{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:45:07Z","timestamp":1790372707043,"version":"4.1.0"},"reference-count":46,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Eufoton S.R.L.\u00ae","award":["23\/1-34148"],"award-info":[{"award-number":["23\/1-34148"]}]},{"name":"Eufoton S.R.L.\u00ae","award":["TS 114755"],"award-info":[{"award-number":["TS 114755"]}]},{"name":"Eufoton S.R.L.\u00ae","award":["03013"],"award-info":[{"award-number":["03013"]}]},{"name":"Eufoton S.R.L.\u00ae","award":["B-42553602"],"award-info":[{"award-number":["B-42553602"]}]},{"name":"REA","award":["23\/1-34148"],"award-info":[{"award-number":["23\/1-34148"]}]},{"name":"REA","award":["TS 114755"],"award-info":[{"award-number":["TS 114755"]}]},{"name":"REA","award":["03013"],"award-info":[{"award-number":["03013"]}]},{"name":"REA","award":["B-42553602"],"award-info":[{"award-number":["B-42553602"]}]},{"name":"Benuren Women S.L.\u00ae\/Dr. Sapena 8, Bajo Izquierda","award":["23\/1-34148"],"award-info":[{"award-number":["23\/1-34148"]}]},{"name":"Benuren Women S.L.\u00ae\/Dr. Sapena 8, Bajo Izquierda","award":["TS 114755"],"award-info":[{"award-number":["TS 114755"]}]},{"name":"Benuren Women S.L.\u00ae\/Dr. Sapena 8, Bajo Izquierda","award":["03013"],"award-info":[{"award-number":["03013"]}]},{"name":"Benuren Women S.L.\u00ae\/Dr. Sapena 8, Bajo Izquierda","award":["B-42553602"],"award-info":[{"award-number":["B-42553602"]}]},{"name":"CIF","award":["23\/1-34148"],"award-info":[{"award-number":["23\/1-34148"]}]},{"name":"CIF","award":["TS 114755"],"award-info":[{"award-number":["TS 114755"]}]},{"name":"CIF","award":["03013"],"award-info":[{"award-number":["03013"]}]},{"name":"CIF","award":["B-42553602"],"award-info":[{"award-number":["B-42553602"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: One of the side effects of anti-estrogen treatments in breast cancer survivors (BCSs), especially with aromatase inhibitor (AI) treatment, is the frequent appearance of vulvo-vaginal atrophy (VVA). We aim to evaluate the efficacy, safety and feasibility of a new type of non-ablative Solid-State Vaginal Laser (SSVL) treatment in BCSs with VVA. Methods: A total of 30 BCSs with a history of AI use and symptoms of VVA were treated with a non-ablative SSVL (LASEmaR 1500\u2122-EUFOTON)in this non-randomized pilot study. The effects of the laser have been evaluated at baseline, 10 wk and 24 wk using a visual analogue scale (VAS), the Vaginal Health Index (VHI), the Vulvar Health Index (VuHI), the Female Sexual Function Index (FSFI), the EORTC QLQ-BR23, the Vaginal Maturation Index (VMI) and vaginal pH. Results: At 10-week follow-up vs. baseline there were no statistically significant differences in FSFI, lubrication and EORTC QLQ-BR23. In all the subjective (dyspareunia, VHI, VuHI, FSFI, QLQ) and objective parameters (VMI and pH) there was a statistically significant improvement at the 6-month follow-up. Satisfaction was very high (4.7 out of 5), with 95.7% of patients being satisfied, more than or very satisfied. Conclusions: Preliminary results of SSVL treatment of VVA and dyspareunia in BCSs after AI treatment suggest clinical improvement, without relevant side effects and with a high degree of satisfaction<\/jats:p>","DOI":"10.3390\/jcm12175669","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:41:18Z","timestamp":1693482078000},"page":"5669","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Non-Ablative Solid-State Vaginal Laser (SSVL) for the Treatment of Vulvovaginal Atrophy in Breast Cancer Survivors after Adjuvant Aromatase Inhibitor Therapy: Preliminary Results"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-1751","authenticated-orcid":false,"given":"Daniel M.","family":"Lubi\u00e1n-L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital of Jerez de la Frontera, 11407 C\u00e1diz, Spain"},{"name":"Department of Obstetrics and Gynecology, Viamed Bah\u00eda de C\u00e1diz Hospital, 11130 C\u00e1diz, Spain"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of C\u00e1diz, 11003 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen A.","family":"Butr\u00f3n-Hinojo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital of Jerez de la Frontera, 11407 C\u00e1diz, Spain"},{"name":"Department of Obstetrics and Gynecology, Viamed Bah\u00eda de C\u00e1diz Hospital, 11130 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00f3n","family":"Menj\u00f3n-Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Regional