{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:27:36Z","timestamp":1760149656492,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Preliminary research suggests post-traumatic stress disorder (PTSD) is a risk factor for chronic low back pain (CLBP). However, this literature displays some limitations. Therefore, this study aimed to investigate the association between PTSD and the 10-year cumulative incidence of CLBP in adults from Germany. Methods: The present retrospective cohort study included adults diagnosed with PTSD in 1 of 1284 general practices in Germany in 2005\u20132020 (index date). Individuals without PTSD were matched to those with PTSD (1:1) using a propensity score based on age, sex, index year, duration of follow-up, and the mean number of consultations during follow-up. In patients without PTSD, the index date was a randomly selected visit date. Results: There were 60,664 patients included in the study. After adjusting for frequent comorbidities, there was a positive but non-significant association between PTSD and incident CLBP in the overall population (HR = 1.07, 95% CI = 0.99\u20131.15). Nonetheless, the relationship between PTSD and CLBP was statistically significant in the age group &gt;60 years (HR = 1.24, 95% CI = 1.05\u20131.46). Conclusions: Conversely to previous research, PTSD was not associated with incident CLBP in this large German sample. Further longitudinal studies are warranted to corroborate these findings before drawing any firm conclusions.<\/jats:p>","DOI":"10.3390\/jcm12175753","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T10:24:30Z","timestamp":1693823070000},"page":"5753","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is There an Association between Post-Traumatic Stress Disorder and the Incidence of Chronic Low Back Pain?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-7227","authenticated-orcid":false,"given":"Karel","family":"Kostev","sequence":"first","affiliation":[{"name":"Epidemiology, IQVIA, 60549 Frankfurt, Germany"},{"name":"University Clinic of Philipps University, 35037 Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-9833","authenticated-orcid":false,"given":"Lee","family":"Smith","sequence":"additional","affiliation":[{"name":"Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge CB1 1PT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep Maria","family":"Haro","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Parc Sanitari Sant Joan de D\u00e9u, CIBERSAM, ISCIII, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, 08830 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6798-5092","authenticated-orcid":false,"given":"Marcel","family":"Konrad","sequence":"additional","affiliation":[{"name":"Health & Social, FOM University of Applied Sciences for Economics and Management, 45127 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-5004","authenticated-orcid":false,"given":"Ai","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Parc Sanitari Sant Joan de D\u00e9u, CIBERSAM, ISCIII, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, 08830 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-1239","authenticated-orcid":false,"given":"Louis","family":"Jacob","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Parc Sanitari Sant Joan de D\u00e9u, CIBERSAM, ISCIII, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, 08830 Barcelona, Spain"},{"name":"Universit\u00e9 Paris Cit\u00e9, AP-HP, Lariboisi\u00e8re-Fernand Widal Hospital, Physical Medicine and Rehabilitation Department, 75010 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm U1153, Epidemiology of Ageing and Neurodegenerative Diseases, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/JPR.S171729","article-title":"Chronic Low Back Pain and Postural Rehabilitation Exercise: A Literature Review","volume":"12","author":"Paolucci","year":"2019","journal-title":"J. Pain Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0034-8910.2015049005874","article-title":"Prevalence of Chronic Low Back Pain: Systematic Review","volume":"49","author":"Meucci","year":"2015","journal-title":"Rev. Saude Publica"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11940-001-0051-4","article-title":"Low Back Pain","volume":"3","author":"Bartleson","year":"2001","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12955-018-1018-4","article-title":"Chronic Back Pain and Its Association with Quality of Life in a Large French Population Survey","volume":"16","author":"Husky","year":"2018","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"E809","DOI":"10.1097\/BRS.0b013e31815cd422","article-title":"From Chronic Low Back Pain to Disability, a Multifactorial Mediated Pathway: The InCHIANTI