{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T02:51:06Z","timestamp":1775703066926,"version":"3.50.1"},"reference-count":151,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EU Horizon 2020 FETOPEN-2018\u20132020 Program","award":["828984"],"award-info":[{"award-number":["828984"]}]},{"name":"EU Horizon 2020 FETOPEN-2018\u20132020 Program","award":["CVU121216"],"award-info":[{"award-number":["CVU121216"]}]},{"name":"Italian Ministry of Education, University, and Research","award":["828984"],"award-info":[{"award-number":["828984"]}]},{"name":"Italian Ministry of Education, University, and Research","award":["CVU121216"],"award-info":[{"award-number":["CVU121216"]}]},{"name":"University of Pavia","award":["828984"],"award-info":[{"award-number":["828984"]}]},{"name":"University of Pavia","award":["CVU121216"],"award-info":[{"award-number":["CVU121216"]}]},{"name":"National Council of Science and Technology (CONACYT)","award":["828984"],"award-info":[{"award-number":["828984"]}]},{"name":"National Council of Science and Technology (CONACYT)","award":["CVU121216"],"award-info":[{"award-number":["CVU121216"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder that may lead patients to sudden cell death through the occurrence of ventricular arrhythmias. ACM is characterised by the progressive substitution of cardiomyocytes with fibrofatty scar tissue that predisposes the heart to life-threatening arrhythmic events. Cardiac mesenchymal stromal cells (C-MSCs) contribute to the ACM by differentiating into fibroblasts and adipocytes, thereby supporting aberrant remodelling of the cardiac structure. Flecainide is an Ic antiarrhythmic drug that can be administered in combination with \u03b2-adrenergic blockers to treat ACM due to its ability to target both Nav1.5 and type 2 ryanodine receptors (RyR2). However, a recent study showed that flecainide may also prevent fibro-adipogenic differentiation by inhibiting store-operated Ca2+ entry (SOCE) and thereby suppressing spontaneous Ca2+ oscillations in C-MSCs isolated from human ACM patients (ACM C-hMSCs). Herein, we briefly survey ACM pathogenesis and therapies and then recapitulate the main molecular mechanisms targeted by flecainide to mitigate arrhythmic events, including Nav1.5 and RyR2. Subsequently, we describe the role of spontaneous Ca2+ oscillations in determining MSC fate. Next, we discuss recent work showing that spontaneous Ca2+ oscillations in ACM C-hMSCs are accelerated to stimulate their fibro-adipogenic differentiation. Finally, we describe the evidence that flecainide suppresses spontaneous Ca2+ oscillations and fibro-adipogenic differentiation in ACM C-hMSCs by inhibiting constitutive SOCE.<\/jats:p>","DOI":"10.3390\/jcm12165295","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T10:40:31Z","timestamp":1692009631000},"page":"5295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Store-Operated Ca2+ Entry as a Putative Target of Flecainide for the Treatment of Arrhythmogenic Cardiomyopathy"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-0098","authenticated-orcid":false,"given":"Francesco","family":"Moccia","sequence":"first","affiliation":[{"name":"Department of Biology and Biotechnology \u201cLazzaro Spallanzani\u201d, University of Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u201cLazzaro Spallanzani\u201d, University of Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7728-6815","authenticated-orcid":false,"given":"Teresa","family":"Soda","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-0359","authenticated-orcid":false,"given":"Pawan","family":"Faris","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Scarpellino","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u201cLazzaro Spallanzani\u201d, University of Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-0925","authenticated-orcid":false,"given":"Roberto","family":"Berra-Romani","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, School of Medicine, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla 72410, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41569-019-0200-7","article-title":"Molecular mechanisms of arrhythmogenic cardiomyopathy","volume":"16","author":"Austin","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra1509267","article-title":"Arrhythmogenic Right Ventricular Cardiomyopathy","volume":"376","author":"Corrado","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.15420\/AER.2015.04.02.86","article-title":"Arrhythmogenic Right Ventricular Cardiomyopathy\u2013Antiarrhythmic Therapy","volume":"4","author":"Ermakov","year":"2015","journal-title":"Arrhythmia Electrophysiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1186\/s12967-022-03742-8","article-title":"Ca2+ dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide","volume":"20","author":"Maione","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-physiol-052521-013426","article-title":"Physiological Functions of CRAC Channels","volume":"84","author":"Emrich","year":"2021","journal-title":"Annu. Rev. