{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:40:48Z","timestamp":1791567648797,"version":"4.3.4"},"reference-count":33,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Access Publication Fund of the University of Freiburg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The XEN\u00ae gel stent reduces intraocular pressure (IOP) in glaucoma. XEN\u00ae-45 is widely used; the newer XEN\u00ae-63 has a larger lumen targeting potentially lower IOP outcomes. We retrospectively compared the first 15 XEN\u00ae-63 cases to 15 matched XEN\u00ae-45 controls. With a preoperative IOP of 18.1 \u00b1 3.9 mmHg (mean \u00b1 SD) and a final IOP of 9.1 \u00b1 2.0 mmHg, XEN\u00ae-63 implantation resulted in an IOP reduction of 44.6 \u00b1 16.5%. Similarly, with a preoperative IOP of 18.3 \u00b1 4.5 mmHg and a final IOP of 10.3 \u00b1 2.1 mmHg, XEN\u00ae-45 implantation resulted in an IOP reduction of 40.1 \u00b1 17.2%. The median follow-up period was 204 days (range 78\u2013338 days) for the XEN\u00ae-63 group and 386 days (range 99\u20131688 days) for the XEN\u00ae-45 group. In total, 5\/15 eyes of each group underwent open conjunctival bleb revision within the period of observation. Three eyes of the XEN\u00ae-63 group had secondary glaucoma surgery. One eye in the XEN\u00ae-63 group and three eyes in the XEN\u00ae-45 group required a restart of antiglaucomatous medication. In conclusion, both stents effectively lower IOP and medication. XEN\u00ae-63 achieved a slightly lower IOP over a short follow-up. Complication and revision rates were similar.<\/jats:p>","DOI":"10.3390\/jcm12155043","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:00:15Z","timestamp":1690797615000},"page":"5043","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["XEN\u00ae-63 Compared to XEN\u00ae-45 Gel Stents to Reduce Intraocular Pressure in Glaucoma"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9625-0298","authenticated-orcid":false,"given":"Charlotte","family":"Evers","sequence":"first","affiliation":[{"name":"Eye Center, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"B\u00f6hringer","sequence":"additional","affiliation":[{"name":"Eye Center, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Kallee","sequence":"additional","affiliation":[{"name":"Eye Center, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-5267","authenticated-orcid":false,"given":"Philip","family":"Keye","sequence":"additional","affiliation":[{"name":"Eye Center, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5380-6994","authenticated-orcid":false,"given":"Heiko","family":"Philippin","sequence":"additional","affiliation":[{"name":"Eye Center, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"},{"name":"International Centre for Eye Health, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Piotrowski","sequence":"additional","affiliation":[{"name":"Eye Center, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Eye Center, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"L\u00fcbke","sequence":"additional","affiliation":[{"name":"Eye Center, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jcrs.2014.01.032","article-title":"Ab Interno Approach to the Subconjunctival Space Using a Collagen Glaucoma Stent","volume":"40","author":"Lewis","year":"2014","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hengerer, F.H., Auffarth, G.U., Yildirim, T.M., and Conrad-Hengerer, I. (2018). Ab Interno Gel Implant in Patients with Primary Open Angle Glaucoma and Pseudoexfoliation Glaucoma. BMC Ophthalmol., 18.","DOI":"10.1186\/s12886-018-0989-6"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/IJG.0000000000001045","article-title":"Prospective Evaluation of XEN Gel Implant in Eyes with Pseudoexfoliative Glaucoma","volume":"27","author":"Mansouri","year":"2018","journal-title":"J. Glaucoma"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00417-018-3899-7","article-title":"The XEN45 Gel Stent as a Minimally Invasive Procedure in Glaucoma Surgery: Success Rates, Risk Profile, and Rates of Re-Surgery after 261 Surgeries","volume":"256","author":"Widder","year":"2018","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/ceo.13087","article-title":"XEN-45 Collagen Implant for the Treatment of Uveitic Glaucoma","volume":"46","author":"Sng","year":"2018","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/IJG.0000000000001389","article-title":"Urgent Management of Secondary Glaucoma in Uveitis Using the Xen-45 Gel Stent","volume":"28","author":"Qureshi","year":"2019","journal-title":"J. Glaucoma"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Schargus, M., Theilig, T., Rehak, M., Busch, C., Bormann, C., and Unterlauft, J.D. (2020). Outcome of a Single XEN Microstent Implant for Glaucoma Patients with Different Types of Glaucoma. BMC Ophthalmol., 20.","DOI":"10.1186\/s12886-020-01764-8"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s00417-019-04341-y","article-title":"XEN Implant Device versus Trabeculectomy, Either Alone or in Combination with Phacoemulsification, in Open-Angle Glaucoma Patients","volume":"257","author":"Ceausescu","year":"2019","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5457246","DOI":"10.1155\/2017\/5457246","article-title":"XEN Glaucoma Implant with Mitomycin C 1-Year Follow-Up: Result and Complications","volume":"2017","author":"Galal","year":"2017","journal-title":"J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s00417-019-04251-z","article-title":"Apex Study Group Two-Year Results of a Multicenter Study of the Ab Interno Gelatin Implant in Medically Uncontrolled Primary Open-Angle Glaucoma","volume":"257","author":"Reitsamer","year":"2019","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.1111\/aos.14886","article-title":"Three-Year Effectiveness and Safety of the XEN Gel Stent as a Solo Procedure or in Combination with Phacoemulsification in Open-Angle Glaucoma: A Multicentre Study","volume":"100","author":"Reitsamer","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.ophtha.2017.05.004","article-title":"Efficacy, Safety, and Risk