{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:23:53Z","timestamp":1792805033459,"version":"4.5.0"},"reference-count":24,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kaohsiung Municipal Ta-Tung Hospital","award":["KMTTH-108-056"],"award-info":[{"award-number":["KMTTH-108-056"]}],"id":[{"id":"https:\/\/ror.org\/03db90279","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Kaohsiung Municipal Ta-Tung Hospital","award":["KMTTH-110-056"],"award-info":[{"award-number":["KMTTH-110-056"]}],"id":[{"id":"https:\/\/ror.org\/03db90279","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Kaohsiung Municipal Ta-Tung Hospital","award":["KMTTH-111-041"],"award-info":[{"award-number":["KMTTH-111-041"]}],"id":[{"id":"https:\/\/ror.org\/03db90279","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Acne vulgaris remains the leading dermatological condition. The efficacy of laser treatment has been supported by many clinical studies, but studies investigating its multidimensional action are lacking. Aim: To comprehensively investigate the efficacy of 1450-nm diode laser treatment in patients with inflammatory acne and provide objective and subjective data for doctors in clinical practice. Methods: This retrospective study included patients with inflammatory acne lesions who underwent three courses of 1450-nm diode laser treatment between October 2019 and August 2020. Facial surface analysis was performed via objective computer assessments using the Canfield VISIA imaging system. Post-treatment subjective assessments were retrieved and analyzed using the clinical global impression\u2013improvement index (CGI-I) and patient global impression of improvement scales (PGI-I). Results: The final analysis included 20 patients. The changes in the porphyrin VISIA system scores demonstrated significant improvement, with median scores being 35.83, 48.83, and 54.83, respectively. The changes in the red area VISIA scores also showed improvement, with the median scores being 48, 50.33, and 58.83, respectively. The average CGI-I scale scores were 2.2 \u00b1 1.01, 1.70 \u00b1 0.80, and 1.50 \u00b1 0.76, respectively (p = 0.001), and the average PGI-I scale scores were 3.10 \u00b1 0.85, 3.10 \u00b1 0.97, and 3.05 \u00b1 0.95, respectively (p = 0.727), with no significant changes observed in sebum production. Conclusions: The present study is the first to provide objective and subjective evidence proving that the 1450-nm diode laser can reduce inflammatory acne lesions.<\/jats:p>","DOI":"10.3390\/jcm12134500","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:41:27Z","timestamp":1688604087000},"page":"4500","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The 1450-nm Diode Laser Reduces Redness and Porphyrin Density: An Image-Based, Patient-Oriented Appraisal"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3693-0739","authenticated-orcid":false,"given":"Gong-Yau","family":"Chu","sequence":"first","affiliation":[{"name":"Institute of Traditional Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei 30010, Taiwan"},{"name":"Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 30010, Taiwan"},{"name":"Department of Dermatology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan"},{"name":"Department of Dermatology, Kang-Ning General Hospital, Taipei 114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Hua","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hua","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Traditional Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei 30010, Taiwan"},{"name":"Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 30010, Taiwan"},{"name":"Department of Chinese Medicine, Taipei City Hospital, Linsen Chinese Medicine and Kunming Branch, Taipei 104, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan"},{"name":"Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80756, Taiwan"},{"name":"Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan 61363, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1525-1470.1991.tb00856.x","article-title":"Psychological aspects of acne","volume":"8","author":"Koo","year":"1991","journal-title":"Pediatr. 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