{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:19:01Z","timestamp":1771571941926,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"INSOFT S.L.\u2019s funds","award":["003\/2023"],"award-info":[{"award-number":["003\/2023"]}]},{"name":"INSOFT S.L.\u2019s funds","award":["2020\/0720\/00098137"],"award-info":[{"award-number":["2020\/0720\/00098137"]}]},{"name":"European Union FEDER funds","award":["003\/2023"],"award-info":[{"award-number":["003\/2023"]}]},{"name":"European Union FEDER funds","award":["2020\/0720\/00098137"],"award-info":[{"award-number":["2020\/0720\/00098137"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Previous retrospective results are evaluated prospectively and blinded. Methods: A total of 221 eyes previously classified as normal (G1), 279 as moderate risk of glaucoma (G2) and 217 as high risk (G3) according to the Globin Discriminant Function (GDF) Laguna-ONhE index were examined with OCT Spectralis- Results: In G1, the Bruch\u2019s Membrane Opening Minimum Rim Width (BMO-MRW) was 332 \u00b1 55 microns; in G2, it was 252 \u00b1 47 (p &lt; 0.0001); and in G3, 231 \u00b1 44 (p &lt; 0.0001). In G1, the 1% and 5% percentiles were 233 and 248, respectively; in G2, they were lower in 28.80% and 42.29% of cases, respectively; and in G3, in 50.23% and 63.59% of cases, respectively. Most of the cases were normal-tension glaucomas. Laguna-ONhE indices showed a curvilinear correlation with BMO-MRW results. The Retinal Nerve Fibre Layer (RNFL) showed a poor relationship with BMO. Assuming G1 to be truly normal, BMO-MRW would have a Receiver operating characteristic (ROC) curve area of 0.901 for G2 and G3 and 0.651 for RNFL. A significant reduction in pixels corresponding to vessels was found in G2 and G3 vs. G1 (p &lt; 0.0001). Conclusions: In some cases, these defects appear to be mainly glaucomatous, and in others, they are associated with diabetic microangiopathy. In normal tension glaucoma, RNFL defects may be less severe than those inside the nerve.<\/jats:p>","DOI":"10.3390\/jcm12185876","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T09:11:18Z","timestamp":1694423478000},"page":"5876","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-5774","authenticated-orcid":false,"given":"Marta","family":"Gonzalez-Hernandez","sequence":"first","affiliation":[{"name":"Instrumentacion y Oftalmologia, INSOFT S.L., 38004 Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9569-2358","authenticated-orcid":false,"given":"Nisamar","family":"Betancor-Caro","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Canarias, 38320 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Mesa-Lugo","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Canarias, 38320 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Rodriguez-Talavera","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Canarias, 38320 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Pareja-Rios","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Canarias, 38320 La Laguna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1984-4919","authenticated-orcid":false,"given":"Isabel","family":"Guedes-Guedes","sequence":"additional","affiliation":[{"name":"Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canarias, Spain"},{"name":"Facultad de Medicina, Universidad de Las Palmas de Gran Canaria, 35001 Las Palmas de Gran, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Estevez-Jorge","sequence":"additional","affiliation":[{"name":"Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canarias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maricela","family":"Trujillo-Blanco","sequence":"additional","affiliation":[{"name":"Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canarias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Cordova-Villegas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canarias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Espinoza-Gonzalez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canarias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Siguero-Martin","sequence":"additional","affiliation":[{"name":"Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canarias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Goya-Gonzalez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canarias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Rodriguez-Dominguez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canarias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7397-7160","authenticated-orcid":false,"given":"Daniel","family":"Gonzalez-Hernandez","sequence":"additional","affiliation":[{"name":"Instrumentacion y Oftalmologia, INSOFT S.L., 38004 Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Gonzalez de la Rosa","sequence":"additional","affiliation":[{"name":"Instrumentacion y Oftalmologia, INSOFT S.L., 38004 Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e001100","DOI":"10.1136\/bmjophth-2022-001100","article-title":"Comparison of age-related vascular changes in the optic disc of patients with diabetes, with glaucomatous and non-glaucomatous features","volume":"7","year":"2022","journal-title":"BMJ Open Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1167\/iovs.12-10761","article-title":"Measuring haemoglobin levels in the optic nerve head: Com-parisons with other structural and functional parameters of glaucoma","volume":"54","author":"Sigut","year":"2013","journal-title":"Investig. 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