{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:02:14Z","timestamp":1791259334614,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background and purpose: Sporadic cerebral amyloid angiopathy (CAA) is a small vessel disease, resulting from progressive amyloid-\u03b2 deposition in the media\/adventitia of cortical and leptomeningeal arterioles. We sought to assess the prevalence of baseline characteristics, clinical and radiological findings, as well as outcomes among patients with CAA, in the largest study to date conducted in Greece. Methods: Sixty-eight patients fulfilling the Boston Criteria v1.5 for probable\/possible CAA were enrolled and followed for at least twelve months. Magnetic Resonance Imaging was used to assess specific neuroimaging markers. Data regarding cerebrospinal fluid biomarker profile and Apolipoprotein-E genotype were collected. Multiple logistic regression analyses were performed to identify predictors of clinical phenotypes. Cox-proportional hazard regression models were used to calculate associations with the risk of recurrent intracerebral hemorrhage (ICH). Results: Focal neurological deficits (75%), cognitive decline (57%), and transient focal neurological episodes (TFNEs; 21%) were the most common clinical manifestations. Hemorrhagic lesions, including lobar cerebral microbleeds (CMBs; 93%), cortical superficial siderosis (cSS; 48%), and lobar ICH (43%) were the most prevalent neuroimaging findings. cSS was independently associated with the likelihood of TFNEs at presentation (OR: 4.504, 95%CI:1.258\u201319.088), while multiple (&gt;10) lobar CMBs were independently associated with cognitive decline at presentation (OR:5.418, 95%CI:1.316\u201328.497). cSS emerged as the only risk factor of recurrent ICH (HR:4.238, 95%CI:1.509\u201311.900) during a median follow-up of 20 months. Conclusions: cSS was independently associated with TFNEs at presentation and ICH recurrence at follow-up, while a higher burden of lobar CMBs with cognitive decline at baseline. These findings highlight the prognostic value of neuroimaging markers, which may influence clinical decision-making.<\/jats:p>","DOI":"10.3390\/jcm12175591","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:10:22Z","timestamp":1693203022000},"page":"5591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Characteristics, Neuroimaging Markers, and Outcomes in Patients with Cerebral Amyloid Angiopathy: A Prospective Cohort Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-2610","authenticated-orcid":false,"given":"Aikaterini","family":"Theodorou","sequence":"first","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7757-609X","authenticated-orcid":false,"given":"Lina","family":"Palaiodimou","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Papagiannopoulou","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8317-6428","authenticated-orcid":false,"given":"Odysseas","family":"Kargiotis","sequence":"additional","affiliation":[{"name":"Stroke Unit, Metropolitan Hospital, 18547 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3993-2545","authenticated-orcid":false,"given":"Klearchos","family":"Psychogios","sequence":"additional","affiliation":[{"name":"Stroke Unit, Metropolitan Hospital, 18547 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9630-6949","authenticated-orcid":false,"given":"Apostolos","family":"Safouris","sequence":"additional","affiliation":[{"name":"Stroke Unit, Metropolitan Hospital, 18547 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7002-9795","authenticated-orcid":false,"given":"Eleni","family":"Bakola","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Chondrogianni","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Kotsali-Peteinelli","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3224-3053","authenticated-orcid":false,"given":"Konstantinos","family":"Melanis","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Tsibonakis","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissavet","family":"Andreadou","sequence":"additional","affiliation":[{"name":"First Department of Neurology, \u201cEginition\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Vasilopoulou","sequence":"additional","affiliation":[{"name":"First Department of Neurology, \u201cEginition\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanos","family":"Lachanis","sequence":"additional","affiliation":[{"name":"Iatropolis Magnetic Resonance Diagnostic Centre, 15231 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0050-284X","authenticated-orcid":false,"given":"Georgios","family":"Velonakis","sequence":"additional","affiliation":[{"name":"Second Department of Radiology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Tzavellas","sequence":"additional","affiliation":[{"name":"First Department of Psychiatry, \u201cAiginition\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Tzartos","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Voumvourakis","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2481-3060","authenticated-orcid":false,"given":"Georgios P.","family":"Paraskevas","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-3797","authenticated-orcid":false,"given":"Georgios","family":"Tsivgoulis","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"},{"name":"Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/brain\/awx047","article-title":"Emerging concepts in sporadic cerebral amyloid