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Moccia, F., Brunetti, V., Perna, A., Guerra, G., Soda, T., and Berra-Romani, R. (2023). The Molecular Heterogeneity of Store-Operated Ca2+ Entry in Vascular Endothelial Cells: The Different roles of Orai1 and TRPC1\/TRPC4 Channels in the Transition from Ca2+-Selective to Non-Selective Cation Currents. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043259"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1152\/physrev.00020.2014","article-title":"Store-Operated Calcium Channels","volume":"95","author":"Prakriya","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1007\/s00018-017-2545-6","article-title":"ATP-induced Ca2+-signalling mechanisms in the regulation of mesenchymal stem cell migration","volume":"74","author":"Jiang","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.52586\/5065","article-title":"Role of the store-operated Ca2+ channel in ATP-induced Ca2+ signalling in mesenchymal stem cells and regulation of cell functions","volume":"26","author":"Wang","year":"2021","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4252\/wjsc.v13.i4.260","article-title":"Calcium channels and their role in regenerative medicine","volume":"13","author":"Ahamad","year":"2021","journal-title":"World J. Stem Cells"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e003273","DOI":"10.1161\/CIRCGEN.120.003273","article-title":"International Evidence Based Reappraisal of Genes Associated With Arrhythmogenic Right Ventricular Cardiomyopathy Using the Clinical Genome Resource Framework","volume":"14","author":"James","year":"2021","journal-title":"Circ. Genom. Precis. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1172\/JCI27751","article-title":"Suppression of canonical Wnt\/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy","volume":"116","author":"Lombardi","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/eurheartj\/ehv579","article-title":"Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy","volume":"37","author":"Sommariva","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Maione, A.S., Stadiotti, I., Pilato, C.A., Perrucci, G.L., Saverio, V., Catto, V., Vettor, G., Casella, M., Guarino, A., and Polvani, G. (2021). Excess TGF-beta1 Drives Cardiac Mesenchymal Stromal Cells to a Pro-Fibrotic Commitment in Arrhythmogenic Cardiomyopathy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052673"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.pharmtox.45.120403.095802","article-title":"The cardiac fibroblast: Therapeutic target in myocardial remodeling and failure","volume":"45","author":"Brown","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cardiores.2004.08.020","article-title":"Structural and functional characterisation of cardiac fibroblasts","volume":"65","author":"Camelliti","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/CIRCRESAHA.117.309345","article-title":"Arrhythmogenic Cardiomyopathy","volume":"121","author":"Corrado","year":"2017","journal-title":"Circ. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gaine, S.P., and Calkins, H. (2023). Antiarrhythmic Drug Therapy in Arrhythmogenic Right Ventricular Cardiomyopathy. Biomedicines, 11.","DOI":"10.3390\/biomedicines11041213"},{"key":"ref_19","first-page":"278","article-title":"Safety and efficacy of flecainide associated with beta-blockers in arrhythmogenic right ventricular cardiomyopathy","volume":"24","author":"Rolland","year":"2022","journal-title":"EP Eur."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lavalle, C., Trivigno, S., Vetta, G., Magnocavallo, M., Mariani, M.V., Santini, L., Forleo, G.B., Grimaldi, M., Badagliacca, R., and Lanata, L. (2021). Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives. J. Clin. Med., 10.","DOI":"10.3390\/jcm10163696"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Stevens, T.L., Wallace, M.J., Refaey, M.E., Roberts, J.D., Koenig, S.N., and Mohler, P.J. (2020). Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design. J. Cardiovasc. Dev. Dis., 7.","DOI":"10.3390\/jcdd7020021"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1111\/bph.13807","article-title":"Multiple targets for flecainide action: Implications for cardiac arrhythmogenesis","volume":"175","author":"Salvage","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Salvage, S.C., Huang, C.L., Fraser, J.A., and Dulhunty, A.F. (2022). How does flecainide impact RyR2 channel function?. J. Gen. Physiol., 154.","DOI":"10.1085\/jgp.202213089"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4330\/wjc.v7.i2.76","article-title":"Flecainide: Current status and perspectives in arrhythmia management","volume":"7","author":"Andrikopoulos","year":"2015","journal-title":"World J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1161\/CIRCRESAHA.121.318706","article-title":"Is the Debate on the Flecainide Action on the RYR2 in CPVT Closed?","volume":"128","author":"Benitah","year":"2021","journal-title":"Circ. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/europace\/euq382","article-title":"Twenty-five years in the making: Flecainide is safe and effective for the management of atrial fibrillation","volume":"13","author":"Aliot","year":"2011","journal-title":"Europace"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0014-2999(92)90118-N","article-title":"States and sites of actions of flecainide on guinea-pig cardiac sodium channels","volume":"214","author":"Nitta","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3389\/fphar.2020.00413","article-title":"Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents","volume":"11","author":"Horvath","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1085\/jgp.200308857","article-title":"State-dependent block of wild-type and inactivation-deficient Na+ channels by flecainide","volume":"122","author":"Wang","year":"2003","journal-title":"J. Gen. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1124\/jpet.112.198887","article-title":"A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias","volume":"344","author":"Belardinelli","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.yjmcc.2015.06.021","article-title":"Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide","volume":"86","author":"Melgari","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1161\/CIRCRESAHA.120.316819","article-title":"RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT","volume":"128","author":"Kryshtal","year":"2021","journal-title":"Circ. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1111\/bph.15718","article-title":"Moving in the right direction: Elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor","volume":"179","author":"Bannister","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/CIRCEP.110.959916","article-title":"Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia","volume":"4","author":"Hwang","year":"2011","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJM199103213241201","article-title":"Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial","volume":"324","author":"Echt","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/jce.14335","article-title":"Class 1C antiarrhythmic drugs in atrial fibrillation and coronary artery disease","volume":"31","author":"Pantlin","year":"2020","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s40256-021-00483-9","article-title":"Use of Flecainide in Stable Coronary Artery Disease: An Analysis of Its Safety in Both Nonobstructive and Obstructive Coronary Artery Disease","volume":"21","author":"Ashraf","year":"2021","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"I47","DOI":"10.1093\/eurheartjsupp\/suac073","article-title":"The many NOs to the use of Class IC antiarrhythmics: Weren\u2019t the guidelines too strict?","volume":"24","author":"Turturiello","year":"2022","journal-title":"Eur. Heart J. Suppl."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.hrthm.2016.12.010","article-title":"Use of flecainide in combination antiarrhythmic therapy in patients with arrhythmogenic right ventricular cardiomyopathy","volume":"14","author":"Ermakov","year":"2017","journal-title":"Heart Rhythm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.1016\/j.hrthm.2019.09.019","article-title":"2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary","volume":"16","author":"Towbin","year":"2019","journal-title":"Heart Rhythm."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Moccia, F., Lodola, F., Stadiotti, I., Pilato, C.A., Bellin, M., Carugo, S., Pompilio, G., Sommariva, E., and Maione, A.S. (2019). Calcium as a Key Player in Arrhythmogenic Cardiomyopathy: Adhesion Disorder or Intracellular Alteration?. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20163986"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41467-017-00127-0","article-title":"Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm","volume":"8","author":"Cerrone","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/CIRCRESAHA.117.310230","article-title":"Calcium and Excitation-Contraction Coupling in the Heart","volume":"121","author":"Eisner","year":"2017","journal-title":"Circ. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1161\/CIRCULATIONAHA.119.039710","article-title":"Disruption of Ca2+i Homeostasis and Connexin 43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in Plakophilin-2-Deficient Mice","volume":"140","author":"Kim","year":"2019","journal-title":"Circulation"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1161\/CIRCULATIONAHA.121.057757","article-title":"Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2-Deficient Hearts","volume":"145","author":"Bagwan","year":"2022","journal-title":"Circulation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"eabf0891","DOI":"10.1126\/scitranslmed.abf0891","article-title":"Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy","volume":"13","author":"Chelko","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1161\/CIRCRESAHA.110.226845","article-title":"Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis","volume":"108","author":"Priori","year":"2011","journal-title":"Circ. