{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:17:57Z","timestamp":1760149077379,"version":"build-2065373602"},"reference-count":126,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Research Foundation\u2019s (DFG) Open Access Publishing funding program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The aging global patient population with multimorbidity and concomitant polypharmacy is at increased risk for acute and chronic kidney disease, particularly with severe additional disease states or invasive surgical procedures. Because from the expertise of more than 58,600 self-reviewed medications, adverse drug reactions, drug interactions, inadequate dosing, and contraindications all proved to cause or exacerbate the worsening of renal function, we analyzed the association of an electronic patient record- and Summaries of Product Characteristics (SmPCs)-based comprehensive individual pharmacotherapy management (IPM) in the setting of 14 daily interdisciplinary patient visits with the outcome: further renal impairment with reduction of eGFR \u2265 20 mL\/min (redGFR) in hospitalized trauma patients \u2265 70 years of age. The retrospective clinical study of 404 trauma patients comparing the historical control group (CG) before IPM with the IPM intervention group (IG) revealed a group-match in terms of potential confounders such as age, sex, BMI, arterial hypertension, diabetes mellitus, and injury patterns. Preexisting chronic kidney disease (CKD) &gt; stage 2 diagnosed as eGFR &lt; 60 mL\/min\/1.73 m2 on hospital admission was 42% in the CG versus 50% in the IG, although in each group only less than 50% of this was coded as an ICD diagnosis in the patients\u2019 discharge letters (19% in CG and 21% in IG). IPM revealed an absolute risk reduction in redGFR of 5.5% (11 of 199 CG patients) to 0% in the IPM visit IG, a relative risk reduction of 100%, NNT 18, indicating high efficacy of IPM and benefit in improving outcomes. There even remained an additive superimposed significant association that included patients in the IPM group before\/beyond the 14 daily IPM interventions, with a relative redGFR risk reduction of 0.55 (55%) to 2.5% (5 of 204 patients), OR 0.48 [95% CI 0.438\u20130.538] (p &lt; 0.001). Bacteriuria, loop diuretics, allopurinol, eGFR \u2265 60 mL\/min\/1.73 m2, eGFR &lt; 60 mL\/min\/1.73 m2, and CKD 3b were significantly associated with redGFR; of the latter, 10.5% developed redGFR. Further multivariable regression analysis adjusting for these and established risk factors revealed an additive, superimposed IPM effect on redGFR with an OR 0.238 [95% CI 0.06\u20130.91], relative risk reduction of 76.2%, regression coefficient \u22121.437 including patients not yet visited in the IPM period. As consequences of the IPM procedure, the IG differed from the CG by a significant reduction of NSAIDs (p &lt; 0.001), HCT (p = 0.028) and W\u00fcrzburger pain drip (p &lt; 0.001), and significantly increased prescription rate of antibiotics (p = 0.004). In conclusion, (1) more than 50% of CKD in geriatric patients was not pre-recognized and underdiagnosed, and (2) the electronic patient records-based IPM interdisciplinary networking strategy was associated with effective prevention of further periinterventional renal impairment and requires obligatory implementation in all elderly patients to urgently improve patient and drug safety.<\/jats:p>","DOI":"10.3390\/jcm12134545","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:54:23Z","timestamp":1688950463000},"page":"4545","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Underdiagnosed CKD in Geriatric Trauma Patients and Potent Prevention of Renal Impairment from Polypharmacy Risks through Individual Pharmacotherapy Management (IPM-III)"],"prefix":"10.3390","volume":"12","author":[{"given":"Ursula","family":"Wolf","sequence":"first","affiliation":[{"name":"Pharmacotherapy Management, University Hospital Halle (Saale), Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Ghadir","sequence":"additional","affiliation":[{"name":"Medical Clinic II, University Hospital Schleswig-Holstein, L\u00fcbeck Campus, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luise","family":"Drewas","sequence":"additional","affiliation":[{"name":"Internal Medicine Clinic II, Martha-Maria Hospital Halle-D\u00f6lau, 06120 Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Neef","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Trauma and Reconstructive Surgery, Division of Geriatric Traumatology, University Hospital Halle (Saale), Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, October 08). Quality Assurance and Safety of Medicines Team. The Safety of Medicines in Public Health Programmes: Pharmacovigilance, an Essential Tool. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/43384."},{"key":"ref_2","unstructured":"World Health Organization (2023, February 10). Medication Without Harm\u2014Global Patient Safety Challenge on Medication Safety. Geneva: World Health Organization. 2017. Licence: CC BY-NC-SA 3.0 IGO. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/255263\/WHO-HIS-SDS-2017.6-eng.pdf."},{"key":"ref_3","unstructured":"(2023, February 10). World Health Assembly, 73 (2020). Decade of Healthy Ageing: The Global Strategy and Action Plan on Ageing and Health 2016\u20132020: Towards a World in Which Everyone Can Live a Long and Healthy Life: Report by the Director-General. World Health Organization. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/355618."},{"key":"ref_4","unstructured":"(2023, February 10). The UN Decade of Healthy Ageing (2021\u20132030). Available online: https:\/\/www.un.org\/en\/UN-system\/ageing."},{"key":"ref_5","unstructured":"United Nations (2023, February 10). General Assembly Seventy-Fifth Session Agenda Item 131. Global Health and Foreign Policy. Resolution Adopted by the General Assembly on 14 December 2020. 75\/131. United Nations Decade of Healthy Ageing (2021\u20132030). Available online: https:\/\/documents-dds-ny.un.org\/doc\/UNDOC\/GEN\/N20\/363\/87\/PDF\/N2036387.pdf?OpenElement."},{"key":"ref_6","unstructured":"The Health Care Quality Indicators Team Final Report (2023, February 10). Data and Analysis of Data on Patient Safety within the OECD Health Care Quality Indicators Project (OECD-PS). 2018, 1\u2013294. Available online: https:\/\/ec.europa.eu\/chafea\/health\/documents\/OECD-Patient-Safety-VS-2015-5402-D00035-FINAL.pdf."},{"key":"ref_7","unstructured":"United Nations, Department of Economic and Social Affairs, Population Devision (2019). Highlights, United Nations, Department of Economic and Social Affairs. Available online: https:\/\/www.un.org\/en\/development\/desa\/population\/publications\/pdf\/ageing\/WorldPopulationAgeing2019-Highlights.pdf."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Drewas, L., Ghadir, H., Neef, R., Delank, K.S., and Wolf, U. (2022). Individual Pharmacotherapy Management (IPM)\u2014I: A group-matched retrospective controlled clinical study on prevention of complicating delirium in the elderly trauma patients and identification of associated factors. BMC Geriatr., 22.","DOI":"10.1186\/s12877-021-02630-y"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"21955","DOI":"10.1038\/s41598-021-99858-w","article-title":"Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs","volume":"11","author":"Wolf","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Clifford, K.M., Selby, A.R., Reveles, K.R., Teng, C., Hall, R.G., McCarrell, J., and Alvarez, C.A. (2022). The Risk and Clinical Implications of Antibiotic-Associated Acute Kidney Injury: A Review of the Clinical Data for Agents with Signals from the Food and Drug Administration\u2019s Adverse Event Reporting System (FAERS) Database. Antibiotics, 11.","DOI":"10.3390\/antibiotics11101367"},{"key":"ref_11","unstructured":"US Centers for Disease Control and Prevention (CDC) (2023, February 18). Chronic Kidney Disease Initiative. Chronic Kidney Disease Basics. Page Last Reviewed: 28 February 2022, Available online: https:\/\/www.cdc.gov\/kidneydisease\/basics.html."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100438","DOI":"10.1016\/j.lanepe.2022.100438","article-title":"Prevalence, outcomes, and cost of chronic kidney disease in a contemporary population of 2\u00b74 million patients from 11 countries: The CaReMe CKD study","volume":"20","author":"Bodegard","year":"2022","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_13","first-page":"85","article-title":"The Prevalence of Renal Failure. Results from the German Health Interview and Examination Survey for Adults, 2008\u20132011 (DEGS1)","volume":"113","author":"Girndt","year":"2016","journal-title":"Dtsch. \u00c4rzteblatt Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.7326\/0003-4819-157-7-201210020-00003","article-title":"Two novel equations to estimate kidney function in persons aged 70 years or older","volume":"157","author":"Schaeffner","year":"2012","journal-title":"Ann. Intern. Med."},{"key":"ref_15","unstructured":"Statistisches Bundesamt Deutschland (2022, October 15). Koordinierte Bev\u00f6lkerungsvorausberechnung. Available online: https:\/\/www.destatis.de\/DE\/Themen\/Gesellschaft-Umwelt\/Bevoelkerung\/_inhalt.html."