University Hospital of Granada and Inagor Women\u2019s Clinic, 18001 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-092X","authenticated-orcid":false,"given":"Ernesto","family":"Gonz\u00e1lez-Mesa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Regional University Hospital of M\u00e1laga, 29001 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Tapiador-Albertos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Alboran CMM Women\u2019s Clinic, 04001 Almer\u00eda, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibiana","family":"Rodr\u00edguez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Alboran CMM Women\u2019s Clinic, 04001 Almer\u00eda, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3819-6742","authenticated-orcid":false,"given":"Gabriel","family":"Fiol-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Alboran CMM Women\u2019s Clinic, 04001 Almer\u00eda, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1097\/GME.0000000000000329","article-title":"Vulvovaginal Atrophy Terminology Consensus Conference Panel. Genitourinary syndrome of menopause: New terminology for vulvovaginal atrophy from the International Society for the Study of Women\u2019s Sexual Health and the North. American Menopause Society","volume":"21","author":"Portman","year":"2014","journal-title":"Menopause"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ajog.2016.07.045","article-title":"Genitourinary syndrome of menopause: An overview of clinical manifestations, pathophysiology, etiology, evaluation, and management","volume":"215","author":"Gandhi","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1200\/JCO.2004.08.029","article-title":"Quality of life of postmenopausal women in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Adjuvant Breast Cancer Trial","volume":"22","author":"Fallowfield","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/cncr.11126","article-title":"The biology of breast carcinoma","volume":"97","author":"Keen","year":"2003","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/GME.0b013e3182976f46","article-title":"Nature and severity of menopausal symptoms and their impact on quality of life and sexual function in cancer survivors compared with women without a cancer history","volume":"21","author":"Marino","year":"2014","journal-title":"Menopause"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.clbc.2017.05.008","article-title":"Vaginal Atrophy in Breast Cancer Survivors: Attitude and Approaches Among Oncologists","volume":"17","author":"Biglia","year":"2017","journal-title":"Clin. Breast. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3109\/13697137.2011.647840","article-title":"Vaginal Health: Insights, Views & Attitudes (VIVA)\u2014Results from an international survey","volume":"15","author":"Nappi","year":"2012","journal-title":"Climacteric"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s12282-015-0655-2","article-title":"The pharmacological and hormonal therapy of hot flushes in breast cancer survivors","volume":"23","author":"Jochymek","year":"2016","journal-title":"Breast Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/S0140-6736(02)09088-8","article-title":"ATAC Trialists\u2019 Group. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: First results of the ATAC randomised trial","volume":"359","author":"Baum","year":"2002","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2010.08.035","article-title":"Urogenital disorders in women with adjuvant endocrine therapy after early breast cancer","volume":"204","author":"Baumgart","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_12","first-page":"376","article-title":"Sexual Dysfunction in Postmenopausal Women with Breast Cancer on Adjuvant Aromatase Inhibitor Therapy","volume":"16","author":"Mendoza","year":"2020","journal-title":"Breast Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2147\/IJWH.S158913","article-title":"Current treatment options for postmenopausal vaginal atrophy","volume":"10","author":"Naumova","year":"2018","journal-title":"Int. J. Womens Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(04)15493-7","article-title":"HABITS steering and data monitoring committees. HABITS (hormonal replacement therapy after breast cancer--is it safe?), a randomised comparison: Trial stopped","volume":"363","author":"Holmberg","year":"2004","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1073\/pnas.98.1.142","article-title":"Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF\/granulin precursor)","volume":"98","author":"Lu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5306\/wjco.v13.i2.71","article-title":"Management of genitourinary syndrome of menopause in breast cancer survivors: An update","volume":"13","year":"2022","journal-title":"World J. Clin. Oncol."