{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:27:21Z","timestamp":1760149641228,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We evaluated the feasibility of hybrid percutaneous coronary intervention (PCI) and minimally invasive mitral valve surgery (MIMVS) in patients with concomitant coronary and mitral disease. Of 534 patients who underwent MIMVS at our institution between 2012 and 2018, those with combined mitral and single vessel coronary pathologies who underwent MIMVS and PCI were included. Patients were excluded if they had endocarditis or required emergency procedures. Preprocedural, procedural, and postprocedural data were retrospectively analyzed. In total, 10 patients (median age, 75 years; 7 males) with a median ejection fraction (EF) of 60% were included. Nine patients underwent PCI before and one after MIMVS. The success rate was 100% in both procedures. There were no postoperative myocardial infarctions or strokes. Two patients developed delirium and one required re-thoracotomy for bleeding. The median stay in intensive care and the hospital was 3 and 8 days, respectively. The 30-day survival rate was 100%. A hybrid PCI and MIMVS approach is feasible in patients with mitral valve and single vessel coronary disease. In combined pathologies, the revascularization strategy should be evaluated independent from the mitral valve pathology in the presence of MIMVS expertise. Extension of this recommendation to multivessel disease should be evaluated in future studies.<\/jats:p>","DOI":"10.3390\/jcm12175553","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:46:47Z","timestamp":1693201607000},"page":"5553","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined Minimally Invasive Mitral Valve Surgery and Percutaneous Coronary Intervention: A Hybrid Concept for Patients with Mitral Valve and Coronary Pathologies"],"prefix":"10.3390","volume":"12","author":[{"given":"Mart\u00edn","family":"Moscoso-Ludue\u00f1a","sequence":"first","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, Rotenburg Heart and Vascular Centre, 36199 Rotenburg an der Fulda, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5734-6668","authenticated-orcid":false,"given":"Maximilian","family":"Vondran","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, Klinikum Karlsburg, Heart and Diabetes Center Mecklenburg-Western Pommerania, 17495 Carlsburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Irqsusi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Marburg University Hospital, Philipps University of Marburg, Baldingerstrasse, 35043 Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Nef","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rotenburg Heart and Vascular Centre, 36199 Rotenburg an der Fulda, Germany"},{"name":"Department of Cardiology, Giessen University Hospital, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ardawan","family":"Rastan","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, Rotenburg Heart and Vascular Centre, 36199 Rotenburg an der Fulda, Germany"},{"name":"Department of Cardiac Surgery, Marburg University Hospital, Philipps University of Marburg, Baldingerstrasse, 35043 Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2413-4065","authenticated-orcid":false,"given":"Tamer","family":"Ghazy","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Marburg University Hospital, Philipps University of Marburg, Baldingerstrasse, 35043 Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jtcvs.2010.08.033","article-title":"Results of mitral valve repair for Barlow disease (bileaflet prolapse) via right minithoracotomy versus conventional median sternotomy: A randomized trial","volume":"142","author":"Speziale","year":"2011","journal-title":"J. Thorac. Cardiovasc Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.athoracsur.2004.08.066","article-title":"Minimally invasive port access versus conventional mitral valve surgery: Prospective randomized study","volume":"79","author":"Dogan","year":"2005","journal-title":"Ann. Thorac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/ejcts\/ezy289","article-title":"2018 ESC\/EACTS Guidelines on myocardial revascularization","volume":"55","author":"Neumann","year":"2019","journal-title":"Eur. J. Cardio-Thoracic Surg."},{"key":"ref_4","unstructured":"Cohen, L.H. (2008). Cardiac Sugery in the Adult, McGraw-Hill. [3rd ed.]."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000357263","article-title":"Three-year results of repaired Barlow mitral valves via right minithoracotomy versus median sternotomy in a randomized trial","volume":"128","author":"Nasso","year":"2014","journal-title":"Cardiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1055\/s-0036-1592124","article-title":"German Heart Surgery Report 2015: The Annual Updated Registry of the German Society for Thoracic and Cardiovascular Surgery","volume":"64","author":"Beckmann","year":"2016","journal-title":"Thorac. Cardiovasc Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1055\/s-0037-1606603","article-title":"German heart surgery report 2016: The annual updated registry of the German society, for thoracic and cardiovascular surgery","volume":"65","author":"Beckmann","year":"2017","journal-title":"Thorac. Cardiovasc Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1055\/s-0038-1676131","article-title":"German heart surgery report 2017: The annual updated registry of the German society for thoracic and cardiovascular surgery","volume":"66","author":"Beckmann","year":"2018","journal-title":"Thorac. Cardiovasc Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1055\/s-0039-1693022","article-title":"German heart surgery report 2018: The annual updated registry of the German society for thoracic and cardiovascular surgery","volume":"67","author":"Beckmann","year":"2019","journal-title":"Thorac. Cardiovasc Surgeon."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.21037\/jtd.2017.06.29","article-title":"Hybrid approach of percutaneous coronary intervention followed by minimally invasive mitral valve surgery: A 5-year single-center experience","volume":"9","author":"Santana","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/j.athoracsur.2014.02.039","article-title":"Hybrid approach of percutaneous coronary intervention followed by minimally invasive valve operations","volume":"97","author":"Santana","year":"2014","journal-title":"Ann. Thorac. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/CIRCINTERVENTIONS.110.957951","article-title":"Surgical update hybrid procedures, do they have a role?","volume":"3","author":"Leacche","year":"2010","journal-title":"Circ. Cardiovasc Interv."},{"key":"ref_14","first-page":"394","article-title":"Percutaneous coronary intervention followed by minimally invasive mitral valve surgery in ischemic mitral regurgitation","volume":"10","author":"Mihos","year":"2015","journal-title":"Innov. Technol. Tech. Cardio-Thorac. Vasc. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/ejcts\/ezw149","article-title":"Coronary artery bypass grafting-related bleeding complications in patients treated with dual antiplatelet treatment","volume":"50","author":"Schotborgh","year":"2016","journal-title":"Eur. J. CardioThorac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/eurheartj\/ehv381","article-title":"Coronary artery bypass grafting-related bleeding complications in patients treated with ticagrelor or clopidogrel: A nationwide study","volume":"37","author":"Hansson","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jacc.2012.03.030","article-title":"Mortality benefit with prasugrel in the TRITON-TIMI 38 coronary artery bypass grafting cohort: Risk-adjusted retrospective data analysis","volume":"60","author":"Smith","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jacc.2010.10.029","article-title":"Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery results from the PLATO (Platelet Inhibition and Patient Outcomes) trial","volume":"57","author":"Held","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/01.CIR.0000140675.85342.1B","article-title":"\u2018Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: The Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial","volume":"110","author":"Fox","year":"2004","journal-title":"Circulation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ejcts.2008.03.031","article-title":"On- and off-pump coronary surgery and perioperative myocardial infarction: An issue between incomplete and extensive revascularization","volume":"34","author":"Alamanni","year":"2008","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_21","first-page":"463","article-title":"Incomplete revascularization: What the surgeon needs to know","volume":"7","author":"Leviner","year":"2018","journal-title":"Ann. Cardio-Thorac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/ejcts\/ezx334","article-title":"2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS","volume":"53","author":"Valgimigli","year":"2018","journal-title":"Eur. J. Cardio-Thorac. 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