{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:35Z","timestamp":1787028635507,"version":"build-2736575974"},"reference-count":19,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Investigator Initiated Research grant from Takeda Pharmaceuticals International AG, a member of the Takeda group of companies","award":["IISR-2018-104317"],"award-info":[{"award-number":["IISR-2018-104317"]}]},{"name":"Investigator Initiated Research grant from Takeda Pharmaceuticals International AG, a member of the Takeda group of companies","award":["IIR-ITA-002522"],"award-info":[{"award-number":["IIR-ITA-002522"]}]},{"name":"Investigator Initiated Research grant from Takeda Pharmaceuticals International AG, a member of the Takeda group of companies","award":["#2020\/1"],"award-info":[{"award-number":["#2020\/1"]}]},{"name":"Investigator Initiated Research grant from Takeda Pharmaceuticals International AG, a member of the Takeda group of companies","award":["MEBIC # 18\/6\/2019"],"award-info":[{"award-number":["MEBIC # 18\/6\/2019"]}]},{"name":"local negotiation agreement \u2013 Frustaci","award":["IISR-2018-104317"],"award-info":[{"award-number":["IISR-2018-104317"]}]},{"name":"local negotiation agreement \u2013 Frustaci","award":["IIR-ITA-002522"],"award-info":[{"award-number":["IIR-ITA-002522"]}]},{"name":"local negotiation agreement \u2013 Frustaci","award":["#2020\/1"],"award-info":[{"award-number":["#2020\/1"]}]},{"name":"local negotiation agreement \u2013 Frustaci","award":["MEBIC # 18\/6\/2019"],"award-info":[{"award-number":["MEBIC # 18\/6\/2019"]}]},{"name":"Italian Health Ministry I.N.M.I. L. Spallanzani IR.C.C.S , IRCCS San Raffaele Roma","award":["IISR-2018-104317"],"award-info":[{"award-number":["IISR-2018-104317"]}]},{"name":"Italian Health Ministry I.N.M.I. L. Spallanzani IR.C.C.S , IRCCS San Raffaele Roma","award":["IIR-ITA-002522"],"award-info":[{"award-number":["IIR-ITA-002522"]}]},{"name":"Italian Health Ministry I.N.M.I. L. Spallanzani IR.C.C.S , IRCCS San Raffaele Roma","award":["#2020\/1"],"award-info":[{"award-number":["#2020\/1"]}]},{"name":"Italian Health Ministry I.N.M.I. L. Spallanzani IR.C.C.S , IRCCS San Raffaele Roma","award":["MEBIC # 18\/6\/2019"],"award-info":[{"award-number":["MEBIC # 18\/6\/2019"]}]},{"name":"Fondazione Roma","award":["IISR-2018-104317"],"award-info":[{"award-number":["IISR-2018-104317"]}]},{"name":"Fondazione Roma","award":["IIR-ITA-002522"],"award-info":[{"award-number":["IIR-ITA-002522"]}]},{"name":"Fondazione Roma","award":["#2020\/1"],"award-info":[{"award-number":["#2020\/1"]}]},{"name":"Fondazione Roma","award":["MEBIC # 18\/6\/2019"],"award-info":[{"award-number":["MEBIC # 18\/6\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Psoriasis (PS) is a common immune-mediated disease of the skin with possible extension to joints, aorta and eye. Myocardial inflammation has rarely been suggested. (2) Aims: Report of PS-related myocarditis. (3) Methods and Results: One hundred consecutive patients with PS were screened for cardiac involvement. Among them, five male patients (aged 56 \u00b1 9.5 years) with a moderate\u2013severe form of PS showed dilated cardiomyopathy (LVEF &lt; 35%) with normal coronary arteries and valves. They underwent a left-ventricular endomyocardial biopsy for evaluation of myocardial substrate. Endomyocardial samples were processed for histology and immunohistochemistry, including myocardial expression of Toll-Like Receptor 4 (TLR4) and interleukin-17A (IL-17A), which play a major role in PS pathogenesis. Real-time PCRs were carried out for cardiotropic viruses, and Western blot analysis was conducted for myocardial expression of IL-17A. Patients\u2019 sera were tested for anti-heart autoantibodies. Active lymphocytic myocarditis was revealed in all five patients, characterized by an absence of viral genomes with PCR, positive anti-heart autoantibodies, overexpression of TLR-4 and enhancement of IL-17-A during western blot analysis, showing a 2.48-fold increase in psoriatic myocarditis compared with no psoriatic myocarditis and a six-fold increase compared to myocardial controls. Treatment included combination of prednisone (1 mg\/kg daily for 4 weeks, tapered to 0.33 mg\/kg) and azathioprine (2 mg\/kg, daily) in 3 pts or secukinumab (SK, 150 mg\/weekly for 4 weeks followed by 150 mg\/monthly) in 2 pts for 6 months. LVEDD and LVEF improved in the first 3 pts (\u221214% and + 118%, respectively), while they completely recovered (LVEF &gt; 50%) in the last 2 pts on SK. (4) Conclusions: IL-17A-related myocarditis can occur in up to 5% of patients with PS. It manifests as progressive dilated cardiomyopathy. It may completely recover following SK administration.