{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:47:40Z","timestamp":1769021260819,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Alzheimer\u2019s disease causes great changes, with the prefrontal cortex being the most frequently damaged zone; these changes affect physical and cognitive behavior and compromise autonomy. Objective: The objective of this study was to evaluate the effects of physical\u2013cognitive tasks on memory, attention, balance, gait, and risk of falling in Alzheimer\u2019s by using feedback-based technology. Methods: Forty patients with Alzheimer\u2019s were recruited from an Alzheimer\u2019s Association; of these, 15 met the inclusion criteria and were included in the pilot RCT (eight in the control group; seven in the experimental group). Assessment tools: The Cognitive Mini-Examination Scale, Oddball Test and Attention Network, Berg Scale, Tinetti, Timed Up and Go, and Geriatric Deterioration Scale. The experimental group was treated with physical\u2013cognitive tasks by using combined feedback-based technology (visual, acoustic, simultaneous, immediate, and terminal feedback, as well as knowledge of the results and performance) under the supervision of physiotherapists twice per week for 16 thirty-minute sessions. The control group underwent their usual care (pharmacological treatment, mobility exercises, and cognitive stimulation sessions). Result: In the experimental group, the contrast tests showed differences for the re-test (except in attention), with the significative Timed Up and Go test being significant (p = 0.020). The interaction between groups showed significant differences for the experimental group according to the MEC (p = 0.029; d = 0.14) and Tinetti (p = 0.029; d = 0.68). Discussion\/Conclusion: Memory, balance, gait, and risk of falling improved in the Alzheimer\u2019s patients through the use of physical\u2013cognitive tasks involving combined feedback-based technology. The effects on attention were inconclusive. The outcomes should be treated with caution due to the sample. This can promote intergenerational bonds, use at home, and adherence to treatment.<\/jats:p>","DOI":"10.3390\/jcm12175484","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:23:40Z","timestamp":1692872620000},"page":"5484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of Physical\u2013Cognitive Tasks Including Feedback-Based Technology for Alzheimer\u2019s Disorder in a Randomized Experimental Pilot Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2058-8799","authenticated-orcid":false,"given":"Maria-Luisa","family":"Benitez-Lugo","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, Faculty of Nursery, Physiotherapy and Podiatry, University of Seville, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Vazquez-Marrufo","sequence":"additional","affiliation":[{"name":"Department of Experimental Phycology, Faculty of Phycology, University of Seville, 41018 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9611-3939","authenticated-orcid":false,"given":"Elena","family":"Pinero-Pinto","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Nursery, Physiotherapy and Podiatry, University of Seville, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4592-0882","authenticated-orcid":false,"given":"Gema","family":"Chamorro-Moriana","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Nursery, Physiotherapy and Podiatry, University of Seville, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3896-357X","authenticated-orcid":false,"given":"Veronica","family":"Perez-Cabezas","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Nursery and Physiotherapy, University of Cadiz, 11009 Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-5811","authenticated-orcid":false,"given":"Carmen","family":"Suarez-Serrano","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Nursery, Physiotherapy and Podiatry, University of Seville, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/geront\/gnw266","article-title":"Defining and Estimating Healthy Aging in Spain: A Cross-Sectional Study","volume":"58","author":"McLaughlin","year":"2018","journal-title":"Gerontologist"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0140-6736(09)61460-4","article-title":"Ageing Populations: The Challenges Ahead","volume":"374","author":"Christensen","year":"2009","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.brainres.2017.10.025","article-title":"Evaluating Functional Connectivity of Executive Control Network and Frontoparietal Network in Alzheimer\u2019s Disease","volume":"1678","author":"Zhao","year":"2018","journal-title":"Brain Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/mds.21720","article-title":"The Role of Executive Function and Attention in Gait","volume":"23","author":"Hausdorff","year":"2008","journal-title":"Mov. 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