{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:17:19Z","timestamp":1760149039931,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education","award":["NRF-2021R1A2C2093617"],"award-info":[{"award-number":["NRF-2021R1A2C2093617"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Superficial and deep macular vessel density (VD) is decreased in eyes with glaucoma. Superficial VD comprises both the retinal nerve fiber layer (RNFL) and ganglion cell\/inner plexiform layer (GC\/IPL), and various terms have been used previously to describe the layers of macular VD. In our study, we readjusted the macular segmentation. We obtained RNFL and GC\/IPL VDs separately to evaluate VD changes of axon versus soma\/dendrite of the retinal ganglion cells (RGCs) in detail. We included 66 eyes of normal tension glaucoma patients with inferior localized RNFL defects solely impacting the inferior hemiretina. Macular VD was measured as RNFL VD and GC\/IPL VD. VD ratio was calculated by dividing the VD from the affected hemiretina by the VD from the unaffected hemiretina. RNFL VD ratio was related to RNFL and GC\/IPL thicknesses (p = 0.005, p = 0.001), whereas GC\/IPL VD ratio was not (p = 0.596, p = 0.783). A lower GC\/IPL VD ratio was associated with lower RNFL VD (p = 0.017) and systemic hypertension (p = 0.03) in multivariate analysis. Patients with a reduced GC\/IPL VD ratio were more prone to poor visual field defects (p = 0.022) and paracentral scotoma (p = 0.046) and more likely to be on treatment for systemic hypertension (p = 0.024). Therefore, glaucoma patients on systemic hypertension treatment and reduced GC\/IPL VD require cautious management.<\/jats:p>","DOI":"10.3390\/jcm12134221","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T02:34:07Z","timestamp":1687487647000},"page":"4221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated with Vascular Changes at the Level of Retinal Ganglion Cell Axon versus Soma\/Dendrite in Glaucoma Patients"],"prefix":"10.3390","volume":"12","author":[{"given":"Si-Eun","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Jong","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan-Kee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-5332","authenticated-orcid":false,"given":"Hae-Young Lopilly","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"ref_1","first-page":"640","article-title":"Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head","volume":"16","author":"Quigley","year":"1977","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1001\/archopht.1981.03930010635009","article-title":"Optic nerve damage in human glaucoma: II. The site of injury and susceptibility to damage","volume":"99","author":"Quigley","year":"1981","journal-title":"Arch. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100881","DOI":"10.1016\/j.preteyeres.2020.100881","article-title":"Retinal energy metabolism in health and glaucoma","volume":"81","author":"Casson","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_4","first-page":"OP240","article-title":"Anatomy and physiology of the optic nerve head","volume":"78","author":"Hayreh","year":"1974","journal-title":"Trans. Am. Acad. Ophthalmol. Otolaryngol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0039-6257(87)90072-5","article-title":"Anatomy of the optic nerve head and glaucomatous optic neuropathy","volume":"32","author":"Radius","year":"1987","journal-title":"Surv. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1097\/00061198-200110001-00007","article-title":"The anatomy and pathophysiology of the optic nerve head in glaucoma","volume":"10","author":"Burgoyne","year":"2001","journal-title":"J. Glaucoma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.preteyeres.2005.04.004","article-title":"Glaucoma: Thinking in new ways\u2014A role for autonomous axonal self-destruction and other compartmentalised processes?","volume":"24","author":"Whitmore","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.preteyeres.2013.07.001","article-title":"Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability","volume":"36","author":"Yu","year":"2013","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_9","first-page":"1593","article-title":"Selective effects of experimental glaucoma on axonal transport by retinal ganglion cells to the dorsal lateral geniculate nucleus","volume":"32","author":"Dandona","year":"1991","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jeon, S.J., Jung, K.I., Park, C.K., and Park, H.-Y.L. (2022). Macular Blood Flow and Pattern Electroretinogram in Normal Tension Glaucoma. J. Clin. Med., 11.","DOI":"10.3390\/jcm11071790"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1097\/IJG.0000000000001860","article-title":"Superficial and deep macula vessel density in healthy, glaucoma suspect, and glaucoma eyes","volume":"30","author":"Manalastas","year":"2021","journal-title":"J. Glaucoma"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"16813","DOI":"10.1038\/s41598-019-53354-4","article-title":"Association of Retinal Blood Flow with Progression of Visual Field in Glaucoma","volume":"9","author":"Jeon","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1038\/s41598-018-34417-4","article-title":"Effect of Macular Vascular Density on Central Visual Function and Macular Structure in Glaucoma Patients","volume":"8","author":"Jeon","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/IJG.0000000000002069","article-title":"Peripapillary and Macular Vascular Density in Patients With Preperimetric and Early Primary Open Angle Glaucoma","volume":"31","author":"Oba","year":"2022","journal-title":"J. Glaucoma"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10792-020-01564-5","article-title":"Comparison of vessel density in macular and peripapillary regions between primary open-angle glaucoma and pseudoexfoliation glaucoma using OCTA","volume":"41","author":"Subasi","year":"2021","journal-title":"Int. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/02713683.2019.1676912","article-title":"Quantitative analysis of microvasculature in macular and peripapillary regions in early primary open-angle glaucoma","volume":"45","author":"Lu","year":"2020","journal-title":"Curr. Eye Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"744","DOI":"10.18240\/ijo.2020.05.08","article-title":"Optical coherence tomography angiography of the peripapillary region and macula in normal, primary open angle glaucoma, pseudoexfoliation glaucoma and ocular hypertension eyes","volume":"13","author":"Tekeli","year":"2020","journal-title":"Int. J. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00417-021-05321-x","article-title":"Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma","volume":"260","author":"Cornelius","year":"2022","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s00417-018-3965-1","article-title":"OCTA vessel density changes in the macular zone in glaucomatous eyes","volume":"256","author":"Lommatzsch","year":"2018","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1136\/bjophthalmol-2016-309816","article-title":"Swept-source OCT angiography imaging of the macular capillary network in glaucoma","volume":"102","author":"Akil","year":"2018","journal-title":"Br. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"102671","DOI":"10.1016\/j.amsu.2021.102671","article-title":"Optical coherence tomography angiography vessel density parameters in primary open-angle glaucoma","volume":"69","author":"Khayrallah","year":"2021","journal-title":"Ann. Med. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1167\/iovs.62.15.17","article-title":"Microvasculature Recovery Detected Using Optical Coherence Tomography Angiography and the Rate of Visual Field Progression After Glaucoma Surgery","volume":"62","author":"Park","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"18503","DOI":"10.1038\/s41598-019-54882-9","article-title":"Association between peripapillary scleral deformation and choroidal microvascular circulation in glaucoma","volume":"9","author":"Shin","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1001\/jamaophthalmol.2019.0422","article-title":"Association Between Parapapillary Choroidal Vessel Density Measured With Optical Coherence Tomography Angiography and Future Visual Field Progression in Patients With Glaucoma","volume":"137","author":"Park","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.ophtha.2018.01.016","article-title":"Choroidal microvasculature dropout is associated with progressive retinal nerve fiber layer thinning in glaucoma with disc hemorrhage","volume":"125","author":"Park","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1038\/s41598-022-09162-4","article-title":"Association of choroidal blood flow with autonomic dysfunction in patients with normal tension glaucoma","volume":"12","author":"Shin","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"10173","DOI":"10.1038\/s41598-022-13781-2","article-title":"Comparison between frequency-doubling technology perimetry and standard automated perimetry in early glaucoma","volume":"12","author":"Kim","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.ophtha.2018.05.006","article-title":"Macular and optic nerve head vessel density and progressive retinal nerve fiber layer loss in glaucoma","volume":"125","author":"Moghimi","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ophtha.2017.01.004","article-title":"Peripapillary and macular vessel density in patients with glaucoma and single-hemifield visual field defect","volume":"124","author":"Yarmohammadi","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ajo.2017.07.011","article-title":"Progressive macula vessel density loss in primary open-angle glaucoma: A longitudinal study","volume":"182","author":"Shoji","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"42201","DOI":"10.1038\/srep42201","article-title":"Detailed vascular anatomy of the human retina by projection-resolved optical coherence tomography angiography","volume":"7","author":"Campbell","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/IJG.0000000000000964","article-title":"Optical coherence tomography angiography macular vascular density measurements and the central 10-2 visual field in glaucoma","volume":"27","author":"Penteado","year":"2018","journal-title":"J. Glaucoma"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1523\/JNEUROSCI.3430-11.2012","article-title":"The energetics of CNS white matter","volume":"32","author":"Harris","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1350-9462(00)00027-6","article-title":"Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease","volume":"20","author":"Yu","year":"2001","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S0161-6420(03)00075-7","article-title":"Hypertension, diabetes, and longitudinal changes in intraocular pressure","volume":"110","author":"Hennis","year":"2003","journal-title":"Ophthalmology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00061198-200408000-00010","article-title":"Open-angle glaucoma and systemic hypertension: The blue mountains eye study","volume":"13","author":"Mitchell","year":"2004","journal-title":"J. Glaucoma"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1442-9071.1997.tb01295.x","article-title":"Optic disc haemorrhages and vascular abnormalities in a glaucoma population","volume":"25","author":"Barry","year":"1997","journal-title":"Aust. N. Z. J. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/13\/4221\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:58:54Z","timestamp":1760126334000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/13\/4221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,22]]},"references-count":37,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["jcm12134221"],"URL":"https:\/\/doi.org\/10.3390\/jcm12134221","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2023,6,22]]}}}