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrcardio.2012.93","article-title":"Inherited calcium channelopathies in the pathophysiology of arrhythmias","volume":"9","author":"Venetucci","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e319","DOI":"10.1002\/ctm2.319","article-title":"Deciphering DSC2 arrhythmogenic cardiomyopathy electrical instability: From ion channels to ECG and tailored drug therapy","volume":"11","author":"Moreau","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ceca.2016.02.001","article-title":"Physiology of Ca2+ signalling in stem cells of different origins and differentiation stages","volume":"59","author":"Forostyak","year":"2016","journal-title":"Cell Calcium"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Torre, E.C., Bicer, M., Cottrell, G.S., Widera, D., and Tamagnini, F. (2021). Time-Dependent Reduction of Calcium Oscillations in Adipose-Derived Stem Cells Differentiating towards Adipogenic and Osteogenic Lineage. Biomolecules, 11.","DOI":"10.3390\/biom11101400"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2174\/1389450116666141219121723","article-title":"Intracellular Ca2+ Signals to Reconstruct A Broken Heart: Still A Theoretical Approach?","volume":"16","author":"Moccia","year":"2015","journal-title":"Curr. Drug Targets"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"874043","DOI":"10.3389\/fcell.2022.874043","article-title":"Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells","volume":"10","author":"Faris","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0143416002001240","article-title":"Characterization of Ca2+ signaling pathways in human mesenchymal stem cells","volume":"32","author":"Kawano","year":"2002","journal-title":"Cell Calcium"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0143-4160(03)00069-1","article-title":"Ca2+ oscillations regulated by Na+-Ca2+ exchanger and plasma membrane Ca2+ pump induce fluctuations of membrane currents and potentials in human mesenchymal stem cells","volume":"34","author":"Kawano","year":"2003","journal-title":"Cell Calcium"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ceca.2005.11.008","article-title":"ATP autocrine\/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells","volume":"39","author":"Kawano","year":"2006","journal-title":"Cell Calcium"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSS2007c01","article-title":"Inositol trisphosphate and calcium oscillations","volume":"74","author":"Berridge","year":"2007","journal-title":"Biochem. Soc. Symp."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.bbamcr.2008.10.005","article-title":"Inositol trisphosphate and calcium signalling mechanisms","volume":"1793","author":"Berridge","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/emboj\/18.5.1303","article-title":"Encoding of Ca2+ signals by differential expression of IP3 receptor subtypes","volume":"18","author":"Miyakawa","year":"1999","journal-title":"EMBO J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"L459","DOI":"10.1152\/ajplung.00092.2005","article-title":"Mechanism of ACh-induced asynchronous calcium waves and tonic contraction in porcine tracheal muscle bundle","volume":"290","author":"Dai","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.cub.2009.03.063","article-title":"Decoding of cytoplasmic Ca2+ oscillations through the spatial signature drives gene expression","volume":"19","author":"Ng","year":"2009","journal-title":"Curr. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1002\/jcp.26953","article-title":"Glutamate triggers intracellular Ca2+ oscillations and nitric oxide release by inducing NAADP- and InsP3 -dependent Ca2+ release in mouse brain endothelial cells","volume":"234","author":"Zuccolo","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8074","DOI":"10.1111\/jcmm.16739","article-title":"The human amniotic fluid stem cell secretome triggers intracellular Ca2+ oscillations, NF-kappaB nuclear translocation and tube formation in human endothelial colony-forming cells","volume":"25","author":"Balducci","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/jcp.29071","article-title":"Histamine induces intracellular Ca2+ oscillations and nitric oxide release in endothelial cells from brain microvascular circulation","volume":"235","author":"Faris","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5802","DOI":"10.2174\/092986712804143240","article-title":"Store-dependent Ca2+ entry in endothelial progenitor cells as a perspective tool to enhance cell-based therapy and adverse tumour vascularization","volume":"19","author":"Moccia","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/s41467-017-01644-8","article-title":"Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions","volume":"8","author":"Thillaiappan","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceb.2018.10.001","article-title":"IP3 receptors and store-operated Ca2+ entry: A license to fill","volume":"57","author":"Taylor","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"108760","DOI":"10.1016\/j.celrep.2021.108760","article-title":"Omnitemporal choreographies of all five STIM\/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling","volume":"34","author":"Emrich","year":"2021","journal-title":"Cell Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"a035055","DOI":"10.1101\/cshperspect.a035055","article-title":"Store-Operated Calcium Channels: From Function to Structure and Back Again","volume":"12","author":"Lewis","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.cell.2007.11.039","article-title":"STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels","volume":"131","author":"Brandman","year":"2007","journal-title":"Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e2114928118","DOI":"10.1073\/pnas.2114928118","article-title":"Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE","volume":"119","author":"Ahmad","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.celrep.2018.03.065","article-title":"STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions","volume":"23","author":"Subedi","year":"2018","journal-title":"Cell Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00249-017-1216-8","article-title":"Constitutive calcium entry and cancer: Updated views and insights","volume":"46","author":"Mignen","year":"2017","journal-title":"Eur. Biophys. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fncel.2015.00153","article-title":"Stim and Orai proteins in neuronal Ca2+ signaling and excitability","volume":"9","author":"Moccia","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1002\/jcp.27234","article-title":"Muscarinic M5 receptors trigger acetylcholine-induced Ca2+ signals and nitric oxide release in human brain microvascular endothelial cells","volume":"234","author":"Zuccolo","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1038\/s41467-020-16232-6","article-title":"The native ORAI channel trio underlies the diversity of Ca2+ signaling events","volume":"11","author":"Yoast","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"14714","DOI":"10.1038\/ncomms14714","article-title":"ORAI2 modulates store-operated calcium entry and T cell-mediated immunity","volume":"8","author":"Vaeth","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"eaav4663","DOI":"10.1126\/scisignal.aav4663","article-title":"Differential regulation of Ca2+ influx by ORAI channels mediates enamel mineralization","volume":"12","author":"Eckstein","year":"2019","journal-title":"Sci. Signal."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.bbrc.2016.04.068","article-title":"Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells","volume":"473","author":"Lee","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41536-021-00180-w","article-title":"Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation\/viability and tissue regeneration","volume":"6","author":"Ahamad","year":"2021","journal-title":"NPJ Regen. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"102560","DOI":"10.1016\/j.scr.2021.102560","article-title":"Increasing cytosolic Ca2+ levels restore cell proliferation and stem cell potency in aged MSCs","volume":"56","author":"Ahamad","year":"2021","journal-title":"Stem Cell Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/stem.2370","article-title":"Purinergic and Store-Operated Ca2+ Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP-Induced Stimulation of Cell Migration","volume":"34","author":"Peng","year":"2016","journal-title":"Stem Cells"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jcp.21598","article-title":"Substrate rigidity regulates Ca2+ oscillation via RhoA pathway in stem cells","volume":"218","author":"Kim","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1111\/j.1582-4934.2011.01263.x","article-title":"Cyclic ADP ribose is a novel regulator of intracellular Ca2+ oscillations in human bone marrow mesenchymal stem cells","volume":"15","author":"Tao","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1002\/jcp.22495","article-title":"NOS inhibition synchronizes calcium oscillations in human adipose tissue-derived mesenchymal stem cells by increasing gap-junctional coupling","volume":"226","author":"Sauer","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e2101318","DOI":"10.1002\/adhm.202101318","article-title":"Stem\/Proliferative and Differentiated Cells within Primary Murine Colonic Epithelium Display Distinct Intracellular Free Ca2+ Signal Codes","volume":"10","author":"Mestril","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Okada, H., Okabe, K., and Tanaka, S. (2020). Finely-Tuned Calcium Oscillations in Osteoclast Differentiation and Bone Resorption. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010180"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e17113","DOI":"10.7554\/eLife.17113","article-title":"Calcium handling precedes cardiac differentiation to initiate the first heartbeat","volume":"5","author":"Tyser","year":"2016","journal-title":"eLife"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1002\/jcp.26120","article-title":"Mesenchymal stem cell differentiation: Control by calcium-activated potassium channels","volume":"233","author":"Pchelintseva","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"743476","DOI":"10.1155\/2010\/743476","article-title":"Physicochemical control of adult stem cell differentiation: Shedding light on potential molecular mechanisms","volume":"2010","author":"Titushkin","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1096\/fj.06-7153com","article-title":"Physical manipulation of calcium oscillations facilitates osteodifferentiation of human mesenchymal stem cells","volume":"21","author":"Sun","year":"2007","journal-title":"FASEB J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9657","DOI":"10.1074\/jbc.M110.185124","article-title":"EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling","volume":"286","author":"Yu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.yexcr.2009.08.006","article-title":"Limited Ca2+ and PKA-pathway dependent neurogenic differentiation of human adult mesenchymal stem cells as compared to fetal neuronal stem cells","volume":"316","author":"Lepski","year":"2010","journal-title":"Exp. Cell Res."