{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:37Z","timestamp":1787028637500,"version":"build-2736575974"},"reference-count":47,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Novo Nordisk postdoctoral fellowship run in partnership with Karolinska Institutet, Stockholm, Sweden"},{"name":"Karolinska Institutet Research Foundation"},{"name":"the Swedish Kidney Foundation (Njurfonden)"},{"name":"the Stiftelsen Stig och Gunborg Westman"},{"name":"the German Diabetes Association (DDG)"},{"name":"the EFSD Mentorship Programme supported by AstraZeneca"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Patients suffering from rheumatoid arthritis (RA) are repeatedly affected by oral diseases or complaints, including xerostomia, periodontitis and dental caries. The aim of this systematic review was the evaluation of caries prevalence and\/or incidence in patients with RA. Within this review, there is a systematic search of the literature based on PubMed, Web of Science and Scopus. Two independent researchers performed the search in February 2023. The search terms were \u201cdental caries\u201d AND \u201crheumatoid arthritis\u201d. Additionally, a manual search completed the review process. Studies on adult patients (age \u2265 18 years) only suffering from RA were included. Studies had to explicitly report on the prevalence or incidence of dental caries. The respective studies were checked regarding suitability and, if they were eligible, analyzed qualitatively. A quality appraisal was performed for all of the analyzed studies. A total of 336 studies were detected, of which 16 studies met the in- and exclusion criteria. The sample sizes of the clinical investigations ranged between 13 and 1337 participants. Twelve studies evaluated a healthy control group. In 8\/12 studies, a significant difference in the prevalence\/incidence of caries was found between RA patients and controls. The majority of the studies applied the decayed (DT), missing and filled teeth index (DMFT) for the diagnosis of caries. On average (mean value), 0.8 to 5.79 carious teeth per patient were reported across the studies. There was no information on the stadium, activity or location of caries (e.g., root caries) in any study. Quality appraisal revealed a moderate quality for most studies. In conclusion, caries prevalence was heterogeneous across studies, while a higher caries prevalence was repeatedly reported in RA patients against controls. Further research regarding dental caries in RA appears recommendable; multidisciplinary, patient-centered dental care for patients with RA should be fostered to improve patients\u2019 dental health status.<\/jats:p>","DOI":"10.3390\/jcm12124128","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T02:29:19Z","timestamp":1687141759000},"page":"4128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dental Caries in Adult Patients with Rheumatoid Arthritis\u2014A Systematic Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Deborah","family":"Kreher","sequence":"first","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bero","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-2368","authenticated-orcid":false,"given":"Dirk","family":"Ziebolz","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3716-4231","authenticated-orcid":false,"given":"Rainer","family":"Haak","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1683-9276","authenticated-orcid":false,"given":"Thomas","family":"Ebert","sequence":"additional","affiliation":[{"name":"Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6602-377X","authenticated-orcid":false,"given":"Gerhard","family":"Schmalz","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/0022034515573272","article-title":"Global bur-den of untreated caries: A systematic review and metaregression","volume":"94","author":"Kassebaum","year":"2015","journal-title":"J. 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