{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:24:07Z","timestamp":1793413447066,"version":"4.5.0"},"reference-count":36,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Risk factors associated with severe\u2013critical COVID-19 (coronavirus disease 2019) are based on findings in the general population. Pregnant women are at increased risk of severe\u2013critical infection, and few reports are based on these women. A multicentric case\u2013control study was conducted at the Mexican Institute of Social Security, State of Mexico, during the COVID-19 pandemic. We included pregnant women who were consecutively admitted to respiratory care units and were followed until 30 days after the resolution of pregnancy. A total of 758 pregnant women with a positive RT-PCR test for SARS-CoV-2 were enrolled from June 2020 to July 2021. We defined groups using the World Health Organization Severity Classification; cases were pregnant women with severe\u2013critical COVID-19 (n = 123), and controls were subjects with non-severe COVID-19 (n = 635). Data was gathered from clinical files. A multivariate logistic regression analysis was used to adjust odds ratios and their 95% confidence intervals of factors associated with severe\u2013critical COVID-19. Risk factors associated with severe\u2013critical COVID-19 in pregnancy were non-vaccination (OR 10.18), blood type other than O (OR 6.29), maternal age &gt; 35 years (OR 5.76), history of chronic hypertension (OR 5.12), gestational age at infection \u2265 31 weeks (OR 3.28), and multiparity (OR 2.80).<\/jats:p>","DOI":"10.3390\/jcm12185812","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T10:09:50Z","timestamp":1694081390000},"page":"5812","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Risk Factors for Severe\u2013Critical COVID-19 in Pregnant Women"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0094-1308","authenticated-orcid":false,"given":"Mar\u00eda Guadalupe","family":"Berumen-Lechuga","sequence":"first","affiliation":[{"name":"Medical Research Coordinator, Instituto Mexicano del Seguro Social, \u00d3rgano de Operaci\u00f3n Administrativa Desconcentrada Regional Poniente, Josefa Ortiz de Dom\u00ednguez S\/N Colonia Centro, Toluca CP 50000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8848-5000","authenticated-orcid":false,"given":"Alfredo","family":"Lea\u00f1os-Miranda","sequence":"additional","affiliation":[{"name":"Medical Research Unit in Reproductive Medicine, Instituto Mexicano del Seguro Social, Unidad M\u00e9dica de Alta Especialidad, Hospital de Ginecolog\u00eda y Obstetricia \u201cLuis Castelazo Ayala\u201d, Rio de la Magdalena 289, Tizap\u00e1n San \u00c1ngel, Delegaci\u00f3n \u00c1lvaro Obreg\u00f3n, Ciudad de M\u00e9xico CP 01090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5743-9706","authenticated-orcid":false,"given":"Carlos Jos\u00e9","family":"Molina-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Clinical Coordinator, Instituto Mexicano del Seguro Social, Hospital General de Zona No. 252, Camino Flor de Mar\u00eda y Calzada Se\u00f1or del Huerto 154, Colonia San Mart\u00edn, Atlacomulco CP 54050, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Rey","family":"Garc\u00eda-Cortes","sequence":"additional","affiliation":[{"name":"Medical Research Coordinator, Instituto Mexicano del Seguro Social, \u00d3rgano de Operaci\u00f3n Administrativa Desconcentrada Regional Oriente, Calle 4 No. 25, Fraccionamiento Alce Blanco, Naucalpan CP 53370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Palomo-Pi\u00f1\u00f3n","sequence":"additional","affiliation":[{"name":"Medical Research Unit on Nephrological Diseases (External Collaborator), Instituto Mexicano del Seguro Social, UMAE Centro M\u00e9dico Nacional Siglo XXI, Avenida Cuauht\u00e9moc 330, Colonia Doctores, Ciudad de M\u00e9xico CP 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100107","DOI":"10.1016\/j.ajogmf.2020.100107","article-title":"Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: A systematic review and meta-analysis","volume":"2","author":"Khalil","year":"2020","journal-title":"Am. 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