{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:39Z","timestamp":1787028639710,"version":"build-2736575974"},"reference-count":61,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: The use of benzodiazepines for the treatment of acute mania remains prevalent. This systematic review and meta-analysis provides an updated assessment of Clonazepam\u2019s antimanic efficacy, tolerability, and acceptability. (2) Methods: A systematic search of multiple databases and clinical trial registries was conducted, aiming to identify any controlled studies of Clonazepam vs. placebo or any other pharmacotherapy for the treatment of acute mania. Pairwise meta-analytic evaluations were performed. (3) Results: Six studies were included with a total number of 192 participants, all of which were randomized controlled trials. Clonazepam may be superior to a placebo in the acute phase of treatment and no different to Lithium and Haloperidol in terms of efficacy, both acutely and in the medium to long term. Clonazepam may be an acceptable and well-tolerated treatment for acute mania, especially when used as an augmentation strategy. Comparisons were underpowered, with minimal sample sizes and only one study per comparison in many cases, thus limiting the generalizability of our findings and hindering firm clinical conclusions. (4) Conclusions: Given the prevalence of benzodiazepine use in current practice, more and larger studies are urgently needed.<\/jats:p>","DOI":"10.3390\/jcm12185801","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:23:42Z","timestamp":1693995822000},"page":"5801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antimanic Efficacy, Tolerability, and Acceptability of Clonazepam: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Andreas S.","family":"Lappas","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece"},{"name":"Department of Geriatric Psychiatry, Aneurin Bevan University Health Board, Newport NP20 2UB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Helfer","sequence":"additional","affiliation":[{"name":"Meta Research Centre, University of Wroclaw, 50-137 Wroclaw, Poland"},{"name":"Institute of Psychology, University of Wroclaw, 50-527 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4262-0565","authenticated-orcid":false,"given":"Katarzyna","family":"Henke-Ci\u0105\u017cy\u0144ska","sequence":"additional","affiliation":[{"name":"Meta Research Centre, University of Wroclaw, 50-137 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrto T.","family":"Samara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6401-0828","authenticated-orcid":false,"given":"Nikos","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece"},{"name":"Medical School, University of Nottingham, Nottingham NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/S0140-6736(20)31544-0","article-title":"Bipolar disorders","volume":"396","author":"McIntyre","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/bdi.12296","article-title":"Life expectancy in bipolar disorder","volume":"17","author":"Kessing","year":"2015","journal-title":"Bipolar Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.schres.2011.06.008","article-title":"Life expectancy among persons with schizophrenia or bipolar affective disorder","volume":"131","author":"Laursen","year":"2011","journal-title":"Schizophr. 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