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Mozolewski, P., Jeziorek, M., Schuster, C.M., Bading, H., Frost, B., and Dobrowolski, R. (2021). The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health. J. Cell Sci., 134.","DOI":"10.1242\/jcs.254904"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13287-017-0536-z","article-title":"Electrical control of calcium oscillations in mesenchymal stem cells using microsecond pulsed electric fields","volume":"8","author":"Hanna","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.biomaterials.2015.10.078","article-title":"Electrically driven intracellular and extracellular nanomanipulators evoke neurogenic\/cardiomyogenic differentiation in human mesenchymal stem cells","volume":"77","author":"Thrivikraman","year":"2016","journal-title":"Biomaterials"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.reth.2023.04.001","article-title":"Carbachol, along with calcium, indicates new strategy in neural differentiation of human adipose tissue-derived mesenchymal stem cells in vitro","volume":"23","author":"Masoumi","year":"2023","journal-title":"Regen. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41467-017-02638-2","article-title":"Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria","volume":"9","author":"Samanta","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000329618","article-title":"The mechanism of injury-induced intracellular calcium concentration oscillations in the endothelium of excised rat aorta","volume":"49","author":"Raqeeb","year":"2012","journal-title":"J. Vasc. Res."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Scorza, S.I., Milano, S., Saponara, I., Certini, M., De Zio, R., Mola, M.G., Procino, G., Carmosino, M., Moccia, F., and Svelto, M. (2023). TRPML1-Induced Lysosomal Ca2+ Signals Activate AQP2 Translocation and Water Flux in Renal Collecting Duct Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021647"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"31098","DOI":"10.18632\/oncotarget.25785","article-title":"Stim and Orai mediate constitutive Ca2+ entry and control endoplasmic reticulum Ca2+ refilling in primary cultures of colorectal carcinoma cells","volume":"9","author":"Zuccolo","year":"2018","journal-title":"Oncotarget"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Faris, P., Rumolo, A., Tapella, L., Tanzi, M., Metallo, A., Conca, F., Negri, S., Lefkimmiatis, K., Pedrazzoli, P., and Lim, D. (2022). Store-Operated Ca2+ Entry Is Up-Regulated in Tumour-Infiltrating Lymphocytes from Metastatic Colorectal Cancer Patients. Cancers, 14.","DOI":"10.3390\/cancers14143312"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"629119","DOI":"10.3389\/fphys.2021.629119","article-title":"Targeting Endolysosomal Two-Pore Channels to Treat Cardiovascular Disorders in the Novel COronaVIrus Disease 2019","volume":"12","author":"Moccia","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/bs.ircmb.2021.03.001","article-title":"Endolysosomal Ca2+ signaling in cardiovascular health and disease","volume":"363","author":"Negri","year":"2021","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1242\/jcs.118836","article-title":"Direct mobilisation of lysosomal Ca2+ triggers complex Ca2+ signals","volume":"126","author":"Kilpatrick","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/jcp.29896","article-title":"Nicotinic acid adenine dinucleotide phosphate activates two-pore channel TPC1 to mediate lysosomal Ca2+ release in endothelial colony-forming cells","volume":"236","author":"Moccia","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Gul, R., Park, D.R., Shawl, A.I., Im, S.Y., Nam, T.S., Lee, S.H., Ko, J.K., Jang, K.Y., Kim, D., and Kim, U.H. (2016). Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by beta-Adrenergic Stimulation. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0149125"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"30087","DOI":"10.1074\/jbc.M115.684076","article-title":"Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic beta-Adrenoceptor Signaling in the Heart","volume":"290","author":"Capel","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/cvr\/cvv226","article-title":"Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore","volume":"108","author":"Davidson","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"40797","DOI":"10.1038\/srep40797","article-title":"TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry","volume":"7","author":"Sbano","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-pharmtox-051421-111814","article-title":"CaMKII as a Therapeutic Target in Cardiovascular Disease","volume":"63","author":"Nkashama","year":"2023","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.bbagen.2013.11.015","article-title":"Frequency decoding of calcium oscillations","volume":"1840","author":"Smedler","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA)-Gen. Subj."