{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:02:57Z","timestamp":1794045777768,"version":"4.8.0"},"reference-count":16,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Griffith University\u2019s School of Medicine and Dentistry"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Our research aimed to explore how resolving periodontal inflammation impacts cytokine expression in the colons of aged Wistar rats. Research studies involving animals have been conducted to investigate the two-way relationship between periodontitis and inflammatory bowel disease (IBD), where chronic inflammation in either the mouth or intestines can negatively affect the other. We allocated seventeen male Wistar rats aged between 8 and 11 months to one of four groups: (1) ligature-induced periodontitis (LIP) without the resolution of periodontal inflammation (RPI) (LIP; n = 4), (2) LIP + RPI (n = 4), (3) LIP + dextran-sulphate-sodium-induced colitis (DIC) without RPI (n = 4), and LIP + DIC + RPI (n = 5). We performed histopathological and immunological analyses on periodontal and intestinal tissues and analysed cytokine expressions using a Rat Cytokine 23-Plex Immunoassay. Our findings showed that animals with and without DIC who underwent RPI showed significantly lower levels of IL-2, IL-4, IL-5, IL-10, IL-13, IL-17, IL-18, and TNF-\u03b1 in the intestine compared to those without treatment. The RPI effectively reduced the number of inflammatory cells in the lamina propria and restored the epithelial barrier in the intestine in animals with DIC. The resolution of periodontal inflammation significantly reduced the levels of pro-inflammatory cytokines and chemokines in the intestines of aged rats with and without DSS-induced colitis.<\/jats:p>","DOI":"10.3390\/jcm12134326","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:45:11Z","timestamp":1687913111000},"page":"4326","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Resolution of Periodontal Inflammation Promotes Changes in Cytokine Expression in the Intestine and Gingival Tissues of Aged Rats with DSS-Induced Colitis"],"prefix":"10.3390","volume":"12","author":[{"given":"Jo\u00e3o Martins","family":"de Mello-Neto","sequence":"first","affiliation":[{"name":"College of Medicine and Dentistry, James Cook University, Cairns, QLD 4870, Australia"},{"name":"School of Medicine and Dentistry, Griffith University, Brisbane, QLD 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edilson","family":"Ervolino","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, School of Dentistry, S\u00e3o Paulo State University-UNESP, Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8858-639X","authenticated-orcid":false,"given":"Gayathiri","family":"Elangovan","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University, Brisbane, QLD 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan Felipe","family":"Toro","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, School of Dentistry, S\u00e3o Paulo State University-UNESP, Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehee","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University, Brisbane, QLD 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0222-9231","authenticated-orcid":false,"given":"Carlos Marcelo da Silva","family":"Figueredo","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University, Brisbane, QLD 4111, Australia"},{"name":"Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"620124","DOI":"10.3389\/fimmu.2021.620124","article-title":"The \u201cGum-Gut\u201d Axis in Inflammatory Bowel Diseases: A Hypothesis-Driven Review of Associations and Advances","volume":"12","author":"Byrd","year":"2021","journal-title":"Front. 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