<\/jats:p>","DOI":"10.3390\/jcm12124010","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T02:00:45Z","timestamp":1686621645000},"page":"4010","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Interleukin-17A-Correlated Myocarditis in Patients with Psoriasis: Cardiac Recovery following Secukinumab Administration"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5748-0725","authenticated-orcid":false,"given":"Andrea","family":"Frustaci","sequence":"first","affiliation":[{"name":"IRCCS San Raffaele, Via di Val Cannuta, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4708-5120","authenticated-orcid":false,"given":"Nicola","family":"Galea","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Dominici","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Verardo","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Cardiology Lab, IRCCS L. Spallanzani, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Alfarano","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2237-9125","authenticated-orcid":false,"given":"Rossella","family":"Scialla","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Cardiology Lab, IRCCS L. Spallanzani, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Giovanni","family":"Richetta","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.14423\/SMJ.0000000000000603","article-title":"Psoriasis and Cardiomyopathy: A Review of the Literature","volume":"110","author":"Hashim","year":"2017","journal-title":"South Med. 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Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1046\/j.1365-2133.1998.02085.x","article-title":"Psoriatic arthritis associated with dilated cardiomyopathy and Takayasu\u2019s arteritis","volume":"138","author":"Fukuhara","year":"1998","journal-title":"Br. J. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/jdv.12123","article-title":"Relationship between parathyroid hormone and subclinical myocardial dysfunction in patients with severe psoriasis","volume":"28","author":"Zhao","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00403-015-1586-7","article-title":"Influence of psoriasis on circulatory system function assessed in echocardiography","volume":"307","author":"Milaniuk","year":"2015","journal-title":"Arch. Dermtol. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.17161\/kjm.vol1415225","article-title":"A Case of Autoimmune Myocarditis Treated with IL-17 Inhibition","volume":"14","author":"Jibbe","year":"2021","journal-title":"Kans. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12016-018-8702-3","article-title":"The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis","volume":"55","author":"Blauvelt","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1056\/NEJMoa1314258","article-title":"Secukinumab in Plaque Psoriasis\u2014Results of Two Phase 3 Trials","volume":"371","author":"Langley","year":"2014","journal-title":"N. Engl. J. 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Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1159\/000522167","article-title":"Psoriasis and Dry Eye Disease: A Systematic Review and Meta-Analysis","volume":"238","author":"Wu","year":"2022","journal-title":"Dermatology"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/12\/4010\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:53:33Z","timestamp":1760126013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/12\/4010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,12]]},"references-count":19,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["jcm12124010"],"URL":"https:\/\/doi.org\/10.3390\/jcm12124010","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,12]]}}}