{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:09:09Z","timestamp":1790399349234,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministry of Education and Science","doi-asserted-by":"publisher","award":["SUBZ.E060.23.037"],"award-info":[{"award-number":["SUBZ.E060.23.037"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: The total number of confirmed cases of COVID-19 caused by the SARS-CoV-2 virus infection is over 621 million in the world. In approximately 63% of cases, the patient still experiences persistent symptoms 30 days after the onset of symptoms or hospitalisation, and 45.9% of patients have experienced or will experience symptoms for at least three months. Despite the prevalence of chronic symptoms and pathological changes that may affect gait and functional mobility in people with a history of COVID-19, there are few publications investigating the impact of these abnormalities. This study aims to determine the long-term effects of COVID-19 on gait and the Timed-Up and Go Task. Material and Methods: A total of 30 individuals took part in the experiment. The subjects in the study group were infected with the COVID-19 virus and required hospital treatment. Prior to the study, the subjects had no chronic diseases or other conditions affecting the musculoskeletal system. The non-infected by COVID-19 group was a healthy population with no history of COVID-19 disease. The study used the inertial system wireless motion analysis system based on 15 inertial sensors (inertial measurement units, IMUs). IMU sensors were placed on the following body segments: head, sternum, middle and lower spine, shoulder, arm, forearm, hand, shank, for the left and right limb. Movement task reports generated from the recording were created using myoRESEARCH 3.10. The subjects in the study group were asked to perform a movement task test\u2014the Timed-Up and Go Test (TUG): sit-to-stand, walk (3 m) without change in direction, walk termination, and stand-to-sit. Results: It took 46% longer for those infected by COVID-19 (participants) to complete the entire movement task compared to those in the not-infected by COVID-19 group. Sit-to-Stand Time [s] was greater in the infected by COVID-19 group and was 2.1 \u00b1 0.7. Mean Walking Speed [m\/s] was lower than in the not-infected by COVID-19 group and was 0.26 \u00b1 0.07. Walking cadence [steps\/min] was lower and was 21.2 \u00b1 1.2. Infected by COVID-19 participants achieved a smaller anterior pelvic tilt angle (p &lt; 0.001) and a smaller hip flexion angle (p = 0.025), with an increase in knee (p &lt; 0.001) and ankle (p &lt; 0.001) flexion angles. Conclusions: Individuals in the infected by COVID-19 group present changes in the ranges of motion and the time to complete the TUG task, despite the fact that at least eight weeks passed after hospital discharge.<\/jats:p>","DOI":"10.3390\/jcm12134184","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T02:09:17Z","timestamp":1687399757000},"page":"4184","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of COVID-19 on Musculoskeletal Performance in Gait and the Timed-Up and Go Test"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4796-630X","authenticated-orcid":false,"given":"Mateusz","family":"Kowal","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, Wroclaw Medical University, T. Cha\u0142ubi\u0144skiego 3, 50-556 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9506-698X","authenticated-orcid":false,"given":"Ewa","family":"Morgiel","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6109-7510","authenticated-orcid":false,"given":"S\u0142awomir","family":"Winiarski","sequence":"additional","affiliation":[{"name":"Biomechanics Department, Wroclaw University of Health and Sport Sciences, Paderewskiego 35, 51-612 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-5385","authenticated-orcid":false,"given":"Ewa","family":"Gieysztor","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Wroclaw Medical University, T. Cha\u0142ubi\u0144skiego 3, 50-556 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Madej","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Madziarski","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Internal Medicine, University Hospital, Borowska Street 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Wedel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., New York, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Proc","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Internal Medicine, University Hospital, Borowska Street 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-3691","authenticated-orcid":false,"given":"Katarzyna","family":"Madziarska","sequence":"additional","affiliation":[{"name":"Clinical Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Wiland","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Paprocka-Borowicz","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Wroclaw Medical University, T. Cha\u0142ubi\u0144skiego 3, 50-556 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2023, May 12). Coronavirus Disease (COVID-19) Pandemic. Available online: www.who.int\/emergencies\/diseases\/novel-coronavirus-2019."