{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:18:50Z","timestamp":1789003130272,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background and Objectives: The present study aims to provide prenatal 2-dimensional ultrasonographic (2D-US) nomograms of the normal cerebellar area. Materials and Methods: This is a prospective cross-sectional analysis of 252 normal singleton pregnancies, ranging from 13 to 39 weeks of gestation. The operator performed measurements of the fetal cerebellar area in the transverse plane using 2D-US. The relationship between cerebellar area and gestational age (GA) was determined through regression equations. Results: A significant, strong positive correlation was investigated between the cerebellar area with GA (r-value = 0.89), and a positive correlation indicates that with increasing GA, the cerebellar area increased in all the participants of the study. Several 2D-US nomograms of the normal cerebellar area were provided, and an increase of 0.4% in the cerebellar area each week of GA was reported. Conclusions: We presented information on the typical dimensions of the fetal cerebellar area throughout gestation. In future studies, it could be evaluated how the cerebellar area changes with cerebellar abnormalities. It should be established if calculating the cerebellar area in addition to the routine transverse cerebellar diameter may help in discriminating posterior fossa anomalies or even help to identify anomalies that would otherwise remain undetected.<\/jats:p>","DOI":"10.3390\/jcm12124080","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T02:02:20Z","timestamp":1686880940000},"page":"4080","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fetal Cerebellar Area: Ultrasound Reference Ranges at 13\u201339 Weeks of Gestation"],"prefix":"10.3390","volume":"12","author":[{"given":"Luigi","family":"Manzo","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, Italy"},{"name":"Diagnostica Ecografica e Prenatale di A. Di Meglio, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, Italy"},{"name":"Diagnostica Ecografica e Prenatale di A. Di Meglio, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-0683","authenticated-orcid":false,"given":"Olimpia","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, Italy"},{"name":"Diagnostica Ecografica e Prenatale di A. Di Meglio, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Toscano","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, Italy"},{"name":"Diagnostica Ecografica e Prenatale di A. Di Meglio, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Di Lella","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, Italy"},{"name":"Diagnostica Ecografica e Prenatale di A. Di Meglio, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Lettieri","sequence":"additional","affiliation":[{"name":"Diagnostica Ecografica e Prenatale di A. Di Meglio, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Letizia","family":"Mazzarelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, Italy"},{"name":"Diagnostica Ecografica e Prenatale di A. Di Meglio, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giordana","family":"Sica","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Campania Luigi Vanvitelli, 81031 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Di Meglio","sequence":"additional","affiliation":[{"name":"Radiology Department, School of Medicine, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Di Meglio","sequence":"additional","affiliation":[{"name":"Pediatric Department, Bambino Ges\u00f9 Children\u2019s Research Hospital IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Ruffo","sequence":"additional","affiliation":[{"name":"Diagnostica Ecografica e Prenatale di A. Di Meglio, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Sica","sequence":"additional","affiliation":[{"name":"Diagnostica Ecografica e Prenatale di A. Di Meglio, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7910-0386","authenticated-orcid":false,"given":"Ferdinando Antonio","family":"Gulino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Garibaldi Nesima, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-0105","authenticated-orcid":false,"given":"Giosu\u00e8 Giordano","family":"Incognito","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical Surgical Specialties, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Tuscano","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical Surgical Specialties, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Giorno","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniello","family":"Di Meglio","sequence":"additional","affiliation":[{"name":"Diagnostica Ecografica e Prenatale di A. Di Meglio, 80133 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"ref_1","first-page":"176","article-title":"The volume of the cerebellum in the second semester of gestation","volume":"91","author":"Vulturar","year":"2018","journal-title":"Clujul Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0074-7742(08)60363-3","article-title":"Cerebellar Cognitive Affective Syndrome","volume":"41","author":"Schmahmann","year":"1997","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"E124","DOI":"10.1055\/s-0042-119952","article-title":"Fetal Cerebellar Vermis Circumference Measured by 2-Dimensional Ultrasound Scan: Reference Range, Feasibility and Reproducibility","volume":"2","author":"Spinelli","year":"2016","journal-title":"Ultrasound Int. 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