Factors for Failure of Standalone Ab Interno Gelatin Microstent Implantation versus Standalone Trabeculectomy","volume":"124","author":"Schlenker","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/eye.2017.162","article-title":"One-Year Result of XEN45 Implant for Glaucoma: Efficacy, Safety, and Postoperative Management","volume":"32","author":"Tan","year":"2018","journal-title":"Eye"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/IJG.0000000000002090","article-title":"3-Year Outcomes of XEN Implant Compared with Trabeculectomy, with or without Phacoemulsification for Open Angle Glaucoma","volume":"31","year":"2022","journal-title":"J. Glaucoma"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Poelman, H.J., Pals, J., Rostamzad, P., Bramer, W.M., Wolfs, R.C.W., and Ramdas, W.D. (2021). Efficacy of the XEN-Implant in Glaucoma and a Meta-Analysis of the Literature. J. Clin. Med., 10.","DOI":"10.3390\/jcm10051118"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.jcrs.2015.01.019","article-title":"Phacoemulsification Combined with a New Ab Interno Gel Stent to Treat Open-Angle Glaucoma: Pilot Study","volume":"41","author":"Sheybani","year":"2015","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/ceo.13463","article-title":"Four-Year Results of a Minimally Invasive Transscleral Glaucoma Gel Stent Implantation in a Prospective Multi-Centre Study","volume":"47","author":"Lenzhofer","year":"2019","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1177\/1120672120952033","article-title":"XEN 63 Gel Stent Device in Glaucoma Surgery: A 5-Years Follow-up Prospective Study","volume":"31","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Fea, A.M., Menchini, M., Rossi, A., Posarelli, C., Malinverni, L., and Figus, M. (2021). Early Experience with the New XEN63 Implant in Primary Open-Angle Glaucoma Patients: Clinical Outcomes. J. Clin. Med., 10.","DOI":"10.3390\/jcm10081628"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fea, A.M., Menchini, M., Rossi, A., Posarelli, C., Malinverni, L., and Figus, M. (2022). Outcomes of XEN 63 Device at 18-Month Follow-Up in Glaucoma Patients: A Two-Center Retrospective Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11133801"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Hussien, I.M., De Francesco, T., and Ahmed, I.I.K. (2023). Intermediate Outcomes of the Novel 63 \u03bcm Gelatin Microstent versus the Conventional 45\u03bcm Gelatin Microstent. Ophthalmol. Glaucoma, in press.","DOI":"10.1016\/j.ogla.2023.05.001"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.1097\/IJG.0000000000000795","article-title":"Suprachoroidal Bleeding After XEN Gel Implantation","volume":"26","author":"Vossmerbaeumer","year":"2017","journal-title":"J. Glaucoma"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100600","DOI":"10.1016\/j.ajoc.2020.100600","article-title":"Intraoperative Suprachoroidal Hemorrhage during Xen Gel Stent Implantation","volume":"17","author":"Liu","year":"2020","journal-title":"Am. J. Ophthalmol. Case Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"132","DOI":"10.5005\/jp-journals-10078-1378","article-title":"Suprachoroidal Hemorrhage after XEN Gel Implant Requiring Surgical Drainage","volume":"16","author":"Wang","year":"2022","journal-title":"J. Curr. Glaucoma Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1097\/IJG.0000000000001929","article-title":"Open Conjunctival Approach for Sub-Tenon\u2019s Xen Gel Stent Placement and Bleb Morphology by Anterior Segment Optical Coherence Tomography","volume":"30","author":"Dangda","year":"2021","journal-title":"J. Glaucoma"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ogla.2020.12.003","article-title":"Comparison of Clinical Outcomes with Open Versus Closed Conjunctiva Implantation of the XEN45 Gel Stent","volume":"4","author":"Do","year":"2021","journal-title":"Ophthalmol. Glaucoma"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/s41433-021-01635-6","article-title":"Outcomes of XEN45 Gel Stent Using Posterior Small Incision Sub-Tenon Ab Interno Insertion (Semi-Open) Technique","volume":"36","author":"Kong","year":"2022","journal-title":"Eye"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s40123-020-00234-0","article-title":"Technique of Xen Implant Revision Surgery and the Surgical Outcomes: A Retrospective Interventional Case Series","volume":"9","author":"Linton","year":"2020","journal-title":"Ophthalmol. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/IJG.0000000000001394","article-title":"Efficacy of Needling Revision After XEN Gel Stent Implantation: A Prospective Study","volume":"29","author":"Midha","year":"2020","journal-title":"J. Glaucoma"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1177\/1120672120963447","article-title":"Needling after XEN Gel Implant: What\u2019s the Efficacy? A 1-Year Analysis","volume":"31","author":"Teixeira","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1177\/11206721211012847","article-title":"XEN45 Real-Life Evaluation: Survival Analysis with Bleb Needling and Major Revision Outcomes","volume":"32","author":"Pazos","year":"2022","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1007\/s00417-021-05204-1","article-title":"Needling and Open Filtering Bleb Revision after XEN-45 Implantation-a Retrospective Outcome Comparison","volume":"259","author":"Steiner","year":"2021","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_33","first-page":"4796548","article-title":"Comparing Medium-Term Clinical Outcomes Following XEN\u00ae 45 and XEN\u00ae 63 Device Implantation","volume":"2020","author":"Zhou","year":"2020","journal-title":"J. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/15\/5043\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:23:20Z","timestamp":1760127800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/15\/5043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":33,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["jcm12155043"],"URL":"https:\/\/doi.org\/10.3390\/jcm12155043","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,31]]}}}