{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:51:24Z","timestamp":1792806684053,"version":"4.5.0"},"reference-count":27,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The aim of this multicenter retrospective cohort study was to examine the impact of maternal age on perinatal outcomes in multiparas, stratified according to maternal age in one- and two-year increments. The analysis involved 302,484 multiparas who delivered between the years 2003 and 2021 in four university-affiliated obstetrics departments. Maternal age was considered both as a continuous variable and in two-year intervals, as compared with a comparison group of parturients aged 25\u201330 years. The study focused on cesarean delivery and neonatal intensive care unit (NICU) admission as primary outcomes. The findings revealed that cesarean delivery rates increased as maternal age advanced, with rates ranging from 6.7% among 25\u201330 year olds, rising continuously from 13.5% to 19.9% between the age strata of 31 and 42, to exceeding 20% among those aged \u2265 43 years (p &lt; 0.01 for each stratum when compared to 25\u201330 year old group). Similarly, NICU admission rates rose from 2.7% in the comparison group to 6% in parturients aged 45\u201346 years (p &lt; 0.01 for each stratum when compared to 25\u201330 year old group). The study highlights the association between incrementally advanced maternal age and increased rates of maternal and neonatal complications, necessitating global awareness of these implications for family planning decisions and maternal care.<\/jats:p>","DOI":"10.3390\/jcm12175696","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T09:12:22Z","timestamp":1693559542000},"page":"5696","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The Impact of Advanced Maternal Age on Pregnancy Outcomes: A Retrospective Multicenter Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Hila","family":"Hochler","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hadassah Medical Center Mount-Scopus, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9765422, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7370-0417","authenticated-orcid":false,"given":"Michal","family":"Lipschuetz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hadassah Medical Center Mount-Scopus, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9765422, Israel"},{"name":"Henrietta Szold School of Nursing, Faculty of Medicine, Hadassah and the Hebrew University, Jerusalem 91120, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Suissa-Cohen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hadassah Medical Center Mount-Scopus, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9765422, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Shaare Zedek Medical Center, Faculty of Medicine, Affiliated with the Hebrew University School of Medicine, Jerusalem 91031, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9859-469X","authenticated-orcid":false,"given":"Hen Y.","family":"Sela","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Shaare Zedek Medical Center, Faculty of Medicine, Affiliated with the Hebrew University School of Medicine, Jerusalem 91031, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simcha","family":"Yagel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hadassah Medical Center Mount-Scopus, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9765422, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua I.","family":"Rosenbloom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hadassah Medical Center Ein-Kerem, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91121, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorina","family":"Grisaru-Granovsky","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Shaare Zedek Medical Center, Faculty of Medicine, Affiliated with the Hebrew University School of Medicine, Jerusalem 91031, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4875-1455","authenticated-orcid":false,"given":"Misgav","family":"Rottenstreich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Shaare Zedek Medical Center, Faculty of Medicine, Affiliated with the Hebrew University School of Medicine, Jerusalem 91031, Israel"},{"name":"Department of Nursing, Jerusalem College of Technology, Jerusalem 9548301, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"ref_1","first-page":"n2","article-title":"Births: Final data for 2001","volume":"51","author":"Martin","year":"2002","journal-title":"Natl. 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