{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:55:59Z","timestamp":1768272959840,"version":"3.49.0"},"reference-count":23,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Childhood glaucoma is one of the most common causes of corneal opacity in childhood and is associated with various pathological corneal changes, including corneal enlargement, corneal clouding, and edema. Congenital glaucoma (CG) may cause a decrease in vision outcomes due to corneal opacity or clouding, which is often associated with stimulus deprivation amblyopia. Therefore, to create a balance between preventing amblyopia and sustaining corneal clearance, patients with CG can be managed with early penetrating corneal transplantation surgery along with advanced glaucoma management. Aim: To investigate the graft survival rate and factors affecting graft survival in patients with congenital glaucoma who underwent penetrating keratoplasty (PKP). Study Design: Cross-sectional. Materials and Methods: Patients with congenital glaucoma who underwent PKP were retrospectively evaluated. The associations between age, corneal diameter, presence of ocular comorbidities, concurrent ocular surgeries with corneal graft, and visual outcomes were assessed. Results: Among the 30 eyes enrolled in the study, 6 (20%) had aniridia, 6 (20%) had Axenfeld\u2013Rieger syndrome, and 18 (60%) were diagnosed with primary congenital glaucoma. Graft survival rates were 66.6% and 63.33% at 12 and 24 months, respectively. At the end of the follow-up, the overall graft survival rate was 60%. Statistical significance was observed between patient age at the time of surgery and graft failure (p = 0.02). Graft failure was associated with a younger patient age. Functional vision was achieved in 53.3% of patients. Conclusions: The management of congenital glaucoma and its corneal complications is a delicate issue that requires great effort. PKP in congenital glaucoma was moderately successful in the present study. To provide functional vision, PKP could be the treatment of choice.<\/jats:p>","DOI":"10.3390\/jcm12196276","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:48:13Z","timestamp":1695966493000},"page":"6276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Penetrating Keratoplasty in Congenital Glaucoma"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-2577","authenticated-orcid":false,"given":"Bilge","family":"Batu Oto","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Cerrahpa\u015fa Medical Faculty, Istanbul University-Cerrahpa\u015fa, 34098 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevbahar","family":"Tam\u00e7elik","sequence":"additional","affiliation":[{"name":"Tamcelik Glaucoma Center, 34394 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erc\u00fcment","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bat\u0131 G\u00f6z Merkezi, 34662 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceyhun","family":"Arici","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cerrahpa\u015fa Medical Faculty, Istanbul University-Cerrahpa\u015fa, 34098 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O\u011fuzhan","family":"K\u0131l\u0131\u00e7arslan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ayanc\u0131k State Hospital, 57400 Sinop, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Busenur","family":"G\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zonguldak Atat\u00fcrk State Hospital, 67030 Zonguldak, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hac\u0131 U\u011fur","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Flaum Eye Institute, School of Medicine and Dentistry, University of Rochester, New York, NY 14627, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/ICO.0000000000001695","article-title":"Indications and Outcomes of Penetrating Keratoplasty in Infants and Children of Beijing, China","volume":"37","author":"Zhang","year":"2018","journal-title":"Cornea"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00004397-197501510-00004","article-title":"Fine structure of the developing cornea","volume":"15","author":"Zinn","year":"1975","journal-title":"Int. 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