{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:23:03Z","timestamp":1775661783812,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ISCIII","award":["19\/00414"],"award-info":[{"award-number":["19\/00414"]}]},{"name":"ERDF, \u201cA way to make Europe\u201d Instituto de Salud Carlos III","award":["19\/00414"],"award-info":[{"award-number":["19\/00414"]}]},{"name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades. Government of Spain","award":["19\/00414"],"award-info":[{"award-number":["19\/00414"]}]},{"name":"Resolution of the Directorate of the Carlos III Health Institute","award":["19\/00414"],"award-info":[{"award-number":["19\/00414"]}]},{"name":"European Regional Development Fund (FEDER)","award":["19\/00414"],"award-info":[{"award-number":["19\/00414"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The 3D-REAL-IR MRI sequence allows for an in vivo visualization of endolymphatic hydrops. Qualitative assessment methods of the severity of vestibular and cochlear hydrops are the most commonly used. Methods: A quantitative volumetric measurement of vestibular EH in patients with definite unilateral M\u00e9ni\u00e8re\u2019s disease using the 3D-REAL-IR sequence and the calculation of the endolymphatic ratio (ELR) was intended. Results: Volumetric calculations of the vestibules, vestibular endolymph and vestibular ELR are performed in 96 patients with unilateral M\u00e9ni\u00e8re\u2019s disease and correlated with classic qualitative grading scales. Conclusions: Quantitative volumetric measurement of vestibular hydrops using the 3D-REAL-IR sequence is feasible and reproducible in daily clinical practice. Vestibular ELR values exceeding 60% defined radiologically significant vestibular hydrops, while values below 30% defined radiologically non-significant vestibular hydrops.<\/jats:p>","DOI":"10.3390\/jcm12185965","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T10:09:22Z","timestamp":1694686162000},"page":"5965","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Magnetic Resonance Volumetric Quantification of Vestibular Endolymphatic Hydrops in Patients with Unilateral Definite Meniere\u2019s Disease Using 3D Inversion Recovery with Real Reconstruction (3D-REAL-IR) Sequence"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7313-4590","authenticated-orcid":false,"given":"V\u00edctor","family":"Su\u00e1rez-Vega","sequence":"first","affiliation":[{"name":"Department of Radiology, Clinica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0781-9679","authenticated-orcid":false,"given":"Raquel","family":"Manrique-Huarte","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Clinica Universidad de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9692-3808","authenticated-orcid":false,"given":"Pablo","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinica Universidad de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Clinica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Alonso-Burgos","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1192-5901","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"P\u00e9rez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Clinica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.otc.2010.05.001","article-title":"Current Epidemiology of Meniere\u2019s Syndrome","volume":"43","author":"Alexander","year":"2010","journal-title":"Otolaryngol. 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