{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:37:35Z","timestamp":1783996655570,"version":"3.55.0"},"reference-count":32,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study describes the characteristics of women who contacted an active program performing uterus transplantation (UTx) in the US, expressing interest in becoming a uterus transplant recipient or a living donor. Basic demographic and self-reported clinical information was collected from women who contacted any of the three US UTx programs from 2015 to July 2022. The three centers received 5194 inquiries about becoming a UTx recipient during the study timeframe. Among those reporting a cause of infertility, almost all of the reports (4066\/4331, 94%) were absence of a uterus, either congenitally (794\/4066, 20%) or secondary to hysterectomy (3272\/4066, 80%). The mean age was 34 years, and 49% (2545\/5194) had at least one child at the time of application. The two centers using living donors received 2217 inquiries about becoming living donors. The mean age was 34 years, and 60% (1330\/2217) had given birth to \u22651 child. While most of the UTx clinical trial evidence has focused on young women with congenital absence of the uterus, these results show interest from a much broader patient population in terms of age, cause of infertility, and parity. These results raise questions about whether and to what extent the indications and eligibility criteria for UTx should be expanded as the procedure transitions from the experimental phase to being offered as a clinical treatment.<\/jats:p>","DOI":"10.3390\/jcm12134201","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T02:09:17Z","timestamp":1687399757000},"page":"4201","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8572-3811","authenticated-orcid":false,"given":"Liza","family":"Johannesson","sequence":"first","affiliation":[{"name":"Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USA"},{"name":"Department of Obstetrics and Gynecology, Baylor University Medical Center, Dallas, TX 75246, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Testa","sequence":"additional","affiliation":[{"name":"Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menas M.","family":"Beshara","sequence":"additional","affiliation":[{"name":"TX A&M College of Medicine, Texas A&M University, Dallas, TX 75231, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briget","family":"da Graca","sequence":"additional","affiliation":[{"name":"Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Northwestern University, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Quintini","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawar","family":"Latif","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH 44103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott G.","family":"Richards","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology and Women\u2019s Health Institute, Cleveland Clinic, Cleveland, OH 44103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1001\/jamasurg.2022.2612","article-title":"The first 5 years of uterus transplant in the US: A report from the United States Uterus Transplant Consortium","volume":"157","author":"Johannesson","year":"2022","journal-title":"JAMA Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/ajt.14737","article-title":"First live birth after uterus transplantation in the United States","volume":"18","author":"Testa","year":"2018","journal-title":"Am. J. Transplant."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/TP.0000000000004286","article-title":"Registry of the International Society of Uterus Transplantation: First report","volume":"107","author":"Tullius","year":"2023","journal-title":"Transplantation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ajog.2016.11.1028","article-title":"Characterizing women with interest in uterine transplant clinical trials in the United States: Who seeks information on this experimental treatment?","volume":"216","author":"Arian","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Carbonnel, M., Revaux, A., Menzhulina, E., Karpel, L., Snanoudj, R., Le Guen, M., De Ziegler, D., and Ayoubi, J.M. (2020). Uterus transplantation with live donors: Screening candidates in one French center. J. Clin. Med., 9.","DOI":"10.3390\/jcm9062001"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejogrb.2016.08.027","article-title":"Uterus transplantation in France: For which patients?","volume":"205","author":"Huet","year":"2016","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"331.e1","DOI":"10.1016\/j.ajog.2017.11.594","article-title":"Living uterus donation and transplantation: Experience of interest and screening in a single center in the United States","volume":"218","author":"Johannesson","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.fertnstert.2018.09.010","article-title":"Screening and evaluation of potential recipients and donors for living donor uterus transplantation: Results from a single-center observational study","volume":"111","author":"Taran","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Johannesson, L., Testa, G., da Graca, B., and Wall, A. (2023). How surgical research gave birth to a new clinical surgical field: A viewpoint from the Dallas Uterus Transplant Study. Eur. Surg. Res., 158\u2013168.","DOI":"10.1159\/000528989"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/15269248211046027","article-title":"Motivations and psychological characteristics of nondirected uterus donors from the Dallas UtErus Transplant Study","volume":"31","author":"Warren","year":"2021","journal-title":"Prog. Transplant."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Dion, L., Santin, G., Nyangoh Timoh, K., Boudjema, K., Jacquot Thierry, L., Gauthier, T., Carbonnel, M., Ayoubi, J.M., Kerbaul, F., and Lavoue, V. (2022). Procurement of uterus in a deceased donor multi-organ donation national program in France: A scarce resource for uterus transplantation?. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030730"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1097\/TP.0000000000002830","article-title":"Limited availability of deceased uterus donors: A transatlantic perspective","volume":"103","author":"Kristek","year":"2019","journal-title":"Transplantation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014A metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap Consortium: Building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J. Biomed. Inform."},{"key":"ref_15","unstructured":"Sifferlin, A. (2023, May 23). First U.S. baby born after a uterus transplant. Available online: https:\/\/time.com\/5044565\/exclusive-first-u-s-baby-born-after-a-uterus-transplant\/."},{"key":"ref_16","unstructured":"Park, M. (2023, March 03). Baby is first to be born in US after uterus transplant, hospital says. Available online: https:\/\/www.cnn.com\/2017\/12\/04\/health\/uterus-transplant-us-baby-birth\/index.html."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.fertnstert.2014.02.024","article-title":"First clinical uterus transplantation trial: A six-month report","volume":"101","author":"Johannesson","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Frisch, E.H., Falcone, T., Flyckt, R.L., Tzakis, A.G., Kodish, E., and Richards, E.G. (2022). Uterus transplantation: Revisiting the question of deceased donors versus living donors for organ procurement. J. Clin. Med., 11.","DOI":"10.3390\/jcm11154516"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/15265161.2018.1478018","article-title":"Uterus transplantation: The ethics of using deceased versus living donors","volume":"18","author":"Bruno","year":"2018","journal-title":"Am. J. Bioeth."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.fertnstert.2013.05.026","article-title":"Ethical considerations in the era of the uterine transplant: An update of the Montreal criteria for the ethical feasibility of uterine transplantation","volume":"100","author":"Lefkowitz","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/15265161.2018.1478026","article-title":"Living donation, listing, and prioritization in uterus transplantation","volume":"18","author":"Wall","year":"2018","journal-title":"Am. J. Bioeth."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1017\/S0963180115000687","article-title":"The ethics of allocating uterine transplants","volume":"25","author":"Bayefsky","year":"2016","journal-title":"Camb. Q. Healthc. Ethics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/15265161.2018.1478025","article-title":"Allocating uterus transplants\u2014Who gets to be a gestational mother?","volume":"18","author":"Rogers","year":"2018","journal-title":"Am. J. Bioeth."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1432-2277.2012.01438.x","article-title":"The Montreal criteria for the ethical feasibility of uterine transplantation","volume":"25","author":"Lefkowitz","year":"2012","journal-title":"Transpl. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1093\/humrep\/deaa143","article-title":"Uterus transplantation: Joys and frustrations of becoming a \u2018complete\u2019 woman\u2014A qualitative study regarding self-image in the 5-year period after transplantation","volume":"35","author":"Enskog","year":"2020","journal-title":"Hum. Reprod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/1471-0528.17052","article-title":"The journey from infertility to uterus transplantation: A qualitative study of the perspectives of participants in the Dallas Uterus Transplant Study","volume":"129","author":"Wall","year":"2022","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.mayocpiqo.2019.11.001","article-title":"Provider knowledge and support of uterus transplantation: Surveying multidisciplinary team members","volume":"4","author":"Riggan","year":"2020","journal-title":"Mayo Clin. Proc. Innov. Qual. Outcomes"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.jmig.2018.02.013","article-title":"Uterine transplantation: A survey of perceptions and attitudes of American reproductive endocrinologists and gynecologic surgeons","volume":"25","author":"Bortoletto","year":"2018","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_29","unstructured":"Baylor Scott & White Health (2023, January 20). Uterus Transplant Donor Eligibility. Available online: https:\/\/www.bswhealth.com\/treatments-and-procedures\/uterus-transplant."},{"key":"ref_30","unstructured":"PennMedicine (2023, January 20). Frequently Asked Questions and Answers about Uterus Transplant. Available online: https:\/\/www.pennmedicine.org\/for-patients-and-visitors\/find-a-program-or-service\/transplant-institute\/uterus-transplant\/faqs-about-uterus-transplant#can-women-donate-their-uterus."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/00001888-199409000-00002","article-title":"Historical background of clinical trials involving women and minorities","volume":"69","author":"McCarthy","year":"1994","journal-title":"Acad. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.cpcardiol.2018.11.002","article-title":"Increasing diversity in clinical trials: Overcoming critical barriers","volume":"44","author":"Clark","year":"2019","journal-title":"Curr. Probl. Cardiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/13\/4201\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:58:13Z","timestamp":1760126293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/13\/4201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":32,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["jcm12134201"],"URL":"https:\/\/doi.org\/10.3390\/jcm12134201","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,21]]}}}