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"106197","DOI":"10.1016\/j.rmed.2020.106197","article-title":"Follow up of patients with severe coronavirus disease 2019 (COVID-19): Pulmonary and extrapulmonary disease sequelae","volume":"174","author":"Daher","year":"2020","journal-title":"Respir. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41591-021-01292-y","article-title":"Attributes and predictors of long COVID","volume":"27","author":"Sudre","year":"2021","journal-title":"Nat. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejim.2021.06.009","article-title":"Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis","volume":"92","author":"Florencio","year":"2021","journal-title":"Eur. J. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"E102","DOI":"10.1016\/S1473-3099(21)00703-9","article-title":"Definition WHOCC. A clinical case definition of post-COVID-19 condition by a Delphi consensus","volume":"22","author":"Soriano","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/01410768211032850","article-title":"Symptoms, complications and management of long COVID: A review","volume":"114","author":"Aiyegbusi","year":"2021","journal-title":"J. R. Soc. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1136\/bjsports-2020-102596","article-title":"The Stanford Hall consensus statement for post-COVID-19 rehabilitation","volume":"54","author":"Senaratne","year":"2020","journal-title":"Br. J. Sport. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s00256-021-03734-7","article-title":"Musculoskeletal involvement of COVID-19: Review of imaging","volume":"50","author":"Ramani","year":"2021","journal-title":"Skelet. Radiol."},{"key":"ref_9","first-page":"S93","article-title":"Management of musculoskeletal consequences in persons with post-COVID-19 syndrome","volume":"34","author":"Kucudiaeresi","year":"2022","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2106\/JBJS.20.00847","article-title":"Musculoskeletal Consequences of COVID-19","volume":"102","author":"Disser","year":"2020","journal-title":"J. Bone Jt. Surg. -Am. Vol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1159\/000517719","article-title":"Musculoskeletal Consequences from COVID-19 and the Importance of Pulmonary Rehabilitation Program","volume":"100","author":"Rosa","year":"2021","journal-title":"Respiration"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S2213-2600(21)00125-9","article-title":"Confronting COVID-19-associated cough and the post-COVID syndrome: Role of viral neurotropism, neuroinflammation, and neuroimmune responses","volume":"9","author":"Song","year":"2021","journal-title":"Lancet Respir. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"(2021). Long COVID: Understanding the neurological effects. Lancet Neurol., 20, 247.","DOI":"10.1016\/S1474-4422(21)00059-4"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13195-020-00640-3","article-title":"Immediate and long-term consequences of COVID-19 infections for the development of neurological disease","volume":"12","author":"Heneka","year":"2020","journal-title":"Alzheimers Res. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.apmr.2020.12.021","article-title":"Predictors of Low Physical Function in Patients With COVID-19 With Acute Respiratory Failure Admitted to a Subacute Unit","volume":"102","author":"Paneroni","year":"2021","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/jmv.26368","article-title":"Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation","volume":"93","author":"Halpin","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jama.2020.12603","article-title":"Persistent Symptoms in Patients After Acute COVID-19","volume":"324","author":"Carfi","year":"2020","journal-title":"Jama J. Am. Med. Assoc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.gaitpost.2021.11.002","article-title":"Recreational runners who recovered from COVID-19 show different running kinetics and muscle activities compared with healthy controls","volume":"91","author":"Jafarnezhadgero","year":"2022","journal-title":"Gait Posture"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"111098","DOI":"10.1016\/j.jbiomech.2022.111098","article-title":"Individuals with a COVID-19 history exhibit asymmetric gait patterns despite full recovery","volume":"137","author":"Keklicek","year":"2022","journal-title":"J. Biomech."