angiopathy","volume":"140","author":"Charidimou","year":"2017","journal-title":"Brain"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Keage, H.A., Carare, R.O., Friedland, R.P., Ince, P.G., Love, S., Nicoll, J.A., Wharton, S.B., Weller, R.O., and Brayne, C. (2009). Population studies of sporadic cerebral amyloid angiopathy and dementia: A systematic review. BMC Neurol., 9.","DOI":"10.1186\/1471-2377-9-3"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s007020200068","article-title":"Alzheimer disease and cerebrovascular pathology: An update","volume":"109","author":"Jellinger","year":"2002","journal-title":"J. Neural Transm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1212\/WNL.56.4.537","article-title":"Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston criteria","volume":"56","author":"Knudsen","year":"2001","journal-title":"Neurology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1212\/WNL.0b013e3181dad605","article-title":"Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy","volume":"74","author":"Linn","year":"2010","journal-title":"Neurology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S1474-4422(22)00208-3","article-title":"The Boston criteria version 2.0 for cerebral amyloid angiopathy: A multicentre, retrospective, MRI-neuropathology diagnostic accuracy study","volume":"21","author":"Charidimou","year":"2022","journal-title":"Lancet Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1161\/STROKEAHA.120.031471","article-title":"Prevalence, characteristics, and outcomes of undetermined intracerebral hemorrhage: A systematic review and meta-analysis","volume":"52","author":"Malhotra","year":"2021","journal-title":"Stroke"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e792","DOI":"10.1212\/WNL.0000000000006956","article-title":"Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy","volume":"92","author":"Wollenweber","year":"2019","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1161\/STROKEAHA.121.035836","article-title":"Prevalence of Clinical and Neuroimaging Markers in Cerebral Amyloid Angiopathy: A Systematic Review and Meta-Analysis","volume":"53","author":"Malhotra","year":"2022","journal-title":"Stroke"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/jnnp-2020-323951","article-title":"Cerebral microbleeds: From depiction to interpretation","volume":"92","author":"Puy","year":"2021","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1212\/WNL.0000000000003184","article-title":"Microbleeds on MRI are associated with microinfarcts on autopsy in cerebral amyloid angiopathy","volume":"87","author":"Lauer","year":"2016","journal-title":"Neurology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1212\/WNL.0000000000002362","article-title":"White matter hyperintensity patterns in cerebral amyloid angiopathy and hypertensive arteriopathy","volume":"86","author":"Charidimou","year":"2016","journal-title":"Neurology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e554","DOI":"10.1212\/WNL.0000000000010017","article-title":"White matter atrophy in cerebral amyloid angiopathy","volume":"95","author":"Fotiadis","year":"2020","journal-title":"Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/ana.21694","article-title":"Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy","volume":"66","author":"Verbeek","year":"2009","journal-title":"Ann. Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1212\/WNL.0000000000005030","article-title":"Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis","volume":"90","author":"Charidimou","year":"2018","journal-title":"Neurology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/ana.26610","article-title":"Decreased Cerebrospinal Fluid Amyloid \u03b2 38, 40, 42, and 43 Levels in Sporadic and Hereditary Cerebral Amyloid Angiopathy","volume":"93","author":"Kuiperij","year":"2023","journal-title":"Ann. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e358","DOI":"10.1212\/WNL.0000000000007818","article-title":"APOE and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms","volume":"93","author":"Charidimou","year":"2019","journal-title":"Neurology"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Vandenbroucke, J.P., von Elm, E., Altman, D.G., G\u00f8tzsche, P.C., Mulrow, C.D., Pocock, S.J., Poole, C., Schlesselman, J.J., and Egger, M. (2007). STROBE Initiative. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration. PLoS Med., 4.","DOI":"10.1371\/journal.pmed.0040297"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"Standards for ReportIng Vascular changes on nEuroimaging (STRIVE v1). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1.5 T in Alzheimer\u2019s dementia and normal aging","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1212\/WNL.0000000000003746","article-title":"MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy","volume":"88","author":"Charidimou","year":"2017","journal-title":"Neurology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1161\/STROKEAHA.109.548974","article-title":"Microbleeds versus macrobleeds: Evidence for distinct entities","volume":"40","author":"Greenberg","year":"2009","journal-title":"Stroke"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v049.i05","article-title":"Closing the gap between methodologists and end-users: R as a computational back-end","volume":"49","author":"Wallace","year":"2012","journal-title":"J. Stat. Softw."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/ana.20596","article-title":"Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy","volume":"58","author":"Rosand","year":"2005","journal-title":"Ann. