{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T18:06:34Z","timestamp":1764785194845,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Stevens\u2013Johnson syndrome (SJS) and the more severe variant, toxic epidermal necrolysis (TEN), are a spectrum of mucocutaneous reactions with potentially devastating ocular consequences. Ocular complications occur in about 70% of patients with Stevens\u2013Johnson syndrome, and 35% continue with chronic disease. We report an unusual presentation of isolated ocular Stevens\u2013Johnson syndrome in a patient with recently diagnosed ulcerative colitis being treated with Infliximab. The case had an insidious and atypical onset and represented a diagnostic dilemma. The diagnosis was more difficult, due to the fact that the inciting agent had long been stopped. Severe bacterial conjunctivitis such as that caused by Chlamydia Trachomatis, Corynebacterium diphtheria, and Neisseria Gonorrhea can cause forniceal shortening and symblepharon; this diagnosis was ruled out with microbiological swabs. A conjunctival biopsy was the key to diagnosis. Treatment involved high-dose IV steroids and dual immunosuppression with Infliximab and mycophenolate mofetil. We sought to employ interventions with the greatest impacts on our patient\u2019s condition. Our experience contributes to the growing evidence supporting intensive ophthalmic management of SJS to prevent long-term vision loss.<\/jats:p>","DOI":"10.3390\/jcm12165259","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T10:40:31Z","timestamp":1692009631000},"page":"5259","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Isolated Ocular Stevens\u2013Johnson Syndrome Caused by Lymecycline in a Patient with Underlying Ulcerative Colitis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-1675","authenticated-orcid":false,"given":"Christine M.","family":"Bourke","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Children\u2019s Health Ireland at Crumlin, Cooley Road, Crumlin, D12 N512 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6367-2195","authenticated-orcid":false,"given":"Brendan K.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Adelaide Road, D02 XK51 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-2866","authenticated-orcid":false,"given":"Daire J.","family":"Hurley","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Adelaide Road, D02 XK51 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conor C.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Adelaide Road, D02 XK51 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Chamney","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Children\u2019s Health Ireland at Crumlin, Cooley Road, Crumlin, D12 N512 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1056\/NEJM199411103311906","article-title":"Severe Adverse Cutaneous Reactions to Drugs","volume":"331","author":"Roujeau","year":"1994","journal-title":"N. 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