{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:35:01Z","timestamp":1790022901671,"version":"4.0.1"},"reference-count":115,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Placing antimicrobial treatments directly in periodontal pockets is an example of the local administration of antimicrobial drugs to treat periodontitis. This method of therapy is advantageous since the drug concentration after application far surpasses the minimum inhibitory concentration (MIC) and lasts for a number of weeks. As a result, numerous local drug delivery systems (LDDSs) utilizing various antibiotics or antiseptics have been created. There is constant effort to develop novel formulations for the localized administration of periodontitis treatments, some of which have failed to show any efficacy while others show promise. Thus, future research should focus on the way LDDSs can be personalized in order to optimize future clinical protocols in periodontal therapy.<\/jats:p>","DOI":"10.3390\/jcm12124137","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T01:59:30Z","timestamp":1687226370000},"page":"4137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Are Local Drug Delivery Systems a Challenge in Clinical Periodontology?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2312-6987","authenticated-orcid":false,"given":"Dana Gabriela","family":"Budal\u0103","sequence":"first","affiliation":[{"name":"Department of Implantology, Removable Prostheses, Dental Prostheses Technology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universit\u0103\u021bii Street, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-9672","authenticated-orcid":false,"given":"Ionut","family":"Luchian","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universit\u0103\u021bii Street, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Tatarciuc","sequence":"additional","affiliation":[{"name":"Department of Implantology, Removable Prostheses, Dental Prostheses Technology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universit\u0103\u021bii Street, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-399X","authenticated-orcid":false,"given":"Oana","family":"Butnaru","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina Oana","family":"Armencia","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oral Health, Faculty of Dental Medicine, \u201cGrigore T. 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