{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:44:29Z","timestamp":1790790269357,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pfizer","award":["Global Medical Grant 64911533"],"award-info":[{"award-number":["Global Medical Grant 64911533"]}]},{"name":"the Philipp Schwartz Initiative","award":["Global Medical Grant 64911533"],"award-info":[{"award-number":["Global Medical Grant 64911533"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Wild-type transthyretin amyloid cardiomyopathy (wtATTR-CM) is characterized by heart failure, conduction abnormalities and arrhythmias. The incidence of ventricular arrhythmias, particularly ventricular tachycardias (VTs), in wtATTR-CM is unclear. With the development of targeted therapies and improved overall prognosis, there is an unmet need to identify patients at high risk for VTs who might benefit from ICD therapy. Methods: Between 2017 and 2022, 72 patients diagnosed with wtATTR-CM were prospectively evaluated for the presence of ventricular arrhythmias using a Holter ECG. VTs were defined as &gt;3 consecutive beats with a heart rate &gt; 100 beats per minute originating from a ventricle. Results: The incidence of VTs was 44% (n = 32\/72) in unselected wtATTR-CM patients. Patients with VT showed significantly more severe left ventricular (LV) hypertrophy (septum diameter 21 \u00b1 2.6 vs. 19 \u00b1 3.0 mm, p = 0.006), reduced LV ejection fraction (47 \u00b1 8 vs. 52 \u00b1 8%, p = 0.014) and larger left atria (32 \u00b1 7 vs. 28 \u00b1 6 mm2, p = 0.020), but no differences in cardiac markers such as NTproBNP and troponin. In a multivariable model, LV hypertrophy (LV mass indexed, OR = 1.02 [1.00\u20131.03], p = 0.031), LV end-diastolic diameter (OR = 0.85 [0.74\u20130.98], p = 0.021) and LV end-systolic diameter (OR = 1.19 [1.03\u20131.349], p = 0.092) were predictive for VT occurrence with an area under the receiver operating characteristic of 0.76 [0.65\u20130.87]. Conclusions: The incidence of ventricular arrhythmia in wtATTR-CM is high and is associated with an advanced stage of left ventricular disease. Further studies are needed evaluating the role of VTs in predicting sudden cardiac death and the benefit of ICD therapy in wtATTR-CM.<\/jats:p>","DOI":"10.3390\/jcm12144624","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T01:01:41Z","timestamp":1689123701000},"page":"4624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Incidence and Predictors of Ventricular Arrhythmias in Transthyretin Amyloid Cardiomyopathy"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2339-591X","authenticated-orcid":false,"given":"Katharina","family":"Knoll","sequence":"first","affiliation":[{"name":"German Heart Centre Munich, Department of Cardiology, Technical University of Munich, 80333 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Fuchs","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Cardiology, Technical University of Munich, 80333 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Weidmann","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Cardiology, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Altunkas","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Cardiology, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Voss","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Cardiovascular Surgery, Technical University of Munich, 80636 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Lennerz","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Cardiology, Technical University of Munich, 80333 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Kolb","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Cardiology, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Kessler","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Cardiology, Technical University of Munich, 80333 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-3001","authenticated-orcid":false,"given":"Heribert","family":"Schunkert","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Cardiology, Technical University of Munich, 80333 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wibke","family":"Reinhard","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Cardiology, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-7161","authenticated-orcid":false,"given":"Stefan","family":"Gro\u00df","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, 17475 Greifswald, Germany"},{"name":"Department of Internal Medicine B, University Medicine Greifswald, 17475 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Trenkwalder","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Cardiology, Technical University of Munich, 80333 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1161\/CIR.0000000000000792","article-title":"Cardiac Amyloidosis: Evolving Diagnosis and Management: A Scientific Statement From the American Heart Association","volume":"142","author":"Kittleson","year":"2020","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/eurheartj\/ehv338","article-title":"Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction","volume":"36","author":"Robles","year":"2015","journal-title":"Eur. 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