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.tibs.2010.07.013","article-title":"Decoding cytosolic Ca2+ oscillations","volume":"36","author":"Parekh","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Rostas, J.A.P., and Skelding, K.A. (2023). Calcium\/Calmodulin-Stimulated Protein Kinase II (CaMKII): Different Functional Outcomes from Activation, Depending on the Cellular Microenvironment. Cells, 12.","DOI":"10.3390\/cells12030401"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1126\/science.279.5348.227","article-title":"Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations","volume":"279","author":"Schulman","year":"1998","journal-title":"Science"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0143-4160(03)00152-0","article-title":"Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations: A simple model","volume":"34","author":"Dupont","year":"2003","journal-title":"Cell Calcium"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ydbio.2004.04.008","article-title":"Fertilization stimulates long-lasting oscillations of CaMKII activity in mouse eggs","volume":"272","author":"Markoulaki","year":"2004","journal-title":"Dev. Biol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000495171","article-title":"Calcium Supplementation Enhanced Adipogenesis and Improved Glucose Homeostasis Through Activation of Camkii and PI3K\/Akt Signaling Pathway in Porcine Bone Marrow Mesenchymal Stem Cells (pBMSCs) and Mice Fed High Fat Diet (HFD)","volume":"51","author":"Zhang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41577-018-0110-7","article-title":"Calcium signalling in T cells","volume":"19","author":"Trebak","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e75055","DOI":"10.7554\/eLife.75055","article-title":"Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer\u2019s disease transgenic mice","volume":"11","author":"Abjorsbraten","year":"2022","journal-title":"eLife"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"102347","DOI":"10.1016\/j.coph.2022.102347","article-title":"Store-operated calcium entry: From physiology to tubular aggregate myopathy","volume":"68","author":"Protasi","year":"2023","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1161\/CIRCRESAHA.122.321041","article-title":"Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension","volume":"131","author":"Masson","year":"2022","journal-title":"Circ. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.2174\/0929867323666160607111220","article-title":"Targeting Stim and Orai Proteins as an Alternative Approach in Anticancer Therapy","volume":"23","author":"Moccia","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Sabourin, J., Beauvais, A., Luo, R., Montani, D., Benitah, J.P., Masson, B., and Antigny, F. (2022). The SOCE Machinery: An Unbalanced Knowledge between Left and Right Ventricular Pathophysiology. Cells, 11.","DOI":"10.3390\/cells11203282"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"13394","DOI":"10.1074\/jbc.M115.693911","article-title":"Transient Receptor Potential Canonical (TRPC)\/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES","volume":"291","author":"Sabourin","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"102605","DOI":"10.1016\/j.ceca.2022.102605","article-title":"STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39","volume":"105","author":"Riva","year":"2022","journal-title":"Cell Calcium"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"586109","DOI":"10.3389\/fcell.2020.586109","article-title":"Targeting Orai1-Mediated Store-Operated Ca2+ Entry in Heart Failure","volume":"8","author":"Luo","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-3-319-57732-6_7","article-title":"The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels","volume":"993","author":"Ma","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1021\/acsptsci.9b00081","article-title":"A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions","volume":"3","author":"Azimi","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2174\/18715206113139990315","article-title":"Orai1 and Transient Receptor Potential Channels as novel molecular targets to impair tumor neovascularisation in renal cell carcinoma and other malignancies","volume":"14","author":"Moccia","year":"2014","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2174\/157436212800376672","article-title":"Hematopoietic progenitor and stem cells circulate by surfing on intracellular Ca2+ waves: A novel target for cell-based therapy and anti-cancer treatment?","volume":"7","author":"Moccia","year":"2012","journal-title":"Curr. Signal Transduct. Ther."