{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:16:18Z","timestamp":1760148978745,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002509","name":"Keimyung University","doi-asserted-by":"publisher","award":["20220358"],"award-info":[{"award-number":["20220358"]}],"id":[{"id":"10.13039\/501100002509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Intravitreal bevacizumab (IVB), often injected during cataract surgery, is currently the main treatment for diabetic macular edema. This retrospective study aimed to compare the effectiveness of IVB injections alone and during cataract surgery in patients with diabetic macular edema. We examined 43 eyes in 40 patients who underwent cataract surgery with simultaneous IVB injections 3\u201312 months after IVB injections alone. Best-corrected visual acuity and central subfield macular thickness (CMT) were measured 1-month post-injection. The CMTs of the same eyes with IVB-only first and combined-treatment procedures later were 384 \u00b1 149 vs. 315 \u00b1 109 \u03bcm pretreatment (p = 0.0002), and after 1 month, they were 319 \u00b1 102 vs. 419 \u00b1 183 \u03bcm (p &lt; 0.0001). In the IVB-only procedure, 56.1% of eyes had CMT &lt; 300 \u03bcm 1 month after the injection compared to 32.5% after the combined treatment. Therefore, on average, when IVB was administered during cataract surgery, CMT increased, whereas after IVB injection alone, it effectively decreased. More prospective trials with large sample sizes are needed to evaluate the effectiveness of IVB injection performed simultaneously with cataract surgery.<\/jats:p>","DOI":"10.3390\/jcm12124060","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T03:18:46Z","timestamp":1686799126000},"page":"4060","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the Effectiveness of Intravitreal Bevacizumab Injections with and without Simultaneous Cataract Surgery in Diabetic Patients with Macular Edema"],"prefix":"10.3390","volume":"12","author":[{"given":"Jeeyoung","family":"Kwak","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-7942","authenticated-orcid":false,"given":"You Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-9607","authenticated-orcid":false,"given":"Kyung Tae","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1615-6651","authenticated-orcid":false,"given":"Yu Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3109\/08820539909069543","article-title":"Molecular mechanisms of vascular permeability in diabetic retinopathy","volume":"14","author":"Antonetti","year":"1999","journal-title":"Semin. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000455277","article-title":"Diabetic Macular Edema","volume":"58","author":"Bandello","year":"2017","journal-title":"Dev. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.ophtha.2008.08.023","article-title":"The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes","volume":"115","author":"Klein","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1097\/IAE.0000000000002221","article-title":"Phacoemulsification Cataract Surgery with Prophylactic Intravitreal Bevacizumab for Patients with Coexisting Diabetic Retinopathy: A Meta-Analysis","volume":"39","author":"Feng","year":"2019","journal-title":"Retina"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jcrs.2008.09.019","article-title":"Role of combined cataract surgery and intravitreal bevacizumab injection in preventing progression of diabetic retinopathy: Prospective randomized study","volume":"35","author":"Cheema","year":"2009","journal-title":"J. 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Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.ophtha.2009.03.003","article-title":"Development and progression of diabetic retinopathy 12 months after phacoemulsification cataract surgery","volume":"116","author":"Hong","year":"2009","journal-title":"Ophthalmology"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/12\/4060\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:55:23Z","timestamp":1760126123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/12\/4060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":11,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["jcm12124060"],"URL":"https:\/\/doi.org\/10.3390\/jcm12124060","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2023,6,15]]}}}