain Physician"},{"key":"ref_10","first-page":"1","article-title":"Prevalence of sleep deprivation in patients with chronic neck and back pain: A retrospective evaluation of 1016 patients","volume":"6","author":"Artner","year":"2013","journal-title":"J. Pain Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/head.13123","article-title":"The Clinical Features, Risk Factors, and Surgical Treatment of Cervicogenic Headache in Patients with Cervical Spine Disorders Requiring Surgery","volume":"57","author":"Shimohata","year":"2017","journal-title":"Headache"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.clineuro.2017.05.016","article-title":"Atypical presentation and outcome of cervicogenic headache in patients with cervical degenerative disease: A single-center experience","volume":"159","author":"Bir","year":"2017","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"(2012). The International Headache Society\u2019s Core Curriculum on Headache for Neurologists. Br. J. Pain, 6, 103\u2013105.","DOI":"10.1177\/2049463712454809"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/0333102410379890","article-title":"Validation of the Headache Impact Test (HIT-6\u2122) across episodic and chronic migraine","volume":"31","author":"Yang","year":"2011","journal-title":"Cephalalgia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1468-2982.1999.019002107.x","article-title":"Reliability of the migraine disability assessment score in a population-based sample of headache sufferers","volume":"19","author":"Stewart","year":"1999","journal-title":"Cephalalgia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.jmpt.2008.11.007","article-title":"A new conceptual model of neck pain: Linking onset, course, and care: The Bone and Joint Decade 2000\u20132010 Task Force on Neck Pain and Its Associated Disorders","volume":"32","author":"Guzman","year":"2009","journal-title":"J. Manip. Physiol. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0304-3959(92)90154-4","article-title":"Grading the severity of chronic pain","volume":"50","author":"Ormel","year":"1992","journal-title":"Pain"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness: The Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1378\/chest.15-0903","article-title":"STOP-Bang questionnaire: A practical approach to screen for obstructive sleep apnea","volume":"149","author":"Chung","year":"2016","journal-title":"Chest"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1389-9457(00)00065-4","article-title":"Validation of the Insomnia Severity Index as an outcome measure for insomnia research","volume":"2","author":"Bastien","year":"2001","journal-title":"Sleep Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3928\/0048-5713-20020901-06","article-title":"The PHQ-9: A new depression diagnostic and severity measure","volume":"32","author":"Kroenke","year":"2002","journal-title":"Psychiatr. Ann."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.berh.2011.01.019","article-title":"The epidemiology of neck pain","volume":"24","author":"Hoy","year":"2010","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/0333102419896369","article-title":"Ictal neck pain investigated in the interictal state\u2014A search for the origin of pain","volume":"40","author":"Hvedstrup","year":"2020","journal-title":"Cephalalgia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1526-4610.2009.01608.x","article-title":"The prevalence of neck pain in migraine","volume":"50","author":"Calhoun","year":"2010","journal-title":"Headache J. Head Face Pain"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"pzac027","DOI":"10.1093\/ptj\/pzac027","article-title":"The Neck Disability Index Reflects Allodynia and Headache Disability but Not Cervical Musculoskeletal Dysfunction in Migraine","volume":"102","author":"Liang","year":"2022","journal-title":"Phys. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fneur.2019.00276","article-title":"A Neuroscience Perspective of Physical Treatment of Headache and Neck Pain","volume":"10","author":"Castien","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.neuroscience.2006.08.015","article-title":"Muscle inflammation induces a rapid increase in calcitonin gene-related peptide (CGRP) mRNA that temporally relates to CGRP immunoreactivity and nociceptive behavior","volume":"143","author":"Ambalavanar","year":"2006","journal-title":"Neuroscience"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1097\/MCP.0000000000000325","article-title":"Comorbidities of chronic facial pain and obstructive sleep apnea","volume":"22","author":"Olmos","year":"2016","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1093\/pm\/pny140","article-title":"The association of obstructive sleep apnea and pain outcomes in adults: A systematic review","volume":"19","author":"Charokopos","year":"2018","journal-title":"Pain Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1159\/000075218","article-title":"Inflammation and obstructive sleep apnea syndrome pathogenesis: A working hypothesis","volume":"70","author":"Rubinstein","year":"2003","journal-title":"Respiration"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/sleep\/25.3.268","article-title":"The effect of sleep fragmentation on daytime function","volume":"25","author":"Stepanski","year":"2002","journal-title":"Sleep"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"515","DOI":"10.5665\/sleep.3488","article-title":"Sleep fragmentation exacerbates mechanical hypersensitivity and alters subsequent sleep-wake behavior in a mouse model of musculoskeletal sensitization","volume":"37","author":"Sutton","year":"2014","journal-title":"Sleep"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Waliszewska-Pros\u00f3\u0142, M., Nowakowska-Kotas, M., Chojdak-\u0141ukasiewicz, J., and Budrewicz, S. (2021). Migraine and Sleep\u2014An Unexplained Association?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115539"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/head.13358","article-title":"Sleep Disorders and Migraine: Review of Literature and Potential Pathophysiology Mechanisms","volume":"58","author":"Vgontzas","year":"2018","journal-title":"Headache"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1046\/j.1526-4610.1998.3806442.x","article-title":"Cervicogenic headache: Diagnostic criteria. The Cervicogenic Headache International Study Group","volume":"38","author":"Sjaastad","year":"1998","journal-title":"Headache"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1129-2377-16-6","article-title":"Cervicogenic headache: Too important to be left un-diagnosed","volume":"16","author":"Fredriksen","year":"2015","journal-title":"J. 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