{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:59:08Z","timestamp":1783655948716,"version":"3.55.0"},"reference-count":97,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Acute optic neuritis (AON) is a common cause of sudden visual loss in young patients. Because of the risk of demyelinating disease, patients affected by unilateral or bilateral optic neuritis should be evaluated and treated accordingly. Despite advancements in imaging of the brain and retina, misdiagnosis of AON is not uncommon. Indeed, some acute disorders of the retina have the potential to mimic AON and their prompt diagnosis may avoid unnecessary neurologic investigation, psychological stress to the patient, and delays in treatment. This review describes uncommon retinal disorders presenting with sudden-onset visual loss and absent or subtle funduscopic manifestation that can mimic AON. Multimodal retinal imaging is essential in detecting these conditions and in their differential diagnosis. It behooves neurologists and general ophthalmologists to be aware of these entities and be familiar with multimodal imaging of the retina.<\/jats:p>","DOI":"10.3390\/jcm12175720","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T09:12:22Z","timestamp":1693559542000},"page":"5720","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Acute-Onset Retinal Conditions Mimicking Acute Optic Neuritis: Overview and Differential Diagnosis"],"prefix":"10.3390","volume":"12","author":[{"given":"Emanuela","family":"Interlandi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, \u201cOspedale del Mare\u201d, ASL Napoli 1-Centro, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u201cSanto Spirito\u201d Hospital, 65122 Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Giuffr\u00e8","sequence":"additional","affiliation":[{"name":"Centro Europeo di Oftalmologia, 90141 Palermo, Italy"},{"name":"Ophthalmology Department, San Raffaele Scientific Institute, University Vita-Salute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Cirone","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u201cVilla Anna\u201d Hospital, 63074 San Benedetto del Tronto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Brocca","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u201cDe Gironcoli\u201d Hospital, AULSS2 Marca Trevigiana, 31015 Conegliano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX 77030, USA"},{"name":"Departments of Ophthalmology, Neurology and Neurosurgery, Weill Cornell Medicine, New York, NY 10021, USA"},{"name":"Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX 77555, USA"},{"name":"University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"},{"name":"Texas A and M College of Medicine, Bryan, TX 77807, USA"},{"name":"Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-0740","authenticated-orcid":false,"given":"Giuseppe","family":"Casalino","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS C\u00e0 Granda, Ospedale Maggiore Policlinico, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4103\/tjo.tjo_11_20","article-title":"Acute zonal occult outer retinopathy presenting as optic neuritis","volume":"10","author":"Peng","year":"2020","journal-title":"Taiwan J. 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