{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:24:12Z","timestamp":1793906652434,"version":"4.8.0"},"reference-count":37,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003756","name":"Helsinki University Hospital","doi-asserted-by":"publisher","award":["HUS\/441\/2022"],"award-info":[{"award-number":["HUS\/441\/2022"]}],"id":[{"id":"10.13039\/501100003756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Research on the use of psychotropic drugs in people with alcohol-related neurocognitive disorders is virtually nonexistent. We examined the prevalence of antipsychotic drug use and its effect on mortality among patients with Wernicke\u2013Korsakoff syndrome (WKS) or alcohol-related dementia (ARD). Methods: In this nationwide register study, we collected data on the medication use and mortality of all persons aged \u226540 diagnosed with WKS (n = 1149) or ARD (n = 2432) between 1998 and 2015 in Finland. We calculated the prevalence of antipsychotic use within one year of diagnosis and the adjusted cumulative mortality of antipsychotic users versus non-users in relation to the age-, sex-, and calendar year-matched general population. Results: Of the WKS and ARD patients, 35.9% and 38.5%, respectively, purchased one or more antipsychotic drugs in the year following diagnosis. The adjusted cumulative mortality of the antipsychotic users was significantly lower than that of non-users in both the WKS and ARD groups, where the adjusted hazard ratios (95% CI) were 0.85 (0.72\u20130.99) and 0.73 (0.65\u20130.81), respectively. WKS and ARD patients using antipsychotics were less likely to die of alcohol-related causes than antipsychotic non-users, but the difference was significant only in the ARD group. Conclusions: This population-based study shows that antipsychotic use is common in patients with WKS or ARD. In contrast to other dementia studies, our results indicate that the mortality of antipsychotic users is significantly lower than that of non-users. The lower mortality could be explained by decreased alcohol use and better healthcare coverage in antipsychotic users.<\/jats:p>","DOI":"10.3390\/jcm12134263","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T05:11:54Z","timestamp":1687756314000},"page":"4263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antipsychotic Use and Mortality in Persons with Alcohol-Related Dementia or Wernicke\u2013Korsakoff Syndrome: A Nationwide Register Study in Finland"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0719-295X","authenticated-orcid":false,"given":"Anniina","family":"Palm","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Helsinki University Hospital, 00029 Helsinki, Finland"},{"name":"University of Helsinki, 00014 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"Talaslahti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Helsinki University Hospital, 00029 Helsinki, Finland"},{"name":"University of Helsinki, 00014 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto","family":"Vataja","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Helsinki University Hospital, 00029 Helsinki, Finland"},{"name":"University of Helsinki, 00014 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Ginters","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Helsinki University Hospital, 00029 Helsinki, Finland"},{"name":"University of Helsinki, 00014 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Kautiainen","sequence":"additional","affiliation":[{"name":"Primary Health Care Unit, Kuopio University Hospital, 70210 Kuopio, Finland"},{"name":"Folkh\u00e4lsan Research Center, 00250 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Elonheimo","sequence":"additional","affiliation":[{"name":"Finnish Institute for Health and Welfare, 00271 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-0990","authenticated-orcid":false,"given":"Jaana","family":"Suvisaari","sequence":"additional","affiliation":[{"name":"Finnish Institute for Health and Welfare, 00271 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Lindberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Helsinki University Hospital, 00029 Helsinki, Finland"},{"name":"University of Helsinki, 00014 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Koponen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Helsinki University Hospital, 00029 Helsinki, Finland"},{"name":"University of Helsinki, 00014 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.psym.2017.02.012","article-title":"Alcohol-Related Dementia: A Systemic Review of Epidemiological Studies","volume":"58","author":"Cheng","year":"2017","journal-title":"Psychosomatics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/ggi.14043","article-title":"Incidence and Distribution of Subtypes of Early-onset Dementia in Japan: A Nationwide Analysis Based on Annual Performance Reports of the Medical Centers for Dementia","volume":"20","author":"Edahiro","year":"2020","journal-title":"Geriatr. 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