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1212\/WNL.0000000000012234","article-title":"Cerebral Amyloid Angiopathy\u2013Related Transient Focal Neurologic Episodes","volume":"97","author":"Smith","year":"2021","journal-title":"Neurology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1161\/STROKEAHA.122.041395","article-title":"Cortical Superficial Siderosis and Transient Focal Neurological Episode Preceding Lobar Hemorrhage in Cerebral Amyloid Angiopathy","volume":"54","author":"Theodorou","year":"2023","journal-title":"Stroke"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1001\/jamaneurol.2021.3989","article-title":"Transient focal neurological events in cerebral amyloid angiopathy and the longterm risk of intracerebral hemorrhage and death: A systematic review and metaanalysis","volume":"79","author":"Ubago","year":"2022","journal-title":"JAMA Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e2192","DOI":"10.1212\/WNL.0000000000008590","article-title":"Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy: A meta-analysis","volume":"93","author":"Charidimou","year":"2019","journal-title":"Neurology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1161\/STROKEAHA.116.012999","article-title":"Cerebral Amyloid Angiopathy Is Associated with Executive Dysfunction and Mild Cognitive Impairment","volume":"47","author":"Case","year":"2016","journal-title":"Stroke"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3233\/JAD-150890","article-title":"Cognitive Profile and its Association with Neuroimaging Markers of Non-Demented Cerebral Amyloid Angiopathy Patients in a Stroke Unit","volume":"52","author":"Xiong","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1161\/STROKEAHA.118.022280","article-title":"Cerebral Cortical Microinfarcts on Magnetic Resonance Imaging and Their Association With Cognition in Cerebral Amyloid Angiopathy","volume":"49","author":"Xiong","year":"2018","journal-title":"Stroke"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3233\/JAD-190346","article-title":"Predictors for Late Post-Intracerebral Hemorrhage Dementia in Patients with Probable Cerebral Amyloid Angiopathy","volume":"71","author":"Xiong","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"783996","DOI":"10.3389\/fnagi.2022.783996","article-title":"Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy: New Data and Quantitative Meta-Analysis","volume":"14","author":"Margraf","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/d41586-023-00030-3","article-title":"FDA approves Alzheimer\u2019s drug lecanemab amid safety concerns","volume":"613","author":"Reardon","year":"2023","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer disease \u2014 one peptide, two pathways","volume":"16","author":"Greenberg","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"720","DOI":"10.2214\/AJR.07.2249","article-title":"MRI of cerebral microhemorrhages","volume":"189","author":"Blitstein","year":"2007","journal-title":"Am. J. Roentgenol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/jon.13072","article-title":"Cerebral cavernous malformations: Typical and atypical imaging characteristics","volume":"33","author":"Kuroedov","year":"2023","journal-title":"J. Neuroimaging"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/WNL.0000000000001223","article-title":"High-resolution MRI of radiation-induced intracranial vasculopathy","volume":"84","author":"Li","year":"2015","journal-title":"Neurology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00234-021-02839-z","article-title":"The radiological interpretation of possible microbleeds after moderate or severe traumatic brain injury: A longitudinal study","volume":"64","author":"Maas","year":"2022","journal-title":"Neuroradiology"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Di Donato, I., Bianchi, S., De Stefano, N., Dichgans, M., Dotti, M.T., Duering, M., Jouvent, E., Korczyn, A.D., Lesnik-Oberstein, S.A.J., and Malandrini, A. (2017). Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: Update on clinical, diagnostic, and management aspects. BMC Med., 15.","DOI":"10.1186\/s12916-017-0778-8"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e513","DOI":"10.1161\/STROKEAHA.110.581918","article-title":"COL4A1 mutations as a monogenic cause of cerebral small vessel disease: A systematic review","volume":"41","author":"Lanfranconi","year":"2010","journal-title":"Stroke"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/STROKEAHA.122.040671","article-title":"Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis","volume":"54","author":"Theodorou","year":"2023","journal-title":"Stroke"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e1809","DOI":"10.1212\/WNL.0000000000012778","article-title":"Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study","volume":"97","author":"Antolini","year":"2021","journal-title":"Neurology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/jnnp-2012-303898","article-title":"Genetics of cerebral amyloid angiopathy: Systematic review and meta-analysis","volume":"84","author":"Samarasekera","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/17\/5591\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:40:08Z","timestamp":1760128808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/17\/5591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,27]]},"references-count":45,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["jcm12175591"],"URL":"https:\/\/doi.org\/10.3390\/jcm12175591","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,27]]}}}