},{"key":"ref_16","unstructured":"Bundeszentrale f\u00fcr Politische Bildung (2023, February 17). Bev\u00f6lkerung Nach Altersgruppen und Geschlecht. Available online: https:\/\/www.bpb.de\/kurz-knapp\/zahlen-und-fakten\/soziale-situation-in-deutschland\/61538\/bevoelkerung-nach-altersgruppen-und-geschlecht\/."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wolf, U., Baust, H., Neef, R., and Steinke, T. (2022). Individual Pharmacotherapy Management (IPM)\u2014IV: Optimized Usage of Approved Antimicrobials Addressing Under-Recognized Adverse Drug Reactions and Drug-Drug Interactions in Polypharmacy. Antibiotics, 11.","DOI":"10.3390\/antibiotics11101381"},{"key":"ref_18","unstructured":"Ghadir, H. (2023). Klinisch-pharmakologische Visiten in der Alterstraumatologie\u2014M\u00f6glichkeit der Pr\u00e4vention Einer Nierenfunktionsverschlechterung und Definition Pr\u00e4disponierender Faktoren. [Doctoral Thesis, Medizinische Fakult\u00e4t der Martin-Luther-Universit\u00e4t Halle-Wittenberg]."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.ajkd.2009.12.034","article-title":"Acute kidney injury in elderly persons","volume":"56","author":"Coca","year":"2010","journal-title":"Am. J. Kidney Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"ref_21","first-page":"313","article-title":"La ecuaci\u00f3n de Cockcroft-Gault es preferible a la ecuaci\u00f3n MDRD para medir el filtrado glomerular en la insuficiencia renal cr\u00f3nica avanzada [The Cockcroft-Gault equation is better than MDRD equation to estimate the glomerular filtration rate in patients with advanced chronic renal failure]","volume":"27","author":"Teruel","year":"2007","journal-title":"Nefrol. Publ. Of. Soc. Esp. Nefrol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"c172","DOI":"10.1159\/000317197","article-title":"Should We Continue to Use the Cockcroft-Gault Formula?","volume":"116","author":"Helou","year":"2010","journal-title":"Nephron Clin. Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1001\/jama.2012.3954","article-title":"Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate","volume":"307","author":"Matsushita","year":"2012","journal-title":"JAMA"},{"key":"ref_24","unstructured":"Drugs.com (2023, March 10). Drug Interaction Checker. Check for Multi-Drug Interactions Including Alcohol, Food, Supplements & Diseases. Available online: https:\/\/www.drugs.com\/drug_interactions.html."},{"key":"ref_25","unstructured":"Dosing (2023, March 10). Arzneimitteldosierung bei Niereninsuffizienz. Available online: https:\/\/dosing.de\/."},{"key":"ref_26","unstructured":"Single Care (2023, March 10). Piperacillin Sod-Tazobactam So Side Effects, Interactions, and Warnings. Available online: https:\/\/www.singlecare.com\/prescription\/piperacillin-sod-tazobactam-so\/side-effects."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40780-019-0142-6","article-title":"Higher incidence of acute kidney injury in patients treated with piperacillin\/tazobactam than in patients treated with cefepime: A single-center retrospective cohort study","volume":"5","author":"Kadomura","year":"2019","journal-title":"J. Pharm. Health Care Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1248\/bpb.b14-00362","article-title":"Nephrotoxicity induced by piperacillin\u2013tazobactam in late elderly Japanese patients with nursing and healthcare associated pneumonia","volume":"37","author":"Karino","year":"2014","journal-title":"Biol. Pharm. Bull."},{"key":"ref_29","unstructured":"(2023, February 20). Pravastatin-CT 20 mg\/40 mg Tabletten. Fachinformation September 2018. Available online: https:\/\/s3.eu-central-1.amazonaws.com\/prod-cerebro-ifap\/media_all\/88578.pdf."},{"key":"ref_30","unstructured":"(2023, February 22). Moxonidin AL 0.2 mg\/- 0.3 mg\/- 0.4 mg Filmtabletten. Fachinformation January 2015. Available online: https:\/\/s3.eu-central-1.amazonaws.com\/prod-cerebro-ifap\/media_all\/58210.pdf."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2710.2005.00672.x","article-title":"Use of moxonidine in elderly patients with resistant hypertension","volume":"30","author":"Martin","year":"2005","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_32","unstructured":"(2023, February 22). Allopurinol-Ratiopharm Tabletten. Fachinformation November 2017. Available online: https:\/\/www.ratiopharm.de\/assets\/products\/de\/label\/Allopurinol-ratiopharm%20100%20mg%20300%20mg%20Tabletten%20-%20Version%202.pdf?pzn=1686206."