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1007\/s10072-021-05341-9","article-title":"Symptoms of gait and coordination impairment in a patient with COVID-19 interstitial pneumonia","volume":"42","author":"Pistoia","year":"2021","journal-title":"Neurol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e12050","DOI":"10.1016\/j.heliyon.2022.e12050","article-title":"Adopted walking condition for computational simulation approach on bearing of hip joint prosthesis: Review over the past 30 years","volume":"8","author":"Jamari","year":"2022","journal-title":"Heliyon"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"703982","DOI":"10.3389\/fspor.2021.703982","article-title":"Head and Body Dyskinesia During Gait in Tactical Athletes With Vestibular Deficit Following Concussion","volume":"3","author":"Fraser","year":"2021","journal-title":"Front. Sport. Act. Living"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Kumar, D., Villarreal, D.J., and Meuret, A.E. (2021). Walking on the bright side: Associations between affect, depression, and gait. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0260893"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jphys.2020.03.011","article-title":"Physiotherapy management for COVID-19 in the acute hospital setting: Clinical practice recommendations","volume":"66","author":"Thomas","year":"2020","journal-title":"J. Physiother."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Park, S., and Yoon, S. (2021). Validity Evaluation of an Inertial Measurement Unit (IMU) in Gait Analysis Using Statistical Parametric Mapping (SPM). Sensors, 21.","DOI":"10.3390\/s21113667"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1109\/TNSRE.2018.2875738","article-title":"Automatic Timed Up-and-Go Sub-Task Segmentation for Parkinson\u2019s Disease Patients Using Video-Based Activity Classification","volume":"26","author":"Li","year":"2018","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s11556-020-00252-8","article-title":"Cultural adaptation and validation of the Polish version of the physical activity scale for older people living in a community: A cross-sectional study","volume":"17","author":"Woloszyn","year":"2020","journal-title":"Eur. Rev. Aging Phys. Act."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/ptj\/70.10.638","article-title":"Whole-Body Movements during Rising to Standing from Sitting","volume":"70","author":"Schenkman","year":"1990","journal-title":"Phys. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0021-9290(01)00222-6","article-title":"ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion-part 1: Ankle, hip, and spine","volume":"35","author":"Wu","year":"2002","journal-title":"J. Biomech."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.jbiomech.2004.05.042","article-title":"ISB recommendation on definitions of joint coordinate systems of various joints for the reporting of human joint motion-Part II: Shoulder, elbow, wrist and hand","volume":"38","author":"Wu","year":"2005","journal-title":"J. Biomech."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.clinbiomech.2008.12.009","article-title":"A framework for the definition of standardized protocols for measuring upper-extremity kinematics","volume":"24","author":"Kontaxis","year":"2009","journal-title":"Clin. Biomech."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5555874","DOI":"10.1155\/2021\/5555874","article-title":"The Application of Statistical Parametric Mapping to Evaluate Differences in Topspin Backhand between Chinese and Polish Female Table Tennis Players","volume":"2021","author":"Bankosz","year":"2021","journal-title":"Appl. Bionics Biomech."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Bankosz, Z., and Winiarski, S. (2020). Statistical Parametric Mapping Reveals Subtle Gender Differences in Angular Movements in Table Tennis Topspin Backhand. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17196996"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Saito, Y., Ishida, T., Kataoka, Y., Takeda, R., Tadano, S., Suzuki, T., Nakamura, K., Nakata, A., Osuka, S., and Yamada, S. (2022). Evaluation of gait characteristics in subjects with locomotive syndrome using wearable gait sensors. BMC Musculoskelet. Disord., 23.","DOI":"10.1186\/s12891-022-05411-9"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jbiomech.2018.12.023","article-title":"Assessment of the measurement accuracy of inertial sensors during different tasks of daily living","volume":"84","author":"Mundt","year":"2019","journal-title":"J. Biomech."