Study","volume":"32","author":"Abate","year":"2007","journal-title":"Spine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e000569","DOI":"10.1136\/bmjdrc-2018-000569","article-title":"Is Chronic Low Back Pain a Risk Factor for Diabetes? The Nord-Tr\u00f8ndelag Health Study","volume":"6","author":"Heuch","year":"2018","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Fernandez, M., Ordo\u00f1ana, J.R., Hartvigsen, J., Ferreira, M.L., Refshauge, K.M., S\u00e1nchez-Romera, J.F., Pinheiro, M.B., Simpson, S.J., Hopper, J.L., and Ferreira, P.H. (2016). Is Chronic Low Back Pain Associated with the Prevalence of Coronary Heart Disease When Genetic Susceptibility Is Considered? A Co-Twin Control Study of Spanish Twins. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155194"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105725","DOI":"10.1016\/j.clineuro.2020.105725","article-title":"Increased Risk of Strokes in Patients with Chronic Low Back Pain (CLBP): A Nationwide Population-Based Cohort Study","volume":"192","author":"Wang","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s00420-022-01841-z","article-title":"Prevalence of and Factors Associated with Long-Term Sick Leave in Working-Age Adults with Chronic Low Back Pain in Germany","volume":"95","author":"Jacob","year":"2022","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2147\/CEOR.S134130","article-title":"The Economic and Humanistic Costs of Chronic Lower Back Pain in Japan","volume":"9","author":"Montgomery","year":"2017","journal-title":"Clinicoecon. Outcomes Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0304-3959(91)90175-W","article-title":"Prevalence, Onset, and Risk of Psychiatric Disorders in Men with Chronic Low Back Pain: A Controlled Study","volume":"45","author":"Atkinson","year":"1991","journal-title":"Pain"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.spinee.2017.02.009","article-title":"Chronic Low Back Pain and the Risk of Depression or Anxiety Symptoms: Insights from a Longitudinal Twin Study","volume":"17","author":"Fernandez","year":"2017","journal-title":"Spine J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/acr.22619","article-title":"Symptoms of Depression and Risk of New Episodes of Low Back Pain: A Systematic Review and Meta-Analysis","volume":"67","author":"Pinheiro","year":"2015","journal-title":"Arthritis Care Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/01.brs.0000261027.28779.52","article-title":"Do Psychiatric Disorders First Appear Preinjury or Postinjury in Chronic Disabling Occupational Spinal Disorders?","volume":"32","author":"Dersh","year":"2007","journal-title":"Spine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/j.1526-4637.2010.00934.x","article-title":"Psychiatric Disorders and Risk of Transition to Chronicity in Men with First Onset Low Back Pain","volume":"11","author":"Shaw","year":"2010","journal-title":"Pain Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jpain.2017.08.011","article-title":"Previous Mental Disorders and Subsequent Onset of Chronic Back or Neck Pain: Findings from 19 Countries","volume":"19","author":"Viana","year":"2018","journal-title":"J. Pain"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1097\/BRS.0000000000003053","article-title":"Post-Traumatic Stress Disorder Symptoms Are Associated with Incident Chronic Back Pain: A Longitudinal Twin Study of Older Male Veterans","volume":"44","author":"Suri","year":"2019","journal-title":"Spine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/wps.20656","article-title":"Post-Traumatic Stress Disorder: A State-of-the-Art Review of Evidence and Challenges","volume":"18","author":"Bryant","year":"2019","journal-title":"World Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Morris, P., Ali, K., Merritt, M., Pelletier, J., and Macedo, L.G. (2020). A Systematic Review of the Role of Inflammatory Biomarkers in Acute, Subacute and Chronic Non-Specific Low Back Pain. BMC Musculoskelet. Disord., 21.","DOI":"10.1186\/s12891-020-3154-3"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.biopsych.2019.11.005","article-title":"Posttraumatic Stress Disorder and Inflammation: Untangling Issues of Bidirectionality","volume":"87","author":"Sumner","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.amepre.2017.01.040","article-title":"Post-Traumatic Stress Disorder and 20-Year Physical Activity Trends Among Women","volume":"52","author":"Winning","year":"2017","journal-title":"Am. J. Prev. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/ejp.1535","article-title":"Total Physical Activity and Risk of Chronic Low Back and Knee Pain in Middle-Aged and Elderly Japanese People: The Murakami Cohort Study","volume":"24","author":"Solovev","year":"2020","journal-title":"Eur. J. Pain"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/da.22828","article-title":"Posttraumatic Stress Disorder and Cigarette Smoking: A Systematic Review","volume":"35","author":"Kearns","year":"2018","journal-title":"Depress. Anxiety"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e919","DOI":"10.1097\/PR9.0000000000000919","article-title":"Prognostic Factors for Pain Chronicity in Low Back Pain: A Systematic Review","volume":"6","author":"Nieminen","year":"2021","journal-title":"Pain Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.math.2012.10.007","article-title":"Is Alcohol Intake Associated with Low Back Pain? A Systematic Review of Observational Studies","volume":"18","author":"Ferreira","year":"2013","journal-title":"Man. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"110506","DOI":"10.1016\/j.pnpbp.2021.110506","article-title":"Comorbid Alcohol Use and Post-Traumatic Stress Disorders: Pharmacotherapy with Aldehyde Dehydrogenase 2 Inhibitors versus Current Agents","volume":"115","author":"Morice","year":"2022","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/HRP.0000000000000106","article-title":"Posttraumatic Stress Disorder, Overweight, and Obesity: A Systematic Review and Meta-Analysis","volume":"24","author":"Suliman","year":"2016","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/BSD.0000000000000468","article-title":"Obesity as a Risk Factor for Low Back Pain: A Meta-Analysis","volume":"31","author":"Zhang","year":"2018","journal-title":"Clin. Spine Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1001\/jamapsychiatry.2014.2632","article-title":"Posttraumatic Stress Disorder and Incidence of Type 2 Diabetes Mellitus in a Sample of Women: A 22-Year Longitudinal Study","volume":"72","author":"Roberts","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e002426","DOI":"10.1136\/bmjdrc-2021-002426","article-title":"Association between Type 2 Diabetes and Chronic Low Back Pain in General Practices in Germany","volume":"9","author":"Jacob","year":"2021","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"113880","DOI":"10.1016\/j.physbeh.2022.113880","article-title":"Bidirectional Associations between Chronic Low Back Pain and Sleep Quality: A Cohort Study with Schoolteachers","volume":"254","author":"Campanini","year":"2022","journal-title":"Physiol. Behav."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"101623","DOI":"10.1016\/j.smrv.2022.101623","article-title":"Bidirectional Associations between Daily PTSD Symptoms and Sleep Disturbances: A Systematic Review","volume":"63","author":"Slavish","year":"2022","journal-title":"Sleep Med. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"459","DOI":"10.5414\/CP203320","article-title":"Basic Characteristics and Representativeness of the German Disease Analyzer Database","volume":"56","author":"Rathmann","year":"2018","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/07317115.2018.1539801","article-title":"Posttraumatic Stress Disorder in Older Adults: A Conceptual Review","volume":"42","author":"Cook","year":"2019","journal-title":"Clin. Gerontol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/03009742.2016.1218543","article-title":"Chronic Pain in Older Adults: Prevalence, Incidence, and Risk Factors","volume":"46","author":"Larsson","year":"2017","journal-title":"Scand. J. Rheumatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-030-33330-0_3","article-title":"Epidemiology of Frailty in Older People","volume":"1216","author":"Rohrmann","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"943479","DOI":"10.3389\/fpsyg.2022.943479","article-title":"Is Exercise\/Physical Activity Effective at Reducing Symptoms of Post-Traumatic Stress Disorder in Adults\u2014A Systematic Review","volume":"13","author":"Jadhakhan","year":"2022","journal-title":"Front. Psychol."},{"key":"ref_38","first-page":"CD009790","article-title":"Exercise Therapy for Chronic Low Back Pain","volume":"9","author":"Hayden","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/HRP.0000000000000136","article-title":"The Prevalence of Posttraumatic Stress Disorder in Primary Care: A Systematic Review","volume":"25","author":"Spottswood","year":"2017","journal-title":"Harv. Rev. Psychiatry"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/17\/5753\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:46:10Z","timestamp":1760129170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/17\/5753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,4]]},"references-count":39,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["jcm12175753"],"URL":"https:\/\/doi.org\/10.3390\/jcm12175753","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2023,9,4]]}}}