{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:57:59Z","timestamp":1785423479754,"version":"3.56.0"},"reference-count":62,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australian National Health and Medical Research (NHMRC) Senior Practitioner Fellowship","award":["1154302"],"award-info":[{"award-number":["1154302"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>In children and adults, chronic cough is a common symptom presenting to health professionals worldwide. It is internationally accepted that children with chronic cough should be managed with pediatric specific management guidelines. The newly proposed clinical entity of \u2018cough hypersensitivity syndrome\u2019 has gained significant attention in adult literature. Given the significant differences between childhood and adult chronic cough, including in respiratory physiology and anatomy, and cough sensitivity, we address the suitability of the use of cough hypersensitivity syndrome in children. We explore these differences between childhood and adult chronic cough, explain what cough hypersensitivity is and highlight why the term cough hypersensitivity syndrome should not be used in children.<\/jats:p>","DOI":"10.3390\/jcm12154879","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:32:10Z","timestamp":1690248730000},"page":"4879","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cough Hypersensitivity Syndrome: Why Its Use Is Inappropriate in Children"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1331-3706","authenticated-orcid":false,"given":"Anne B.","family":"Chang","sequence":"first","affiliation":[{"name":"Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia"},{"name":"Department of Respiratory and Sleep Medicine, Queensland Children\u2019s Hospital, Brisbane, QLD 4101, Australia"},{"name":"NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, UMass Memorial Medical Center, Worcester, MA 01605, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E.","family":"O\u2019Farrell","sequence":"additional","affiliation":[{"name":"Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia"},{"name":"NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter V.","family":"Dicpinigaitis","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhani","family":"Goel","sequence":"additional","affiliation":[{"name":"Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia"},{"name":"Somerville House, South Brisbane, QLD 4101, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3445-4612","authenticated-orcid":false,"given":"Ahmad","family":"Kantar","sequence":"additional","affiliation":[{"name":"Pediatric Asthma and Cough Centre, Istituti Ospedalieri Bergamaschi, University and Research Hospitals, via Forlanini 15, Ponte San Pietro-Bergamo, 24036 Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-1829","authenticated-orcid":false,"given":"Julie M.","family":"Marchant","sequence":"additional","affiliation":[{"name":"Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia"},{"name":"Department of Respiratory and Sleep Medicine, Queensland Children\u2019s Hospital, Brisbane, QLD 4101, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1378\/chest.14-1485","article-title":"Overview of the management of cough: CHEST Guideline and Expert Panel Report","volume":"146","author":"Irwin","year":"2014","journal-title":"Chest"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1378\/chest.11-2725","article-title":"A multi-centre study on chronic cough in children: Burden and etiologies based on a standardized management pathway","volume":"142","author":"Chang","year":"2012","journal-title":"Chest"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1378\/chest.10-1476","article-title":"Minimally important change in a parent-proxy quality of life questionnaire for pediatric chronic cough (PC-QOL)","volume":"139","author":"Newcombe","year":"2010","journal-title":"Chest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1136\/thoraxjnl-2015-207473","article-title":"A child chronic cough-specific quality of life measure: Development and validation","volume":"71","author":"Newcombe","year":"2016","journal-title":"Thorax"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1136\/archdischild-2017-312848","article-title":"Chronic cough postacute respiratory illness in children: A cohort study","volume":"102","author":"Drescher","year":"2017","journal-title":"Arch. 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