{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:58:34Z","timestamp":1780617514810,"version":"3.54.1"},"reference-count":29,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The aim of this study was to analyze the mortality of polytrauma patients and identify prediction parameters. A further aim was to create from the results a score for the prehospital predictive evaluation of 30-day survival. The study was conducted with a retrospective, observational design and was carried out unicentrically at a Level 1 Trauma Center. During the 4-year investigation period, patients with an Injury Severity Score (ISS) \u2265 16 were examined and their demographic basic data, laboratory values, and vital parameters were recorded. The mortality data analysis was performed using Kaplan\u2013Meier Analysis and Log-Rank tests. Cox regressions were carried out to determine influencing factors and Receiver Operating Characteristic (ROC) curves were plotted to establish limit values for potential influencing factors. All statistical tests were conducted at a significance level of p \u2264 0.05. Coronary Heart Disease (CHD), cardiopulmonary resuscitation (CPR), age at admission, sex, and Glasgow Coma Scale (GCS) had a significant impact on the survival of polytrauma patients. The identified prediction parameters were combined with the shock index (SI). The generated score showed a sensitivity of 93.1% and a specificity of 73.3% in predicting the mortality risk. The study was able to identify significant influencing prehospital risk factors on 30-day survival after polytrauma. A score created from these parameters showed higher specificity and sensitivity than other prediction scores. Further studies with a larger number of participants and the inclusion of slightly injured patients could verify these findings.<\/jats:p>","DOI":"10.3390\/jcm12144724","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T01:46:02Z","timestamp":1689644762000},"page":"4724","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mortality Risk Factors of Severely Injured Polytrauma Patients (Prehospital Mortality Prediction Score)"],"prefix":"10.3390","volume":"12","author":[{"given":"Jana","family":"Vorbeck","sequence":"first","affiliation":[{"name":"Surgical Clinic II, Aschaffenburg-Alzenau Hospital, 63739 Aschaffenburg, Germany"},{"name":"Department of Trauma, Hand, and Reconstructive Surgery, University Hospital M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Surgical Clinic II, Aschaffenburg-Alzenau Hospital, 63739 Aschaffenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"D\u00fcsing","sequence":"additional","affiliation":[{"name":"Department of Trauma, Hand, and Reconstructive Surgery, University Hospital M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6175-2754","authenticated-orcid":false,"given":"Ren\u00e9","family":"Hartensuer","sequence":"additional","affiliation":[{"name":"Surgical Clinic II, Aschaffenburg-Alzenau Hospital, 63739 Aschaffenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s00268-013-2294-0","article-title":"Educational and clinical impact of Advanced Trauma Life Support (ATLS) courses: A systematic review","volume":"38","author":"Mohammad","year":"2014","journal-title":"World J. Surg."},{"key":"ref_2","first-page":"29","article-title":"Venous glucose, serum lactate and base deficit as biochemical predictors of mortality in patients with polytrauma","volume":"22","author":"Saad","year":"2016","journal-title":"Ulus. Travma Ve Acil Cerrahi Derg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Qi, J., Bao, L., Yang, P., and Chen, D. (2021). Comparison of base excess, lactate and pH predicting 72-h mortality of multiple trauma. BMC Emerg. Med., 21.","DOI":"10.1186\/s12873-021-00465-9"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.afjem.2013.11.006","article-title":"Lactate clearance predicts outcome after major trauma","volume":"4","author":"Heinonen","year":"2014","journal-title":"Afr. J. Emerg. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/SHK.0000000000001066","article-title":"Association of Clinical Hypoperfusion Variables with Lactate Clearance and Hospital Mortality","volume":"50","author":"Morales","year":"2018","journal-title":"Shock"},{"key":"ref_6","first-page":"277","article-title":"Predictive value of prognostic factors at multiple trauma patients in intensive care admission","volume":"122","author":"Atik","year":"2021","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1590\/S0102-67202015000300004","article-title":"Lactate as Predictor of Mortality in Polytrauma","volume":"28","author":"Freitas","year":"2015","journal-title":"ABCD Arq. Bras. De Cir. Dig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.5505\/tjtes.2011.76158","article-title":"Factors affecting mortality in patients with thorax trauma","volume":"17","author":"Emircan","year":"2011","journal-title":"Ulus. Travma Ve Acil Cerrahi Derg."