},{"key":"ref_33","unstructured":"(2023, February 22). Carvedilol AL 3.125 mg\/- 6.25 mg\/- 12.5 mg\/- 25 mg Tabletten. Fachinformation February 2017. Available online: https:\/\/fachinformation.srz.de\/pdf\/aliudpharma\/carvedilolaltabletten.pdf."},{"key":"ref_34","first-page":"692","article-title":"Metoprolol and sertraline combined treatment may increase the risk of bradycardia","volume":"37","author":"Protopapas","year":"2020","journal-title":"Arch. Hell. Med.\/Arheia Ellenikes Iatr."},{"key":"ref_35","unstructured":"(2023, February 22). Ramipril\u20141 A Pharma\u00ae Tabletten. Fachinformation January 2019. Available online: https:\/\/s3.eu-central-1.amazonaws.com\/prod-cerebro-ifap\/media_all\/91537.pdf."},{"key":"ref_36","unstructured":"(2023, February 22). Enalapril-CT 5 mg\/10 mg\/20 mg Tabletten. Fachinformation April 2017. Available online: https:\/\/s3.eu-central-1.amazonaws.com\/prod-cerebro-ifap\/media_all\/77352.pdf."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1002\/ehf2.12832","article-title":"Sequential nephron blockade with combined diuretics improves diastolic function in patients with resistant hypertension","volume":"7","author":"Fouassier","year":"2020","journal-title":"ESC Heart Fail."},{"key":"ref_38","unstructured":"(2023, February 22). Alendronat acis\u00ae 70 mg Tabletten. Fachinformation Juni 2017. Available online: https:\/\/s3.eu-central-1.amazonaws.com\/prod-cerebro-ifap\/media_all\/79077.pdf."},{"key":"ref_39","unstructured":"(2023, February 22). Metformin Aristo N 500 mg\/- 850 mg\/- 1000 mg Filmtabletten. Fachinformation July 2017. Available online: https:\/\/fachinformation.srz.de\/pdf\/aristo\/metforminariston5008501000mgfilmtabletten.pdf."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrendo.2013.256","article-title":"Metformin\u2014Mode of action and clinical implications for diabetes and cancer","volume":"10","author":"Pernicova","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"696","DOI":"10.2337\/db07-1098","article-title":"Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling","volume":"57","author":"Calvert","year":"2008","journal-title":"Diabetes"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tem.2015.05.010","article-title":"AMPK: Energy sensor and survival mechanism in the ischemic heart","volume":"26","author":"Qi","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"97977","DOI":"10.18632\/oncotarget.20105","article-title":"Metformin ameliorates sepsis-induced brain injury by inhibiting apoptosis, oxidative stress and neuroinflammation via the PI3K\/Akt signaling pathway","volume":"8","author":"Tang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_44","unstructured":"(2023, February 22). Metamizol AbZ 500 mg Tabletten. Fachinformation 2017. Available online: https:\/\/www.abz.de\/assets\/products\/de\/label\/Metamizol%20AbZ%20500%20mg%20Tabletten%20-%20Version%202.pdf?pzn=943603."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3109\/0886022X.2011.569107","article-title":"Acute kidney injury associated with metamizole sodium ingestion","volume":"33","author":"Hassan","year":"2011","journal-title":"Ren. Fail."},{"key":"ref_46","unstructured":"(2023, February 22). Spasmex 45 mg Filmtabletten\u2014Trospiumchlorid. Fachinformation July 2017. Available online: https:\/\/s3.eu-central-1.amazonaws.com\/prod-cerebro-ifap\/media_all\/78731.pdf."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1755-5949.2011.00248.x","article-title":"Anticholinergics for overactive bladder therapy: Central nervous system effects","volume":"18","author":"Chancellor","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1053\/j.ackd.2010.03.010","article-title":"Chronic kidney disease and end-stage renal disease in the elderly population: Current prevalence, future projections, and clinical significance","volume":"17","author":"Stevens","year":"2010","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"183","DOI":"10.31128\/AJGP-11-20-5752","article-title":"Prescribing and deprescribing in chronic kidney disease","volume":"50","author":"McMorrow","year":"2021","journal-title":"Aust. J. Gen. Pract."