{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:12:23Z","timestamp":1793650343497,"version":"4.5.1"},"reference-count":32,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study aimed to analyse the effectiveness of four different designs of the Mandibular Advancement Device (MAD) and the morphological changes on upper airway characteristics of Obstructive Sleep Apnea (OSA) patients inducted by each of them, detected by Cone Beam Computer Tomography (CBCT) 3D imaging. Twenty-two patients were recruited after an OSA diagnosis with PSG. Four different customised and titratable MADs were used and an initial CBCT scan was obtained for each patient. Six months after the end of the MAD titration phase, all the subjects performed a second PSG with the MAD in situ; the second PSG showed an Apnoea\u2013Hypopnoea Index (AHI) of &lt;5 or a decrease of 50% in AHI when compared with the initial AHI. Moreover, a second CBCT scan with the MAD in situ was performed. DICOM files were imported into the airway analysis software programme and the pharyngeal area around the oropharynx was highlighted. The area and volume of the oropharynx with and without the device was evaluated. A considerable improvement of the airway was observed (+33.76%), and a significant difference in the enlargement ratio between the posterior soft palate (+32.41%) and the posterior tongue (+36.96%) region was also found. The greatest increase in airway volume was achieved in patients treated with the MAD Forward and TAP (+42.77% and +41.63%, respectively). MAD therapy is effective to treat moderate to severe OSA with an increased upper airway volume. The design of the MAD can influence the effectiveness of the treatment.<\/jats:p>","DOI":"10.3390\/jcm12165315","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T10:09:33Z","timestamp":1692180573000},"page":"5315","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Upper Airway Characteristics and Morphological Changes by Different MADs in OSA Adult Subjects Assessed by CBCT 3D Imaging"],"prefix":"10.3390","volume":"12","author":[{"given":"Nicol\u00f2","family":"Venza","sequence":"first","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-3371","authenticated-orcid":false,"given":"Arianna","family":"Malara","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Liguori","sequence":"additional","affiliation":[{"name":"Sleep Medicine Centre, Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2663-8291","authenticated-orcid":false,"given":"Paola","family":"Cozza","sequence":"additional","affiliation":[{"name":"UniCamillus\u2014Saint Camillus International University of Health Sciences, 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Lagan\u00e0","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"},{"name":"UniCamillus\u2014Saint Camillus International University of Health Sciences, 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.chest.2017.01.020","article-title":"Effects of CPAP and Mandibular Advancement Devices on Health-Related Quality of Life in OSA: A Systematic Review and meta-analysis","volume":"151","author":"Kuhn","year":"2017","journal-title":"Chest"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"American Academy of Sleep Medicine Task Force (1999). Sleep-related breathing disorders in adults: Recommendations for syndrome definition and measurement techniques in clinical research. Sleep, 22, 667\u2013689.","DOI":"10.1093\/sleep\/22.5.667"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.5005\/jp-journals-10001-1379","article-title":"American Academy of Sleep Medicine Guidelines, 2018","volume":"10","author":"Singh","year":"2019","journal-title":"Int. J. Head Neck Surg."},{"key":"ref_4","unstructured":"Iber, C., Ancoli-Israel, S., and Chesson, A. (2007). The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, American Academy of Sleep Medicine. [1st ed.]."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Venza, N., Alloisio, G., Gioia, M., Liguori, C., Nappi, A., Danesi, C., and Lagan\u00e0, G. (2022). Saliva Analysis of pH and Antioxidant Capacity in Adult Obstructive Sleep Apnea Patients. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192013219"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lagan\u00e0, G., Venza, N., Malara, A., Liguori, C., Cozza, P., and Pisano, C. (2021). Obstructive Sleep Apnea, Palatal Morphology, and Aortic Dilatation in Marfan Syndrome Growing Subjects: A Retrospective Study. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18063045"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lagan\u00e0, G., Osmanagiq, V., Malara, A., Venza, N., and Cozza, P. (2021). Sleep Bruxism and SDB in Albanian Growing Subjects: A Cross-Sectional Study. Dent. J., 9.","DOI":"10.3390\/dj9030025"},{"key":"ref_8","first-page":"925","article-title":"Obstructive sleep apnea syndrome (OSAS)","volume":"17","year":"2012","journal-title":"Rev. Lit. Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41392-023-01496-3","article-title":"Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome","volume":"8","author":"Lv","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.ijom.2010.09.007","article-title":"Biomechanics of the upper airway: Changing concepts in the pathogenesis of obstructive sleep apnea","volume":"39","author":"Susarla","year":"2010","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"479","DOI":"10.5664\/jcsm.6506","article-title":"Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline","volume":"13","author":"Kapur","year":"2017","journal-title":"J. Clin. Sleep Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1253\/circj.CJ-09-0364","article-title":"Obstructive sleep apnea and cardiovascular disease","volume":"73","author":"Kato","year":"2009","journal-title":"Circ. