{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:44:42Z","timestamp":1771508682559,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Farhat Hached University Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: An alarming number of COVID-19 patients, especially in severe cases, have developed acute kidney injury (AKI). Aim: The study aimed to assess the frequency, risk factors, and impact of AKI on mortality in critically ill COVID-19 patients. Methods: The study was a retrospective observational study conducted in the MICU. Univariate and multivariate analyses were performed to identify risk factors for AKI and clinical outcomes. Results: During the study period, 465 consecutive COVID-19 patients were admitted to the MICU. The patients\u2019 characteristics were median age, 64 [54\u201371] years; median SAPSII, 31 [24\u201338]; and invasive mechanical ventilation (IMV), 244 (52.5%). The overall ICU mortality rate was 49%. Two hundred twenty-nine (49.2%) patients developed AKI. The factors independently associated with AKI were positive fluid balance (OR, 2.78; 95%CI [1.88\u20134.11]; p &lt; 0.001), right heart failure (OR, 2.15; 95%CI [1.25\u20133.67]; p = 0.005), and IMV use (OR, 1.55; 95%CI [1.01\u20132.40]; p = 0.044). Among the AKI patients, multivariate analysis identified the following factors as independently associated with ICU mortality: age (OR, 1.05; 95%CI [1.02\u20131.09]; p = 0.012), IMV use (OR, 48.23; 95%CI [18.05\u2013128.89]; p &lt; 0.001), and septic shock (OR, 3.65; 95%CI [1.32\u201310.10]; p = 0.012). Conclusion: The present study revealed a high proportion of AKI among critically ill COVID-19 patients. This complication seems to be linked to a severe cardiopulmonary interaction and fluid balance management, thus accounting for a poor outcome.<\/jats:p>","DOI":"10.3390\/jcm12155127","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T09:28:29Z","timestamp":1691141309000},"page":"5127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Features and Outcomes of Acute Kidney Injury in Critically Ill COVID-19 Patients: A Retrospective Observational Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2108-5181","authenticated-orcid":false,"given":"Nabil","family":"Bouguezzi","sequence":"first","affiliation":[{"name":"Faculty of Medicine of Sousse, University of Sousse, Sousse 4000, Tunisia"},{"name":"Medical Intensive Care Unit, Research Laboratory \u201cHeart Failure\u201d, LR12SP09, Farhat Hached University Hospital, Sousse 4000, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8698-9339","authenticated-orcid":false,"given":"Imen","family":"Ben Saida","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Sousse, University of Sousse, Sousse 4000, Tunisia"},{"name":"Medical Intensive Care Unit, Research Laboratory \u201cHeart Failure\u201d, LR12SP09, Farhat Hached University Hospital, Sousse 4000, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0775-8562","authenticated-orcid":false,"given":"Radhouane","family":"Toumi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Sousse, University of Sousse, Sousse 4000, Tunisia"},{"name":"Medical Intensive Care Unit, Research Laboratory \u201cHeart Failure\u201d, LR12SP09, Farhat Hached University Hospital, Sousse 4000, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaoula","family":"Meddeb","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Sousse, University of Sousse, Sousse 4000, Tunisia"},{"name":"Medical Intensive Care Unit, Research Laboratory \u201cHeart Failure\u201d, LR12SP09, Farhat Hached University Hospital, Sousse 4000, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emna","family":"Ennouri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Sousse, University of Sousse, Sousse 4000, Tunisia"},{"name":"Medical Intensive Care Unit, Research Laboratory \u201cHeart Failure\u201d, LR12SP09, Farhat Hached University Hospital, Sousse 4000, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7762-5525","authenticated-orcid":false,"given":"Amir","family":"Bedhiafi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Sousse, University of Sousse, Sousse 4000, Tunisia"},{"name":"Medical Intensive Care Unit, Research Laboratory \u201cHeart Failure\u201d, LR12SP09, Farhat Hached University Hospital, Sousse 4000, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhouha","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Sousse, University of Sousse, Sousse 4000, Tunisia"},{"name":"Medical Intensive Care Unit, Research Laboratory \u201cHeart Failure\u201d, LR12SP09, Farhat Hached University Hospital, Sousse 4000, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-2156","authenticated-orcid":false,"given":"Mohamed","family":"Boussarsar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Sousse, University of Sousse, Sousse 4000, Tunisia"},{"name":"Medical Intensive Care Unit, Research Laboratory \u201cHeart Failure\u201d, LR12SP09, Farhat Hached University Hospital, Sousse 4000, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"ref_1","unstructured":"(2022, July 29). 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