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000517708","article-title":"Aging-Related Kidney Diseases","volume":"199","author":"Kitai","year":"2021","journal-title":"Contrib. Nephrol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrneph.2016.183","article-title":"Cellular senescence in renal ageing and disease","volume":"13","author":"Sturmlechner","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1681\/ASN.2015121308","article-title":"Renal Aging: Causes and Consequences","volume":"28","author":"Hughes","year":"2017","journal-title":"JASN"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/path.2111","article-title":"Renal ageing","volume":"211","author":"Martin","year":"2007","journal-title":"J. Pathol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"By the 2019 American Geriatrics Society Beers Criteria\u00ae Update Expert Panel (2019). American Geriatrics Society 2019 Updated AGS Beers Criteria\u00ae for Potentially Inappropriate Medication Use in Older Adults. J. Am. Geriatr. Soc., 67, 674\u2013694.","DOI":"10.1111\/jgs.15767"},{"key":"ref_56","first-page":"213","article-title":"STOPP\/START criteria for potentially inappropriate prescribing in older people: Version 2","volume":"44","author":"Byrne","year":"2015","journal-title":"Age Ageing"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/17512433.2020.1697676","article-title":"STOPP\/START criteria for potentially inappropriate medications\/potential prescribing omissions in older people: Origin and progress","volume":"13","year":"2020","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s40266-013-0118-4","article-title":"The medication appropriateness index at 20: Where it started, where it has been, and where it may be going","volume":"30","author":"Hanlon","year":"2013","journal-title":"Drugs Aging"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000521699","article-title":"The Medication Appropriateness Index: A Clinimetric Measure","volume":"91","author":"Hanlon","year":"2022","journal-title":"Psychother. Psychosom."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s40266-013-0146-0","article-title":"Consensus validation of the FORTA (Fit fOR The Aged) List: A clinical tool for increasing the appropriateness of pharmacotherapy in the elderly","volume":"31","author":"Wehling","year":"2014","journal-title":"Drugs Aging"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Huiskes, V.J.B., Burger, D.M., van den Ende, C.H.M., and van den Bemt, B.J.F. (2017). Effectiveness of medication review: A systematic review and meta-analysis of randomized controlled trials. BMC Fam. Pract., 18.","DOI":"10.1186\/s12875-016-0577-x"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Bosch-Lenders, D., Jansen, J., Stoffers, H.E.J.H., Winkens, B., Aretz, K., Twellaar, M., Schols, J.M.G.A., van der Kuy, P.-H.M., Knottnerus, J.A., and van den Akker, M. (2021). The Effect of a Comprehensive Interdisciplinary Medication Review on Quality of Life and Medication Use in Community Dwelling Older People with Polypharmacy. J. Clin. Med., 10.","DOI":"10.3390\/jcm10040600"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Workgroup (2012). KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int. Suppl., 2, c179\u2013c184.","DOI":"10.1159\/000339789"},{"key":"ref_64","first-page":"17","article-title":"An Age-Calibrated Definition of Chronic Kidney Disease: Rationale and Benefits","volume":"37","author":"Delanaye","year":"2016","journal-title":"Clin. Biochem. Rev."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group (2013). KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Chapter 1: Definition and classification of CKD. Kidney Int. Suppl., 3, 19\u201362.","DOI":"10.1111\/nep.12168"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ki.2013.444","article-title":"Summary of KDIGO 2012 CKD Guideline: Behind the scenes, need for guidance, and a framework for moving forward","volume":"85","author":"Levin","year":"2014","journal-title":"Kidney Int."},{"key":"ref_67","first-page":"33","article-title":"Glomerul\u00e4re Filtrationsrate: Fallstricke der Berechnung","volume":"113","author":"Galle","year":"2016","journal-title":"Dtsch. \u00c4rztebl."},{"key":"ref_68","first-page":"849","article-title":"Renal failure\u2014measuring the glomerular filtration rate","volume":"106","author":"Thomas","year":"2009","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1093\/ndt\/gfr003","article-title":"Introduction of the CKD-EPI equation to estimate glomerular filtration rate in a Caucasian population","volume":"26","author":"Willems","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_70","first-page":"694","article-title":"The impact of the new CKD-EPI equation on GFR estimation in the elderly","volume":"119","author":"Ebert","year":"2022","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","article-title":"Chronic Kidney Disease Epidemiology Collaboration. New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race","volume":"385","author":"Inker","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJMoa2203769","article-title":"Cystatin C-based equation to estimate GFR without the inclusion of race and sex","volume":"388","author":"Pottel","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Stolpe, S., Kowall, B., Scholz, C., Stang, A., and Blume, C. (2021). High Unawareness of Chronic Kidney Disease in Germany. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182211752"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Wagner, M., Wanne, C., Schich, M., Kotseva, K., Wood, D., Hartmann, K., Fette, G., R\u00fccker, V., Oezkur, M., and St\u00f6rk, S. (2017). Patient\u2019s and physician\u2019s awareness of kidney disease in coronary heart disease patients\u2014A cross-sectional analysis of the German subset of the EUROASPIRE IV survey. BMC Nephrol., 18.","DOI":"10.1186\/s12882-017-0730-3"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/nep.13459","article-title":"Raising awareness, screening and prevention of chronic kidney disease: It takes more than a village","volume":"23","author":"Hsiao","year":"2018","journal-title":"Nephrology"},{"key":"ref_76","first-page":"513","article-title":"Knowledge and Awareness Among Patients with Chronic Kidney Disease Stage 3","volume":"43","author":"Welch","year":"2016","journal-title":"Nephrol. Nurs. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1681\/ASN.2019030238","article-title":"CKD: A Call for an Age-Adapted Definition","volume":"30","author":"Delanaye","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000272937","article-title":"Effect of chronic kidney disease and comorbid conditions on health care costs: A 10-year observational study in a general population","volume":"31","author":"Baumeister","year":"2010","journal-title":"Am. J. Nephrol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1053\/j.ackd.2019.08.001","article-title":"Nephrotoxicity of Antimicrobials and Antibiotics","volume":"27","year":"2020","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_80","first-page":"871","article-title":"Antibiotics induced acute kidney injury: Incidence, risk factors, onset time and outcome","volume":"51","author":"Khalili","year":"2013","journal-title":"Acta Med. Iran."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Cattaneo, D., Gervasoni, C., and Corona, A. (2022). The Issue of Pharmacokinetic-Driven Drug-Drug Interactions of Antibiotics: A Narrative Review. Antibiotics, 11.","DOI":"10.3390\/antibiotics11101410"},{"key":"ref_82","unstructured":"Statistisches Bundesamt (2023, January 26). Genesis Online Datenbank, Eigene Berechnung: Bev\u00f6lkerung nach Altersgruppen und Geschlecht 2021\u2014In Mio. und Anteil an der Jeweiligen Altersgruppe in %; am Jahresende. Available online: https:\/\/www.sozialpolitik-aktuell.de\/files\/sozialpolitik-aktuell\/_Politikfelder\/Bevoelkerung\/Datensammlung\/PDF-Dateien\/abbVIII3.pdf."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Li, G., Thabane, L., Papaioannou, A., Ioannidis, G., Levine, M.A., and Adachi, J.D. (2017). An overview of osteoporosis and frailty in the elderly. BMC Musculoskelet. Disord., 18.","DOI":"10.1186\/s12891-017-1403-x"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fendo.2019.00255","article-title":"Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly","volume":"10","author":"Greco","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"U.S. Preventive Services Task Force (2011). Screening for osteoporosis: U.S. preventive services task force recommendation statement. Ann. Intern. Med., 154, 356\u2013364.","DOI":"10.7326\/0003-4819-154-5-201103010-00307"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1111\/bcp.14094","article-title":"Prescribing medicines to older people-How to consider the impact of ageing on human organ and body functions","volume":"86","author":"Wilting","year":"2020","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3109\/0886022X.2014.917560","article-title":"Diuretics associated acute kidney injury: Clinical and pathological analysis","volume":"36","author":"Wu","year":"2014","journal-title":"Fail"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.2215\/CJN.01580210","article-title":"Effect of allopurinol in chronic kidney disease progression and cardiovascular risk","volume":"5","author":"Goicoechea","year":"2010","journal-title":"CJASN"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0140-6736(22)01657-9","article-title":"Allopurinol versus usual care in patients with ischaemic heart disease (ALL-HEART): A multicentre, prospective, randomised, open-label, blinded-endpoint trial","volume":"400","author":"Mackenzie","year":"2022","journal-title":"Lancet"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0140-6736(22)01778-0","article-title":"Xanthine oxidase inhibition for cardiovascular disease prevention","volume":"400","author":"Tanaka","year":"2022","journal-title":"Comment. Lancet"},{"key":"ref_91","unstructured":"(2023, February 21). Febuxostat-Ratiopharm 80 mg Filmtabletten. Fachinformation 2019. Available online: https:\/\/www.ratiopharm.de\/assets\/products\/de\/label\/Febuxostat-ratiopharm%2080%20mg%20Filmtabletten%20-%202.pdf?pzn=14168559."