{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:22:27Z","timestamp":1789942947028,"version":"4.0.1"},"reference-count":40,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Birth asphyxia is a major cause of delivery room resuscitation. Subsequent organ failure and hypoxic\u2013ischemic encephalopathy (HIE) account for 25% of all early postnatal deaths. The neonatal sequential organ failure assessment (nSOFA) considers platelet count and respiratory and cardiovascular dysfunction in neonates with sepsis. To evaluate whether nSOFA is also a useful predictor for in-hospital mortality in neonates (\u226536 + 0 weeks of gestation (GA)) following asphyxia with HIE and therapeutic hypothermia (TH), (2) nSOFA was documented at \u22646 h of life. (3) A total of 65 infants fulfilled inclusion criteria for TH. All but one infant received cardiopulmonary resuscitation and\/or respiratory support at birth. nSOFA was lower in survivors (median 0 [IQR 0\u20132]; n = 56, median GA 39 + 3, female n = 28 (50%)) than in non-survivors (median 10 [4\u201312], p &lt; 0.001; n = 9, median GA 38 + 6, n = 4 (44.4%)). This was also observed for the respiratory (p &lt; 0.001), cardiovascular (p &lt; 0.001), and hematologic sub-scores (p = 0.003). The odds ratio for mortality was 1.6 [95% CI = 1.2\u20132.1] per one-point increase in nSOFA. The optimal cut-off value of nSOFA to predict mortality was 3.5 (sensitivity 100.0%, specificity 83.9%). (4) Since early accurate prognosis following asphyxia with HIE and TH is essential to guide decision making, nSOFA (\u22646 h of life) offers the possibility of identifying infants at risk of mortality.<\/jats:p>","DOI":"10.3390\/jcm12134322","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:45:11Z","timestamp":1687913111000},"page":"4322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Early Prediction of Mortality after Birth Asphyxia with the nSOFA"],"prefix":"10.3390","volume":"12","author":[{"given":"Anne-Kathrin","family":"Dathe","sequence":"first","affiliation":[{"name":"Neonatology, Paediatric Intensive Care and Paediatric Neurology, Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany"},{"name":"Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of Medicine, University Duisburg-Essen, 45122 Essen, Germany"},{"name":"Department of Health and Nursing, Occupational Therapy, Ernst-Abbe-University of Applied Sciences, 07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0497-4609","authenticated-orcid":false,"given":"Anja","family":"Stein","sequence":"additional","affiliation":[{"name":"Neonatology, Paediatric Intensive Care and Paediatric Neurology, Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany"},{"name":"Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of Medicine, University Duisburg-Essen, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3809-1887","authenticated-orcid":false,"given":"Nora","family":"Bruns","sequence":"additional","affiliation":[{"name":"Neonatology, Paediatric Intensive Care and Paediatric Neurology, Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany"},{"name":"Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of Medicine, University Duisburg-Essen, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena-Diana","family":"Craciun","sequence":"additional","affiliation":[{"name":"Neonatology, Paediatric Intensive Care and Paediatric Neurology, Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany"},{"name":"Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of Medicine, University Duisburg-Essen, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Tuda","sequence":"additional","affiliation":[{"name":"Neonatology, Paediatric Intensive Care and Paediatric Neurology, Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany"},{"name":"Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of Medicine, University Duisburg-Essen, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Bialas","sequence":"additional","affiliation":[{"name":"Neonatology, Paediatric Intensive Care and Paediatric Neurology, Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany"},{"name":"Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of Medicine, University Duisburg-Essen, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maire","family":"Brasseler","sequence":"additional","affiliation":[{"name":"Neonatology, Paediatric Intensive Care and Paediatric Neurology, Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany"},{"name":"Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of Medicine, University Duisburg-Essen, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Felderhoff-Mueser","sequence":"additional","affiliation":[{"name":"Neonatology, Paediatric Intensive Care and Paediatric Neurology, Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany"},{"name":"Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of