{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:06:57Z","timestamp":1790690817608,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The aims of our study were to evaluate the maternal and fetal outcomes of intrahepatic cholestasis of pregnancy (ICP). In this observational, retrospective case\u2013control study, we included all pregnant women who gave birth with a diagnosis of ICP between January 2010 and December 2020 at the Unit of Obstetrics and Gynecology, University Hospital of Messina. The data were compared with those from a control group of pregnant women who did not have ICP. One hundred twenty-nine and eighty-five patients were included, respectively, in the study and in the control group. There was a significant difference between the two groups in the incidence of hypothyroidism, thrombophilia, gestational diabetes, gestational hypertension, postpartum hemorrhage, and preterm delivery, which were more frequent in the ICP patients. No neonatal adverse events were recorded, although a significant difference in the meconium-stained amniotic fluid condition was noted. After a 24-month follow-up, 48\/129 patients with ICP accepted to be reassessed by liver ultrasound, elastographic examination, and liver function blood tests. No patient showed signs of chronic liver disease. This study confirmed a higher probability of adverse short-term maternal outcomes in ICP pregnant patients, but a lower probability of adverse short-term fetal outcomes and the absence of a long-term maternal risk of chronic liver disease.<\/jats:p>","DOI":"10.3390\/jcm12134407","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:49:27Z","timestamp":1688345367000},"page":"4407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Maternal and Neonatal Outcomes in Intrahepatic Cholestasis of Pregnancy"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0318-9390","authenticated-orcid":false,"given":"Roberta","family":"Granese","sequence":"first","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University Hospital \u201cG. Martino\u201d, Via Consolare Valeria 1, Gazzi, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-986X","authenticated-orcid":false,"given":"Gloria","family":"Calagna","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, \u201cVilla Sofia Cervello\u201d Hospital, University of Palermo, Via Trabucco 180, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-151X","authenticated-orcid":false,"given":"Angela","family":"Alibrandi","sequence":"additional","affiliation":[{"name":"Department of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, Via dei Verdi, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canio","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adulthood and Childhood, University Hospital \u201cG. Martino\u201d, Via Consolare Valeria 1, Gazzi, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adulthood and Childhood, University Hospital \u201cG. Martino\u201d, Via Consolare Valeria 1, Gazzi, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Filomia","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University Hospital \u201cG. Martino\u201d, Via Consolare Valeria 1, Gazzi, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Immacolata","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Family Counseling, ASP Messina, Via Catania 14, Sant\u2019Agata di Militello, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Piccione","sequence":"additional","affiliation":[{"name":"Family Counseling, ASP Messina, Via Trento 8, Brolo, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ercoli","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adulthood and Childhood, University Hospital \u201cG. Martino\u201d, Via Consolare Valeria 1, Gazzi, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Saitta","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University Hospital \u201cG. Martino\u201d, Via Consolare Valeria 1, Gazzi, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"ref_1","first-page":"713","article-title":"Clinical practice guidlines of team of experts of the polish gynecolical society: Managment of intrahepatic cholestasis of pregnancy","volume":"83","author":"Oleszczuk","year":"2012","journal-title":"Ginekol. Pol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1157\/13111695","article-title":"Cholestasis of pregnancy","volume":"30","author":"Lorente","year":"2007","journal-title":"Gastroenterol. 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