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jare.2017.05.001","article-title":"Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial","volume":"8","author":"Eleftheriadis","year":"2017","journal-title":"J. Adv. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1056\/NEJM199102073240605","article-title":"The nature of adverse events in hospitalized patients. Results of the Harvard Medical Practice Study II","volume":"324","author":"Leape","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s00228-010-0866-6","article-title":"Adverse drug reactions in internal medicine units and associated risk factors","volume":"66","author":"Barquilla","year":"2010","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Dicu-Andreescu, I., Penescu, M.N., C\u0103pu\u0219\u0103, C., and Verzan, C. (2022). Chronic Kidney Disease, Urinary Tract Infections and Antibiotic Nephrotoxicity: Are There Any Relationships?. Medicina, 59.","DOI":"10.3390\/medicina59010049"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3389\/fimmu.2017.00405","article-title":"Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update","volume":"8","author":"Su","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Hsiao, C.Y., Yang, H.Y., Hsiao, M.C., Hung, P.H., and Wang, M.C. (2015). Risk Factors for Development of Acute Kidney Injury in Patients with Urinary Tract Infection. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133835"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/ki.1994.298","article-title":"Coadministration of thiazides increases the efficacy of loop diuretics even in patients with advanced renal failure","volume":"46","author":"Fliser","year":"1994","journal-title":"Kidney Int."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1053\/j.ajkd.2019.07.012","article-title":"Proton Pump Inhibitors and the Kidney: Implications of Current Evidence for Clinical Practice and When and How to Deprescribe","volume":"75","author":"Maddukuri","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/ki.2014.74","article-title":"A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use","volume":"86","author":"Blank","year":"2014","journal-title":"Kidney Int."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.kint.2016.12.021","article-title":"Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury","volume":"91","author":"Xie","year":"2017","journal-title":"Kidney Int."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e8525","DOI":"10.1136\/bmj.e8525","article-title":"Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: Nested case-control study","volume":"346","author":"Lapi","year":"2013","journal-title":"BMJ"},{"key":"ref_103","unstructured":"MEDSAFE (2013). NSAIDs and acute kidney injury. MEDSAFE, 34, 14\u201315. Available online: http:\/\/medsafe.govt.nz\/profs\/PUArticles\/June2013NSAIDS.htm."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"A7","DOI":"10.1053\/j.ajkd.2019.01.001","article-title":"US Renal Data System 2018 Annual Data Report: Epidemiology of Kidney Disease in the United States","volume":"73","author":"Saran","year":"2019","journal-title":"Am J. Kidney Dis."},{"key":"ref_105","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group (2013). KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Chapter 3: Management of progression and complications of CKD. Kidney Int. Suppl., 3, 73\u201390."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5049\/EBP.2014.12.2.80","article-title":"Effect of bicarbonate supplementation on renal function and nutritional indices in predialysis advanced chronic kidney disease","volume":"12","author":"Jeong","year":"2014","journal-title":"Electrolytes Blood Press."