},{"key":"ref_9","first-page":"156","article-title":"The geriatric polytrauma: Risk profile and prognostic factors","volume":"23","author":"Rupprecht","year":"2016","journal-title":"Ulus. Travma Ve Acil Cerrahi Derg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.6061\/clinics\/2017(08)02","article-title":"Independent early predictors of mortality in polytrauma patients: A prospective, observational, longitudinal study","volume":"72","author":"Carmona","year":"2017","journal-title":"Clinics"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Samuthtai, W., Patumanond, J., Samutrtai, P., Charernboon, T., Jearwattanakanok, K., and Khorana, J. (2022). Clinical Prediction Scoring Scheme for 24 h Mortality in Major Traumatic Adult Patients. Healthcare, 10.","DOI":"10.3390\/healthcare10030577"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.injury.2016.02.027","article-title":"Factors affecting mortality in older trauma patients\u2014A systematic review and meta-analysis","volume":"47","author":"Sammy","year":"2016","journal-title":"Injury"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00005373-197403000-00001","article-title":"The injury severity score: A method for describing patients with multiple injuries and evaluating emergency care","volume":"14","author":"Baker","year":"1974","journal-title":"J. Trauma"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/00003246-198109000-00015","article-title":"Trauma score","volume":"9","author":"Champion","year":"1981","journal-title":"Crit. Care Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/00005373-198704000-00005","article-title":"Evaluating trauma care: The TRISS method. Trauma Score and the Injury Severity Score","volume":"27","author":"Boyd","year":"1987","journal-title":"J. Trauma"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1365-2796.2004.01321.x","article-title":"Rapid Emergency Medicine score: A new prognostic tool for in-hospital mortality in nonsurgical emergency department patients","volume":"255","author":"Olsson","year":"2004","journal-title":"J. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: A severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit. Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1186\/s13054-014-0476-2","article-title":"Update of the trauma risk adjustment model of the TraumaRegister DGU\u2122: The Revised Injury Severity Classification, version II","volume":"18","author":"Lefering","year":"2014","journal-title":"Crit. Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e000131","DOI":"10.1136\/tsaco-2017-000131","article-title":"Trauma Early Mortality Prediction Tool (TEMPT) for assessing 28-day mortality","volume":"3","author":"Kunitake","year":"2018","journal-title":"Trauma Surg. Acute Care Open"},{"key":"ref_20","unstructured":"IBM (2013). SPSS Statistics for Windows, IBM Corporation. Available online: https:\/\/www.ibm.com\/support\/pages\/spss-statistics-220-available-download."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13049-016-0295-3","article-title":"Evaluation of a trauma team activation protocol revision: A prospective cohort study","volume":"24","author":"Dehli","year":"2016","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_22","unstructured":"Bieler, D. (2022). Polytrauma\/Schwerverletzten-Behandlung: S3-Leitlinie, der Deutschen Gesellschaft f\u00fcr Unfallchirurgie e.V."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Cleophas, T.J., and Zwinderman, A.H. (2017). Understanding Clinical Data Analysis, Springer International Publishing.","DOI":"10.1007\/978-3-319-39586-9"},{"key":"ref_24","first-page":"746","article-title":"An introduction to multiplicity issues in clinical trials: The what, why, when and how","volume":"46","author":"Li","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00068-020-01410-4","article-title":"ISS alone, is not sufficient to correctly assign patients post hoc to trauma team requirement","volume":"48","author":"Waydhas","year":"2022","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Fitschen-Oestern, S., Lippross, S., Lefering, R., Kl\u00fcter, T., Weuster, M., Franke, G.M., Kirsten, N., M\u00fcller, M., Schr\u00f6der, O., and Seekamp, A. (2021). Does the time of the day affect multiple trauma care in hospitals? A retrospective analysis of data from the TraumaRegister DGU\u00ae. BMC Emerg. Med., 21.","DOI":"10.1186\/s12873-021-00525-0"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s00068-019-01285-0","article-title":"Do elderly trauma patients receive the required treatment? Epidemiology and outcome of geriatric trauma patients treated at different levels of trauma care","volume":"46","author":"Caspers","year":"2020","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.injury.2018.09.051","article-title":"Impact of body mass index on outcomes after thoracic trauma\u2014A matched-triplet analysis of the TraumaRegister DGU\u00ae","volume":"50","author":"Schieren","year":"2019","journal-title":"Injury"},{"key":"ref_29","unstructured":"H\u00f6fer, C., and Lefering, R. (2022). Jahresbericht 2022\u2014TraumaRegister DGU\u00ae: F\u00fcr das Unfalljahr 2021, TraumaRegister DGU\u00ae."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/14\/4724\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:13:15Z","timestamp":1760127195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/14\/4724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,17]]},"references-count":29,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["jcm12144724"],"URL":"https:\/\/doi.org\/10.3390\/jcm12144724","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,17]]}}}