{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:25:47Z","timestamp":1790749547518,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Health Industry Development Institute (KHIDI)","award":["HI18C1216"],"award-info":[{"award-number":["HI18C1216"]}]},{"name":"Korea Health Industry Development Institute (KHIDI)","award":["2021R1A5A8029876"],"award-info":[{"award-number":["2021R1A5A8029876"]}]},{"name":"Ministry of Health &amp; Welfare","award":["HI18C1216"],"award-info":[{"award-number":["HI18C1216"]}]},{"name":"Ministry of Health &amp; Welfare","award":["2021R1A5A8029876"],"award-info":[{"award-number":["2021R1A5A8029876"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["HI18C1216"],"award-info":[{"award-number":["HI18C1216"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["2021R1A5A8029876"],"award-info":[{"award-number":["2021R1A5A8029876"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>It is well established that sarcopenic obesity (SO) is linked to many diseases such as metabolic and non-alcoholic fatty liver diseases, but there is little known about the relationship between SO and hepatic fibrosis progression in chronic liver disease. This study compared body composition contents in patients with non-obesity (NOb) and SO using abdominal magnetic resonance imaging and investigated the relationship between hepatic fibrosis and SO factors. This retrospective study enrolled 60 patients (28 NOb; 32 SO) from June 2014 to December 2020. Patients underwent histopathologic investigation where they classified fibrosis stages based on the Meta-analysis of Histological Data in Viral Hepatitis fibrosis scoring system. Muscle and fat areas at the third lumber vertebra level were assessed. The variation in the areas of muscle (MA), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) among fibrosis stages, and associations between hepatic fibrosis and SO factors, were analyzed. There were significant differences in SAT and VAT (p &lt; 0.001), whereas there was no difference in MA (p = 0.064). There were significant differences in MA\/SAT (p = 0.009), MA\/VAT (p &lt; 0.001), and MA\/(SAT+VAT) (p &lt; 0.001). In all the patients, hepatic fibrosis positively correlated with serum aspartate aminotransferase level (AST, R = 0.324; p = 0.025). Especially in SO patients, hepatic fibrosis closely correlated with body mass index (BMI, R = 0.443; p = 0.011), AST (R = 0.415; p = 0.044), VAT (R = 0.653; p &lt; 0.001), MA\/VAT (R = \u22120.605; p &lt; 0.001), and MA\/(SAT+VAT) (R = \u22120.416; p = 0.018). However, there was no association in NOb patients. This study demonstrated that SO patients had larger SAT and VAT than NOb patients. Hepatic fibrosis in SO positively correlated with body visceral fat composition in combination with BMI and AST level. These findings will be useful for understanding the relationship between the hepatic manifestation of fibrosis and body fat composition in sarcopenia and SO.<\/jats:p>","DOI":"10.3390\/jcm12134279","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T02:11:22Z","timestamp":1687831882000},"page":"4279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between Body Composition Contents and Hepatic Fibrosis in Sarcopenic Obesity"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2552-0665","authenticated-orcid":false,"given":"Tae-Hoon","family":"Kim","sequence":"first","affiliation":[{"name":"Medical Convergence Research Center, Wonkwang University, Wonkwang University Hospital, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Won","family":"Jeong","sequence":"additional","affiliation":[{"name":"Medical Convergence Research Center, Wonkwang University, Wonkwang University Hospital, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChungSub","family":"Lee","sequence":"additional","affiliation":[{"name":"Medical Convergence Research Center, Wonkwang University, Wonkwang University Hospital, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SiHyeong","family":"Noh","sequence":"additional","affiliation":[{"name":"Medical Convergence Research Center, Wonkwang University, Wonkwang University Hospital, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Lim","sequence":"additional","affiliation":[{"name":"Medical Convergence Research Center, Wonkwang University, Wonkwang University Hospital, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Woong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Chosun University Hospital of Medicine, Chosun University College, Gwangju 61453, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7591-9079","authenticated-orcid":false,"given":"Hyung Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youe Ree","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Wonkwang University Hospital, Wonkwang University School of Medicine, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.clnu.2018.04.018","article-title":"Sarcopenic obesity: Time to meet the challenge","volume":"37","author":"Barazzoni","year":"2018","journal-title":"Clin. 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