{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:24:49Z","timestamp":1780604689263,"version":"3.54.1"},"reference-count":79,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["N41\/DBS\/000032"],"award-info":[{"award-number":["N41\/DBS\/000032"]}]},{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["N41\/DBS\/000665"],"award-info":[{"award-number":["N41\/DBS\/000665"]}]},{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["K\/ZDS\/003761"],"award-info":[{"award-number":["K\/ZDS\/003761"]}]},{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["K\/ZDS\/006104"],"award-info":[{"award-number":["K\/ZDS\/006104"]}]},{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["K\/ZDS\/006105"],"award-info":[{"award-number":["K\/ZDS\/006105"]}]},{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["N41\/DBS\/000138"],"award-info":[{"award-number":["N41\/DBS\/000138"]}]},{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["N41\/DBS\/000032"],"award-info":[{"award-number":["N41\/DBS\/000032"]}]},{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["N41\/DBS\/000665"],"award-info":[{"award-number":["N41\/DBS\/000665"]}]},{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["K\/ZDS\/003761"],"award-info":[{"award-number":["K\/ZDS\/003761"]}]},{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["K\/ZDS\/006104"],"award-info":[{"award-number":["K\/ZDS\/006104"]}]},{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["K\/ZDS\/006105"],"award-info":[{"award-number":["K\/ZDS\/006105"]}]},{"name":"Jagiellonian University Medical College (Cracow, Poland)","award":["N41\/DBS\/000138"],"award-info":[{"award-number":["N41\/DBS\/000138"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The degree of platelet inhibition in patients undergoing dual antiplatelet therapy (DAPT) affects cardiovascular outcomes after acute coronary syndromes (ACS) and\/or percutaneous coronary intervention. Our aim was to search for correlates of residual ex vivo platelet reactivity and circulating soluble P-selectin (sP-selectin), an index of in vivo platelet activation, in patients being treated by DAPT with ticagrelor. Adenosine diphosphate (ADP)-induced platelet aggregability (by multiple electrode aggregometry) and plasma sP-selectin were estimated in 62 stable post-ACS subjects (46 men and 16 women; mean age: 64 \u00b1 10 years; 30 with type 2 diabetes (T2DM)) undergoing maintenance DAPT with ticagrelor and aspirin. These patients did not exhibit heart failure or other relevant coexistent diseases except for properly controlled T2DM, mild renal insufficiency, and hypertension. We also assessed this in 64 subjects on clopidogrel-based DAPT matched for age, sex, and T2DM status. ADP-induced platelet aggregation was below the optimal levels (190\u2013460 arbitrary units (AU) * min) in most patients receiving ticagrelor-based DAPT, especially in those with below-median (&lt;1.9 mmol\/L) serum concentrations of low-density lipoprotein cholesterol (LDL-c) (128 \u00b1 61 vs. 167 \u00b1 73 AU * min for below-median and above-median LDL-c, respectively, p = 0.025). In contrast, platelet reactivity did not differ by LDL-c on clopidogrel-based DAPT (246 \u00b1 101 vs. 268 \u00b1 108 AU * min for below-median and above-median LDL-c, respectively, p &gt; 0.4). Plasma sP-selectin was found to be unrelated to serum LDL-c when receiving DAPT with ticagrelor (p &gt; 0.4) or clopidogrel (p &gt; 0.8). In conclusion, our preliminary observational study suggests the association of lower residual ex vivo platelet aggregability with better LDL-c control in patients undergoing ticagrelor-based maintenance DAPT, which does not appear to be reflected by plasma sP-selectin. Whether the serum LDL-c level should be considered among the factors affecting the degree of platelet inhibition for those treated with ticagrelor-based DAPT needs to be investigated in larger studies.<\/jats:p>","DOI":"10.3390\/jcm12134530","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T01:57:09Z","timestamp":1688695029000},"page":"4530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of ADP-Induced Whole-Blood Platelet Aggregation with Serum Low-Density Lipoprotein Cholesterol in Patients with Coronary Artery Disease When Receiving Maintenance Ticagrelor-Based Dual Antiplatelet Therapy"],"prefix":"10.3390","volume":"12","author":[{"given":"Bernadeta","family":"Chyrchel","sequence":"first","affiliation":[{"name":"Second Department of Cardiology, Institute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, 2 Jakubowskiego Street, 30-688 Cracow, Poland"},{"name":"Department of Cardiology and Cardiovascular Interventions, University Hospital, 2 Jakubowskiego Street, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kruszelnicka","sequence":"additional","affiliation":[{"name":"Department of Coronary Artery Disease and Heart Failure, Institute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, 80 Pr\u0105dnicka Street, 31-202 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wieczorek-Surdacka","sequence":"additional","affiliation":[{"name":"Center of Innovative Medical Education, Jagiellonian University Medical College, 7 Medyczna Street, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7949-3140","authenticated-orcid":false,"given":"Andrzej","family":"Surdacki","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology, Institute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, 2 Jakubowskiego Street, 30-688 Cracow, Poland"},{"name":"Department of Cardiology and Cardiovascular Interventions, University Hospital, 2 Jakubowskiego Street, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.jacc.2007.05.049","article-title":"Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease","volume":"50","author":"Angiolillo","year":"2007","journal-title":"J. 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