{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:01:58Z","timestamp":1787688118505,"version":"build-2784847793"},"reference-count":35,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Hypertrophic cardiomyopathy (HCM) is a complex disorder that includes various phenotypes, leading to different manifestations. It also shares different disadvantages typical of rare diseases, including limited recognition, lack of prospective studies assessing treatment, and little or delayed access to advanced treatment options. Reliable data about the prevalence and natural history of cardiomyopathies in South America are lacking. This study summarizes the features and management of patients with HCM in a university hospital in Colombia. Methods: This was an observational retrospective cohort study of patients with HCM between January 2010 and December 2021. Patient data were analyzed from an institutional cardiomyopathy registry. Demographic, paraclinical, and outcome data were collected. Results: A total of 82 patients during the study period were enrolled. Of these, 67.1% were male, and the mean age at diagnosis was 49 years. Approximately 83% were in NYHA functional class I and II, and the most reported symptoms were dyspnea (38%), angina (20%), syncope (15%), and palpitations (11%). In addition, 89% had preserved left ventricular ejection fraction (LVEF) with an asymmetric septal pattern in 65%. Five patients (6%) had alcohol septal ablation and four (5%) had septal myectomy. One patient required heart transplantation during follow-up. Sudden cardiovascular death was observed in 2.6%. The overall mortality during follow-up was 7.3%. Conclusions: HCM is a complex and heterogeneous disorder that presents with significant morbidity and mortality. Our registry provides comprehensive data on disease courses and management in a developing country.<\/jats:p>","DOI":"10.3390\/jcm12175682","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:41:18Z","timestamp":1693482078000},"page":"5682","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypertrophic Cardiomyopathy in a Latin American Center: A Single Center Observational Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Juan David","family":"L\u00f3pez-Ponce de Leon","sequence":"first","affiliation":[{"name":"Departamento de Cardiolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-2508","authenticated-orcid":false,"given":"Mayra","family":"Estacio","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Giraldo","sequence":"additional","affiliation":[{"name":"Departamento de Cardiolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Escalante","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorlany","family":"Rodas","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Largo","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Lores","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Camila","family":"Victoria","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Argote","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Florez","sequence":"additional","affiliation":[{"name":"Departamento de Cardiolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Departamento de Cardiolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pastor","family":"Olaya","sequence":"additional","affiliation":[{"name":"Departamento de Cardiolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Mejia","sequence":"additional","affiliation":[{"name":"Departamento de Radiolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Esteban","family":"Gomez","sequence":"additional","affiliation":[{"name":"Departamento de Cardiolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur. 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