Medicine, University Duisburg-Essen, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-5573","authenticated-orcid":false,"given":"Britta M.","family":"Huening","sequence":"additional","affiliation":[{"name":"Neonatology, Paediatric Intensive Care and Paediatric Neurology, Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany"},{"name":"Centre for Translational Neuro- and Behavioural Sciences, C-TNBS, Faculty of Medicine, University Duisburg-Essen, 45122 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1001\/archpedi.1995.02170130022005","article-title":"Cardiopulmonary resuscitation in the delivery room. Associated clinical events","volume":"149","author":"Perlman","year":"1995","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.resuscitation.2021.02.014","article-title":"European Resuscitation Council Guidelines 2021: Newborn resuscitation and support of transition of infants at birth","volume":"161","author":"Madar","year":"2021","journal-title":"Resuscitation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.clp.2016.04.002","article-title":"Pathophysiology of Birth Asphyxia","volume":"43","author":"Rainaldi","year":"2016","journal-title":"Clin. Perinatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.resuscitation.2008.08.004","article-title":"Ante- and intra-partum factors that predict increased need for neonatal resuscitation","volume":"79","author":"Aziz","year":"2008","journal-title":"Resuscitation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/ana.23647","article-title":"Neonatal encephalopathy: An inadequate term for hypoxic-ischemic encephalopathy","volume":"72","author":"Volpe","year":"2012","journal-title":"Ann. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch. Neurol."},{"key":"ref_7","unstructured":"World Health Organization (2023, January 26). Perinatal Asphyxia. Available online: https:\/\/www.who.int\/teams\/maternal-newborn-child-adolescent-health-and-ageing\/newborn-health\/perinatal-asphyxia."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1016\/S0140-6736(16)31593-8","article-title":"Global, regional, and national causes of under-5 mortality in 2000-15: An updated systematic analysis with implications for the Sustainable Development Goals","volume":"388","author":"Liu","year":"2016","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101265","DOI":"10.1016\/j.siny.2021.101265","article-title":"Neonatal encephalopathy: Focus on epidemiology and underexplored aspects of etiology","volume":"26","author":"McIntyre","year":"2021","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum. Dev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/archpediatrics.2011.1772","article-title":"Hypothermia for neonatal hypoxic ischemic encephalopathy: An updated systematic review and meta-analysis","volume":"166","author":"Tagin","year":"2012","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e771","DOI":"10.1542\/peds.2009-2441","article-title":"Systemic hypothermia after neonatal encephalopathy: Outcomes of neo.nEURO.network RCT","volume":"126","author":"Simbruner","year":"2010","journal-title":"Pediatrics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"Azzopardi","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/archpediatrics.2011.43","article-title":"Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: A randomized controlled trial","volume":"165","author":"Jacobs","year":"2011","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1111\/epi.13914","article-title":"Reduced infancy and childhood epilepsy following hypothermia-treated neonatal encephalopathy","volume":"58","author":"Liu","year":"2017","journal-title":"Epilepsia"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jpeds.2013.02.003","article-title":"Long-term neurodevelopmental outcome with hypoxic-ischemic encephalopathy","volume":"163","author":"Perez","year":"2013","journal-title":"J. Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5409\/wjcp.v5.i1.67","article-title":"Short and long term prognosis in perinatal asphyxia: An update","volume":"5","author":"Ahearne","year":"2016","journal-title":"World J. Clin. Pediatr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1001\/jama.2016.0289","article-title":"Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Phillips","year":"2016","journal-title":"JAMA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41390-019-0517-2","article-title":"A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants","volume":"88","author":"Wynn","year":"2020","journal-title":"Pediatr. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Berka, I., Korcek, P., Janota, J., and Stranak, Z. (2022). Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm Infants. Diagnostics, 12.","DOI":"10.3390\/diagnostics12061342"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e2036518","DOI":"10.1001\/jamanetworkopen.2020.36518","article-title":"Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants with Late-Onset Infection","volume":"4","author":"Fleiss","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"911444","DOI":"10.3389\/fped.2022.911444","article-title":"Evaluation of the neonatal sequential organ failure assessment and mortality risk in neonates with respiratory distress syndrome: A retrospective cohort study","volume":"10","author":"Shi","year":"2022","journal-title":"Front. Pediatr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/09732179221113672","article-title":"Utility of Neonatal Sequential Organ Failure Assessment (nSOFA) Score for Neonatal Mortality prediction","volume":"36","author":"Srikanth","year":"2022","journal-title":"J. Neonatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1097\/CCM.0b013e3181aa5241","article-title":"Mechanisms of action, physiological effects, and complications of hypothermia","volume":"37","author":"Polderman","year":"2009","journal-title":"Crit. Care Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/s41372-019-0371-4","article-title":"Correction: Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy","volume":"39","author":"Szakmar","year":"2019","journal-title":"J. Perinatol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Giannakis, S., Ruhfus, M., Markus, M., Stein, A., Hoehn, T., Felderhoff-Mueser, U., and Sabir, H. (2021). Mechanical Ventilation, Partial Pressure of Carbon Dioxide, Increased Fraction of Inspired Oxygen and the Increased Risk for Adverse Short-Term Outcomes in Cooled Asphyxiated Newborns. Children, 8.","DOI":"10.3390\/children8060430"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0301-2115(98)00325-X","article-title":"Dynamics of fetal circulatory responses to hypoxia and asphyxia","volume":"84","author":"Jensen","year":"1999","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/trf.12777","article-title":"Thrombocytopenia in late preterm and term neonates after perinatal asphyxia","volume":"55","author":"Christensen","year":"2015","journal-title":"Transfusion"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"760654","DOI":"10.1155\/2014\/760654","article-title":"Neonatal thrombocytopenia after perinatal asphyxia treated with hypothermia: A retrospective case control study","volume":"2014","author":"Boutaybi","year":"2014","journal-title":"Int. J. Pediatr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00000658-198702000-00012","article-title":"Hypothermia-induced reversible platelet dysfunction","volume":"205","author":"Valeri","year":"1987","journal-title":"Ann. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/jp.2009.37","article-title":"Effects of therapeutic hypothermia on multiorgan dysfunction in asphyxiated newborns: Whole-body cooling versus selective head cooling","volume":"29","author":"Sarkar","year":"2009","journal-title":"J. Perinatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jpeds.2020.07.041","article-title":"Death after Birth Asphyxia in the Cooling Era","volume":"226","author":"Racine","year":"2020","journal-title":"J. Pediatr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e459","DOI":"10.1542\/peds.2008-2190","article-title":"Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years","volume":"124","author":"Murray","year":"2009","journal-title":"Pediatrics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e382","DOI":"10.1542\/peds.2009-1046","article-title":"Cerebral magnetic resonance biomarkers in neonatal encephalopathy: A meta-analysis","volume":"125","author":"Thayyil","year":"2010","journal-title":"Pediatrics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"F11","DOI":"10.1136\/adc.2003.048488","article-title":"Neonatal disease severity scoring systems","volume":"90","author":"Dorling","year":"2005","journal-title":"Arch. Dis. Childhood Fetal Neonatal Ed."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1080\/14767058.2017.1315665","article-title":"Assessment of sickness severity of illness in neonates: Review of various neonatal illness scoring systems","volume":"31","author":"Garg","year":"2018","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41390-020-01143-5","article-title":"The Sarnat score for neonatal encephalopathy: Looking back and moving forward","volume":"88","author":"Mrelashvili","year":"2020","journal-title":"Pediatr. Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/13\/4322\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:02:09Z","timestamp":1760126529000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/13\/4322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":40,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["jcm12134322"],"URL":"https:\/\/doi.org\/10.3390\/jcm12134322","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]}}}