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1159\/000339329","article-title":"Short- and long-term effects of alkali therapy in chronic kidney disease: A systematic review","volume":"35","author":"Susantitaphong","year":"2012","journal-title":"Am. J. Nephrol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/nep.12942","article-title":"Acute kidney injury post-major orthopaedic surgery: A single-Centre case-control study","volume":"23","author":"Ying","year":"2018","journal-title":"Nephrology"},{"key":"ref_109","first-page":"743","article-title":"Drug-induced nephrotoxicity","volume":"78","author":"Naughton","year":"2008","journal-title":"Am. Fam. Physician"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"996042","DOI":"10.3389\/fphar.2022.996042","article-title":"A focus on CKD reporting and inappropriate prescribing among older patients discharged from geriatric and nephrology units throughout Italy: A nationwide multicenter retrospective cross-sectional study","volume":"13","author":"Aucella","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s40266-018-0554-2","article-title":"International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action","volume":"35","author":"Mangin","year":"2018","journal-title":"Drugs Aging"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.semnephrol.2016.05.005","article-title":"The Role of Acute Kidney Injury in Chronic Kidney Disease","volume":"36","author":"Hsu","year":"2016","journal-title":"Semin. Nephrol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ccc.2016.12.008","article-title":"Perioperative acute kidney injury","volume":"33","author":"Hobson","year":"2017","journal-title":"Crit. Care Clin."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000490500","article-title":"Perioperative Acute Kidney Injury: Prevention, Early Recognition, and Supportive Measures","volume":"140","author":"Romagnoli","year":"2018","journal-title":"Nephron"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bja.2020.06.064","article-title":"Pharmacological interventions for the prevention of renal injury in surgical patients: A systematic literature review and meta-analysis","volume":"126","author":"Pathak","year":"2021","journal-title":"Br. J. Anaesth."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Gameiro, J., Fonseca, J.A., Outerelo, C., and Lopes, J.A. (2020). Acute Kidney Injury: From Diagnosis to Prevention and Treatment Strategies. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061704"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1056\/NEJMra1214243","article-title":"Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes","volume":"371","author":"Chawla","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2047-0525-1-6","article-title":"Perioperative acute kidney injury","volume":"1","author":"Calvert","year":"2012","journal-title":"Perioper Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2215\/CJN.00220605","article-title":"Epidemiology and outcomes of acute renal failure in hospitalized patients: A national survey","volume":"1","author":"Liangos","year":"2006","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1056\/NEJM199102073240604","article-title":"Incidence of adverse events and negligence in hospitalized patients. Results of the Harvard Medical Practice Study I","volume":"324","author":"Brennan","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5414\/CN109212","article-title":"Drug-induced kidney injury: A large case series from the Berlin Case-Control Surveillance Study","volume":"89","author":"Douros","year":"2018","journal-title":"Clin. Nephrol."},{"key":"ref_122","first-page":"f880","article-title":"Use of high potency statins and rates of admission for acute kidney injury: Multicenter, retrospective observational analysis of administrative databases","volume":"346","author":"Dormuth","year":"2013","journal-title":"BMJ (Clin. Res. Ed.)"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/eb-2013-101357","article-title":"High-potency statins are associated with increased hospitalisations with acute kidney injury","volume":"19","author":"Keys","year":"2014","journal-title":"Evid.-Based Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.ekir.2022.04.094","article-title":"Prescribing SGLT2 Inhibitors in Patients With CKD: Expanding Indications and Practical Considerations","volume":"7","author":"Yau","year":"2022","journal-title":"Kidney Int. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1093\/ndt\/gfaa234","article-title":"The dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) trial: Baseline characteristics","volume":"35","author":"Wheeler","year":"2020","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00228-007-0422-1","article-title":"The clinical implications of ageing for rational drug therapy","volume":"64","author":"Shi","year":"2008","journal-title":"Eur. J. Clin. 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