{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:40:33Z","timestamp":1793497233168,"version":"4.5.0"},"reference-count":37,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study aimed to explore the potential association between the triglyceride\u2013glucose index (TyG) and the atherogenic index of plasma (AIP)\u2014both considered surrogate markers for atherosclerosis\u2014and major adverse cardiovascular events (MACEs) in patients diagnosed with chronic coronary syndrome (CCS). We conducted a retrospective analysis, encompassing 715 consecutive patients with intermediate CCS risk, who presented at the outpatient clinic between June 2020 and August 2022. MACEs included non-fatal myocardial infarction, hospitalization for heart failure, cerebrovascular events, non-cardiac mortality, and cardiac mortality. The primary outcome was the composite occurrence of MACEs during the follow-up period. For time-to-event analysis of the primary outcome, we employed Kaplan\u2013Meier plots and Cox proportional hazard models. The median age of the overall study population was 55 years, with a median follow-up duration of 17 months. Multivariate Cox regression analysis identified age, hypertension, Coronary Artery Disease\u2013Reporting and Data System score, and TyG index as independent predictors of the primary outcome. Notably, individuals with high TyG levels exhibited a significantly higher primary outcome rate compared to those with low TyG levels (18.7% vs. 3.8%, p &lt; 0.001). Similarly, patients with elevated TyG values demonstrated statistically higher rates of cerebrovascular events, hospitalizations for heart failure, non-fatal myocardial infarctions, non-cardiac mortality, and cardiac mortality. These findings suggest that TyG may serve as a predictive marker for adverse cardiovascular outcomes in patients with CCS.<\/jats:p>","DOI":"10.3390\/jcm12196201","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T03:45:23Z","timestamp":1695699923000},"page":"6201","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Triglyceride\u2013Glucose Index Might Be a Better Indicator for Predicting Poor Cardiovascular Outcomes in Chronic Coronary Syndrome"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1094-5572","authenticated-orcid":false,"given":"Aslan","family":"Erdo\u011fan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Basaksehir Cam & Sakura City Hospital, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3921-6469","authenticated-orcid":false,"given":"Duygu","family":"\u0130nan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Basaksehir Cam & Sakura City Hospital, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-5391","authenticated-orcid":false,"given":"\u00d6mer","family":"Gen\u00e7","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Basaksehir Cam & Sakura City Hospital, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-4293","authenticated-orcid":false,"given":"Ufuk","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Basaksehir Cam & Sakura City Hospital, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4846-0770","authenticated-orcid":false,"given":"Ay\u015fe \u0130rem","family":"Demirtola","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Basaksehir Cam & Sakura City Hospital, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0331-9167","authenticated-orcid":false,"given":"\u0130lyas","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Basaksehir Cam & Sakura City Hospital, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-3966","authenticated-orcid":false,"given":"Yeliz","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Basaksehir Cam & Sakura City Hospital, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-9314","authenticated-orcid":false,"given":"Ali Fuat","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Basaksehir Cam & Sakura City Hospital, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2666-4983","authenticated-orcid":false,"given":"S\u00fcleyman","family":"Barut\u00e7u","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Basaksehir Cam & Sakura City Hospital, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0324-1200","authenticated-orcid":false,"given":"Ahmet","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Basaksehir Cam & Sakura City Hospital, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-2021","authenticated-orcid":false,"given":"Ali","family":"Karag\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kartal Kosuyolu Education and Training Hospital, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"ref_1","first-page":"284","article-title":"Stable coronary syndromes: Pathophysiology, diagnostic advances and therapeutic need","volume":"104","author":"Ford","year":"2018","journal-title":"Heart"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.2538","article-title":"Atherosclerosis: Current pathogenesis and therapeutic options","volume":"17","author":"Weber","year":"2011","journal-title":"Nat. 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