{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:15:16Z","timestamp":1760148916036,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The incidence of cardiac implantable electronic device (CIED)-related complications, as well as the prevalence of obesity, is rising worldwide. Transvenous laser lead extraction (LLE) has grown into a crucial therapeutic option for patients with CIED-related complications but the impact of obesity on LLE is not well understood. Methods and Results: All patients (n = 2524) from the GermAn Laser Lead Extraction RegistrY (GALLERY) were stratified into five groups according to their body mass index (BMI, &lt;18.5; 18.5\u201324.9; 25\u201329.9; 30\u201334.9; \u226535 kg\/m2). Patients with a BMI \u2265 35.0 kg\/m2 had the highest prevalence of arterial hypertension (84.2%, p &lt; 0.001), chronic kidney disease (36.8%, p = 0.020) and diabetes mellitus (51.1%, p &lt; 0.001). The rates for procedural minor (p = 0.684) and major complications (p = 0.498), as well as procedural success (p = 0.437), procedure-related (p = 0.533) and all-cause mortality (p = 0.333) were not different between groups. In obese patients (BMI \u2265 30 kg\/m2), lead age \u226510 years was identified as a predictor of procedural failure (OR: 2.99; 95% CI: 1.06\u20138.45; p = 0.038). Lead age \u226510 years (OR: 3.25; 95% CI: 1,31\u20138.10; p = 0.011) and abandoned leads (OR: 3.08; 95% CI: 1.03\u20139.22; p = 0.044) were predictors of procedural complications, while patient age \u226575 years seemed protective (OR: 0.27; 95% CI: 0.08\u20130.93; p = 0.039). Systemic infection was the only predictor for all-cause mortality (OR: 17.68; 95% CI: 4.03\u201377.49; p &lt; 0.001). Conclusions: LLE in obese patients is as safe and effective as in other weight classes, if performed in experienced high-volume centers. Systemic infection remains the main cause of in-hospital mortality in obese patients.<\/jats:p>","DOI":"10.3390\/jcm12124096","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T02:29:19Z","timestamp":1687141759000},"page":"4096","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Efficacy of Excimer Laser Powered Lead Extractions in Obese Patients: A GALLERY Subgroup Analysis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4243-7484","authenticated-orcid":false,"given":"Niklas","family":"Schenker","sequence":"first","affiliation":[{"name":"Department of Cardiology and Critical Care Medicine, Asklepios Klinik St. Georg, 20099 Hamburg, Germany"},{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg at the University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-7382","authenticated-orcid":false,"given":"Da-Un","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Critical Care Medicine, Asklepios Klinik St. Georg, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9832-0285","authenticated-orcid":false,"given":"Heiko","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Kerckhoff Klinik, 61231 Bad Nauheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-8954","authenticated-orcid":false,"given":"Lukas","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Critical Care Medicine, Asklepios Klinik St. Georg, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Osswald","sequence":"additional","affiliation":[{"name":"Division of Electrophysiological Surgery, Johanniter-Hospital Duisburg-Rheinhausen, 47228 Duisburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"B\u00e4rsch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Marien Krankenhaus, 57072 Siegen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"N\u00e4gele","sequence":"additional","affiliation":[{"name":"Department for Cardiac Insufficiency and Device Therapy, Albertinen-Hospital, 22457 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Knaut","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Heart Center Dresden, 01307 Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Reichenspurner","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart & Vascular Center Hamburg at the University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-7749","authenticated-orcid":false,"given":"Nele","family":"Gessler","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Critical Care Medicine, Asklepios Klinik St. Georg, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Willems","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Critical Care Medicine, Asklepios Klinik St. Georg, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Butter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center Brandenburg Bernau, 16321 Bernau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-166X","authenticated-orcid":false,"given":"Simon","family":"Pecha","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart & Vascular Center Hamburg at the University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Hakmi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Critical Care Medicine, Asklepios Klinik St. Georg, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20132013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s40273-014-0243-x","article-title":"The Epidemiology of Obesity: A Big Picture","volume":"33","author":"Hruby","year":"2016","journal-title":"Pharmacoeconomics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.26444\/aaem\/97226","article-title":"Assessment of epidemiological obesity among adults in EU 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