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1601-6343.2010.01482.x","article-title":"An analysis of different approaches to the assessment of upper airway morphology: A CBCT study","volume":"13","author":"Lenza","year":"2010","journal-title":"Orthod. Craniofac."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5664\/jcsm.3460","article-title":"Oral appliance treatment for obstructive sleep apnea: An update","volume":"10","author":"Sutherland","year":"2014","journal-title":"J. Clin. Sleep Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00784-014-1234-1","article-title":"Effect of oral appliance on endothelial function in sleep apnea","volume":"19","author":"Lin","year":"2014","journal-title":"Clin. Oral Investig."},{"key":"ref_16","first-page":"9","article-title":"Cardiovascular beneMits of oral appliance therapy in obstructive sleep apnea: A systematic review","volume":"2","author":"Dieltjens","year":"2015","journal-title":"J. Dent. Sleep Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5664\/jcsm.5480","article-title":"Improvement of cognitive and psychomotor performance in patients with mild to moderate obstructive sleep apnea treated with mandibular advancement device: A prospective 1-year study","volume":"12","author":"Galic","year":"2016","journal-title":"J. Clin. Sleep Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s11325-012-0799-7","article-title":"CBCT assess- ment of upper airway changes and treatment outcomes of obstructive sleep apnoea: A systematic review","volume":"17","author":"Alsufyani","year":"2013","journal-title":"Sleep Breath"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1080\/08869634.2020.1765602","article-title":"Use of cone beam computed tomography imaging for airway measurement to predict obstructive sleep apnea","volume":"40","author":"Chaudhry","year":"2020","journal-title":"Cranio"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ajodo.2018.05.022","article-title":"Changes in sleep and airway variables in patients with obstructive sleep apnea after mandibular advancement splint treatment","volume":"155","author":"Mostafiz","year":"2019","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1001\/jama.290.14.1906","article-title":"Obstructive sleep apnea: Implications for cardiac and vascular disease","volume":"290","author":"Shamsuzzaman","year":"2003","journal-title":"JAMA"},{"key":"ref_22","first-page":"661","article-title":"A study to evaluate the effect of different mandibular horizontal and vertical jaw positions on sleep parameters in patients with obstructive sleep apnea","volume":"47","author":"Gupta","year":"2016","journal-title":"Quintessence Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1164\/rccm.200204-342OC","article-title":"Effect of vertical dimension on efficacy of oral appliance therapy in obstructive sleep apnea","volume":"166","author":"Pitsis","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ye Min Soe, K.T., Ishiyama, H., Nishiyama, A., Shimada, M., and Maeda, S. (2022). Effect of Different Maxillary Oral Appliance Designs on Respiratory Variables during Sleep. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19116714"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Abazi, Y., Cenko, F., Cardella, M., Tafa, G., and Lagan\u00e0, G. (2020). Sleep Disordered Breathing: An Epidemiological Study among Albanian Children and Adolescents. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17228586"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"398","DOI":"10.5935\/1984-0063.20210032","article-title":"Mandibular advancement devices in obstructive sleep apnea: An updated review","volume":"15","author":"Manetta","year":"2022","journal-title":"Sleep Sci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Abd-Ellah, M.E., Mohamed, F.S., Khamis, M.M., and Abdel Wahab, N.H. (2022). Modified biblock versus monoblock mandibular advancement appliances for treatment of obstructive sleep apnea: A randomized controlled trial. J. Prosthet. Dent.","DOI":"10.1016\/j.prosdent.2022.02.019"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.jcms.2014.05.007","article-title":"Different therapeutic mechanisms of rigid and semi-rigid mandibular repositioning devices in obstructive sleep apnea syndrome","volume":"42","author":"Suga","year":"2014","journal-title":"J. Cranio.-Maxillo.-Fac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1164\/ajrccm.162.1.9908112","article-title":"A randomized, controlled crossover trial of two oral appliances for sleep apnea treatment","volume":"162","author":"Bloch","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"962","DOI":"10.2319\/040314-245.1","article-title":"An evaluation of two different mandibular advancement devices on craniofacial characteristics and upper airway dimensions of Chinese adult obstructive sleep apnea patients","volume":"85","author":"Geoghegan","year":"2015","journal-title":"Angle Orthod."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"397","DOI":"10.5665\/sleep.2458","article-title":"Tongue and lateral upper airway movement with mandibular advancement","volume":"36","author":"Brown","year":"2013","journal-title":"Sleep"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1259\/dmfr\/45926904","article-title":"The reliability of computed tomography (CT) values and dimensional measurements of the oropharyngeal region using cone beam CT: Comparison with multidetector CT","volume":"37","author":"Yamashina","year":"2008","journal-title":"Dento. Maxillo. Fac. Radiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/16\/5315\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:34:28Z","timestamp":1760128468000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/16\/5315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,15]]},"references-count":32,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["jcm12165315"],"URL":"https:\/\/doi.org\/10.3390\/jcm12165315","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,15]]}}}