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"37919","DOI":"10.1074\/jbc.M111.251777","article-title":"Ca2+ influx through reverse mode Na+\/ Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1\/2 activation and angiogenic functions of human endothelial cells","volume":"286","author":"Andrikopoulos","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"16846","DOI":"10.1074\/jbc.M110.187559","article-title":"Angiogenic functions of voltage-gated Na+ Channels in human endothelial cells: Modulation of vascular endothelial growth factor (VEGF) signaling","volume":"286","author":"Andrikopoulos","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ceca.2018.07.005","article-title":"CRAC channels as targets for drug discovery and development","volume":"74","author":"Stauderman","year":"2018","journal-title":"Cell Calcium"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"817","DOI":"10.4155\/fmc-2016-0024","article-title":"Store-operated CRAC channel inhibitors: Opportunities and challenges","volume":"8","author":"Tian","year":"2016","journal-title":"Future Med. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/j.1476-5381.2012.02126.x","article-title":"Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca2+ entry pathways","volume":"167","author":"Schleifer","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"102281","DOI":"10.1016\/j.ceca.2020.102281","article-title":"Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels","volume":"91","author":"Zhang","year":"2020","journal-title":"Cell Calcium"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fphar.2016.00486","article-title":"Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain","volume":"7","author":"Chauvet","year":"2016","journal-title":"Front. Pharmacol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ceca.2017.06.003","article-title":"Acetylcholine induces intracellular Ca2+ oscillations and nitric oxide release in mouse brain endothelial cells","volume":"66","author":"Zuccolo","year":"2017","journal-title":"Cell Calcium"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1124\/mol.105.021154","article-title":"A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity","volume":"69","author":"Takezawa","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"12427","DOI":"10.1074\/jbc.M309297200","article-title":"Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2","volume":"279","author":"Zitt","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"402","DOI":"10.4161\/chan.25292","article-title":"Molecular pharmacology of store-operated CRAC channels","volume":"7","author":"Jairaman","year":"2013","journal-title":"Channels"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"19265","DOI":"10.1074\/jbc.M801535200","article-title":"Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry","volume":"283","author":"DeHaven","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/scd.2015.0240","article-title":"Constitutive Store-Operated Ca2+ Entry Leads to Enhanced Nitric Oxide Production and Proliferation in Infantile Hemangioma-Derived Endothelial Colony-Forming Cells","volume":"25","author":"Zuccolo","year":"2016","journal-title":"Stem Cells Dev."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1055\/s-0038-1676855","article-title":"Kinetic and Angiogenic Activity of Circulating Endothelial Colony Forming Cells in Patients with Infantile Haemangioma Receiving Propranolol","volume":"119","author":"Campanelli","year":"2019","journal-title":"Thromb. Haemost."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"12881","DOI":"10.1038\/s41598-017-13343-x","article-title":"Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway","volume":"7","author":"Rahman","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1046\/j.1471-4159.1997.68052119.x","article-title":"Differential inactivation of postsynaptic density-associated and soluble Ca2+\/calmodulin-dependent protein kinase II by protein phosphatases 1 and 2A","volume":"68","author":"Strack","year":"1997","journal-title":"J. Neurochem."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Shioda, N., and Fukunaga, K. (2017). Physiological and Pathological Roles of CaMKII-PP1 Signaling in the Brain. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010020"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"C1426","DOI":"10.1152\/ajpcell.00262.2005","article-title":"Modulation of intracellular Ca2+ release and capacitative Ca2+ entry by CaMKII inhibitors in bovine vascular endothelial cells","volume":"289","author":"Aromolaran","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1159\/000488835","article-title":"CaMKII Potentiates Store-Operated Ca2+ Entry Through Enhancing STIM1 Aggregation and Interaction with Orai1","volume":"46","author":"Li","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.carpath.2016.11.004","article-title":"CaMKIIdelta meditates phenylephrine induced cardiomyocyte hypertrophy through store-operated Ca2+ entry","volume":"27","author":"Ji","year":"2017","journal-title":"Cardiovasc. Pathol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/16\/5295\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:33:28Z","timestamp":1760128408000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/16\/5295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,14]]},"references-count":151,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["jcm12165295"],"URL":"https:\/\/doi.org\/10.3390\/jcm12165295","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,14]]}}}