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Bankosz, Z., Winiarski, S., and Lanzoni, I.M. (2020). Gender Differences in Kinematic Parameters of Topspin Forehand and Backhand in Table Tennis. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17165742"},{"key":"ref_37","first-page":"9","article-title":"Three-dimensional human gait pattern-reference data for normal men","volume":"14","author":"Pietraszewski","year":"2012","journal-title":"Acta Bioeng. Biomech.\/Wroc. Univ. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9232430","DOI":"10.1155\/2019\/9232430","article-title":"Three-Dimensional Human Gait Pattern: Reference Data for Young, Active Women Walking with Low, Preferred, and High Speeds","volume":"2019","author":"Winiarski","year":"2019","journal-title":"Biomed Res. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/ptj\/80.9.896","article-title":"Predicting the probability for falls in community-dwelling older adults using the Timed Up & Go Test","volume":"80","author":"Brauer","year":"2000","journal-title":"Phys. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"355","DOI":"10.15585\/mmwr.mm7010e4","article-title":"Body Mass Index and Risk for COVID-19-Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death-United States, March-December 2020","volume":"70","author":"Kompaniyets","year":"2021","journal-title":"Mmwr-Morb. Mortal. Wkly. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"886","DOI":"10.7326\/L21-0063","article-title":"Obesity and Mortality Among Patients Diagnosed With COVID-19","volume":"174","author":"Kollias","year":"2021","journal-title":"Ann. Intern. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1007\/s11739-022-03039-0","article-title":"Relationship between the severity of persistent symptoms, physical fitness, and cardiopulmonary function in post-COVID-19 condition. A population-based analysis","volume":"17","author":"Tufano","year":"2022","journal-title":"Intern. Emerg. Med."},{"key":"ref_43","first-page":"1383","article-title":"Mid-term impact of mild-moderate COVID-19 on cardiorespiratory fitness in elite athletes","volume":"62","author":"Anastasio","year":"2022","journal-title":"J. Sport. Med. Phys. Fit."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Jamari, J., Ammarullah, M.I., Saad, A.P.M., Syahrom, A., Uddin, M., van der Heide, E., and Basri, H. (2021). The Effect of Bottom Profile Dimples on the Femoral Head on Wear in Metal-on-Metal Total Hip Arthroplasty. J. Funct. Biomater., 12.","DOI":"10.3390\/jfb12020038"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ammarullah, M.I., Hartono, R., Supriyono, T., Santoso, G., Sugiharto, S., and Permana, M.S. (2023). Polycrystalline Diamond as a Potential Material for the Hard-on-Hard Bearing of Total Hip Prosthesis: Von Mises Stress Analysis. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030951"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Grove, K., Edgar, D.W., Chih, H., Harrold, M., Natarajan, V., Mohd, S., Hurn, E., and Cavalheri, V. (2022). Greater In-Hospital Care and Early Rehabilitation Needs in People with COVID-19 Compared with Those without COVID-19. J. Clin. Med., 11.","DOI":"10.3390\/jcm11133602"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jcsm.12896","article-title":"Skeletal muscle alterations in patients with acute COVID-19 and post-acute sequelae of COVID-19","volume":"13","author":"Soares","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/PHM.0000000000001641","article-title":"Muscle Strength and Physical Performance in Patients Without Previous Disabilities Recovering From COVID-19 Pneumonia","volume":"100","author":"Paneroni","year":"2021","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Floreani, M., Rejc, E., Taboga, P., Ganzini, A., Pi\u0161ot, R., \u0160imuni\u010d, B., Biolo, G., Reggiani, C., Passaro, A., and Narici, M. (2018). Effects of 14 days of bed rest and following physical training on metabolic cost, mechanical work, and efficiency during walking in older and young healthy males. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194291"},{"key":"ref_50","first-page":"31","article-title":"Tresca stress study of CoCrMo-on-CoCrMo bearings based on body mass index using 2D computational model","volume":"33","author":"Ammarullah","year":"2022","journal-title":"J. Tribol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/13\/4184\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:57:51Z","timestamp":1760126271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/13\/4184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":50,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["jcm12134184"],"URL":"https:\/\/doi.org\/10.3390\/jcm12134184","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,21]]}}}