},{"key":"ref_17","unstructured":"(2018, August 02). FDA Warns Against Use of Energy-Based Devices to Perform Vaginal \u2018Rejuvenation\u2019 or Vaginal Cosmetic Procedures: FDA Safety Communication, Available online: https:\/\/www.fda.gov\/MedicalDevices\/Safety\/AlertsandNotices\/ucm615013.htm."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Elective Female Genital Cosmetic Surgery (2020). ACOGCommitee Opinion No. 795. American College of Obstetricians and Gynecologists. Obstet. Gynecol., 135, e36\u2013e42.","DOI":"10.1097\/AOG.0000000000003616"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/SPV.0000000000000872","article-title":"Vaginal Energy-Based Devices","volume":"26","author":"Alshiek","year":"2020","journal-title":"Female Pelvic. Med. Reconstr. Surg."},{"key":"ref_20","first-page":"3","article-title":"Long-term non-hormonal treatment of vaginal dryness","volume":"8","author":"Bachmann","year":"1992","journal-title":"Clin. Pr. Sex."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/13697137.2016.1262840","article-title":"Vulvar and vaginal atrophy as viewed by the Spanish REVIVE participants: Symptoms, management and treatment perceptions","volume":"20","author":"Palacios","year":"2017","journal-title":"Climacteric"},{"key":"ref_22","first-page":"249","article-title":"The maturation value","volume":"11","author":"Meisels","year":"1967","journal-title":"Acta Cytol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ajog.2003.12.015","article-title":"Vaginal pH is similar to follicle stimulating hormone for menopause diagnosis","volume":"190","author":"Roy","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/009262300278597","article-title":"The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function","volume":"26","author":"Rosen","year":"2000","journal-title":"J. Sex. Marital. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1002\/cncr.26739","article-title":"Psychometric validation of the Female Sexual Function Index (FSFI) in cancer survivors","volume":"118","author":"Baser","year":"2012","journal-title":"Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1200\/JCO.1996.14.10.2756","article-title":"The European Organisation for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: First results from a three-country field study","volume":"10","author":"Sprangers","year":"1996","journal-title":"J. Clin. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.maturitas.2015.08.001","article-title":"Genitourinary syndrome of menopause and the use of laser therapy","volume":"82","author":"Segal","year":"2015","journal-title":"Maturitas"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1097\/GME.0000000000001845","article-title":"Vaginal CO2 laser therapy versus sham for genitourinary syndrome of menopause management: A systematic review and meta-analysis of randomized controlled trials","volume":"28","author":"Khamis","year":"2021","journal-title":"Menopause"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.maturitas.2020.10.018","article-title":"Pilot study of fractional CO2 laser therapy for genitourinary syndrome of menopause in gynecologic cancer survivors","volume":"144","author":"Quick","year":"2021","journal-title":"Maturitas"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jsxm.2021.12.010","article-title":"CO2-Laser therapy and Genitourinary Syndrome of Menopause: A Systematic Review and Meta-Analysis","volume":"19","author":"Filippini","year":"2022","journal-title":"J. Sex Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Quick, A.M., Hundley, A., Evans, C., Stephens, J.A., Ramaswamy, B., Reinbolt, R.E., Noonan, A.M., Van Deusen, J.B., Wesolowski, R., and Stover, D.G. (2022). Long-Term Follow-Up of Fractional CO2 Laser Therapy for Genitourinary Syndrome of Menopause in Breast Cancer Survivors. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030774"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e539","DOI":"10.1016\/j.clbc.2021.01.006","article-title":"Microablative Fractional CO2 Laser for Vulvovaginal Atrophy in Women With a History of Breast Cancer: A Pilot Study at 4-week Follow-up","volume":"21","author":"Salvatore","year":"2021","journal-title":"Clin. Breast Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10103-019-02855-9","article-title":"Intravaginal energy-based devices and sexual health of female cancer survivors: A systematic review and meta-analysis","volume":"35","author":"Athanasiou","year":"2020","journal-title":"Lasers Med. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.maturitas.2022.08.013","article-title":"Vaginal laser therapy versus hyaluronic acid suppositories for women with symptoms of urogenital atrophy after treatment for breast cancer: A randomized controlled trial","volume":"167","author":"Gold","year":"2023","journal-title":"Maturitas"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e2255697","DOI":"10.1001\/jamanetworkopen.2022.55697","article-title":"Effect of Fractional Carbon Dioxide vs Sham Laser on Sexual Function in Survivors of Breast Cancer Receiving Aromatase Inhibitors for Genitourinary Syndrome of Menopause: The LIGHT Randomized Clinical Trial","volume":"6","author":"Mension","year":"2023","journal-title":"JAMA Netw. Open."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.maturitas.2017.06.029","article-title":"Laser therapy for the genitourinary syndrome of menopause. A systematic review and meta-analysis","volume":"103","author":"Pitsouni","year":"2017","journal-title":"Maturitas"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.31083\/j.ceog5002040","article-title":"Treatment of Female Sexual Dysfunction Due to Dyspareunia with Solid-State Vaginal Laser and Recombinant Platelet-Derived Epidermal Growth Factors: A Viable Possibility?","volume":"50","author":"Mendoza","year":"2023","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4236\/ojog.2018.82015","article-title":"Solid State Vaginal Laser for the Treatment of Genitourinary Syndrome of Menopause: A Preliminary Report","volume":"8","author":"Dodero","year":"2018","journal-title":"Open J. Obstet. Gynecol."},{"key":"ref_39","first-page":"99","article-title":"Histological Modifications of Postmenopausal Vaginal Mucosa after Regenerative Solid State Laser Treatment: A Multicenter Study","volume":"5","author":"Dodero","year":"2019","journal-title":"Int. J. Womens Health Wellness"},{"key":"ref_40","first-page":"253","article-title":"Ladylift\u00ae non-ablative laser technology for the treatment of menopausal vestibulodynia and genitourinary syndrome","volume":"21","author":"Stabile","year":"2022","journal-title":"PrzMenopauzalny"},{"key":"ref_41","first-page":"99","article-title":"Genitourinary Syndrome of Menopause Assessment Tools","volume":"12","author":"Mension","year":"2021","journal-title":"J. Midlife Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10549-021-06226-3","article-title":"Effects of local laser treatment on vulvovaginal atrophy among women with breast cancer: A prospective study with long-term follow-up","volume":"188","author":"Veron","year":"2021","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3109\/13697137.2010.522875","article-title":"Recommendations for the management of postmenopausal vaginal atrophy","volume":"13","author":"Sturdee","year":"2010","journal-title":"Climacteric"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.jsxm.2019.08.019","article-title":"Dyspareunia Related to GSM: Association of Total Vaginal Thickness via Transabdominal Ultrasound","volume":"16","author":"Balica","year":"2019","journal-title":"J. Sex Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1080\/13697137.2016.1212006","article-title":"The effect of microablative fractional CO2 laser on vaginal flora of postmenopausal women","volume":"19","author":"Athanasiou","year":"2016","journal-title":"Climacteric"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Sipos, A.G., P\u00e1kozdy, K., J\u00e4ger, S., Larson, K., Takacs, P., and Kozma, B. (2021). Fractional CO2 laser treatment effect on cervicovaginallavage zinc and copper levels: A prospective cohort study. BMC Womens Health, 21.","DOI":"10.1186\/s12905-021-01379-1"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/17\/5669\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:43:43Z","timestamp":1760129023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/17\/5669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,31]]},"references-count":46,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["jcm12175669"],"URL":"https:\/\/doi.org\/10.3390\/jcm12175669","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,31]]}}}