{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:33:41Z","timestamp":1760150021479,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Blood gas analysis is part of the diagnostic work\u2212up for pulmonary hypertension (PH). Although some studies have found that the partial pressure of carbon dioxide (PaCO2) is an independent marker of mortality in individuals with pulmonary arterial hypertension (PH Group 1), there is a lack of data regarding the significance of PaCO2 in individuals with different types of PH based on the new 2022 definitions. Therefore, this study analyzed data from 157 individuals who were undergoing PH work\u2212up, including right heart catheterization, using PH definitions from the 2022 European Society of Cardiology\/European Respiratory Society guidelines. At diagnosis, N\u2212terminal pro\u2212B\u2212type natriuretic peptide (NT\u2212pro\u2212BNP) levels were significantly higher, but the time\u2212course of NT\u2212pro\u2212BNP levels during treatment was significantly more favorable in individuals with pulmonary arterial hypertension (PH Group 1) who did versus did not have hypocapnia (p = 0.026 and p = 0.017, respectively). These differences based on the presence of hypocapnia were not seen in individuals with PH Groups 2, 3, or 4. In conclusion, using the new definition of PH, hypocapnia may correlate with worse risk stratification at diagnosis in individuals with pulmonary arterial hypertension. However, hypocapnic individuals with pulmonary arterial hypertension may benefit more from disease\u2212specific therapy than those without hypocapnia.<\/jats:p>","DOI":"10.3390\/jcm12196307","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:28:08Z","timestamp":1696220888000},"page":"6307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Significance of Hypocapnia in the Risk Assessment of Patients with Pulmonary Hypertension"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4920-4107","authenticated-orcid":false,"given":"Maria","family":"Aetou","sequence":"first","affiliation":[{"name":"Department of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lora","family":"Wahab","sequence":"additional","affiliation":[{"name":"Department of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3452-5329","authenticated-orcid":false,"given":"Michael","family":"Dreher","sequence":"additional","affiliation":[{"name":"Department of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2088-8129","authenticated-orcid":false,"given":"Ayham","family":"Daher","sequence":"additional","affiliation":[{"name":"Department of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e029024","DOI":"10.1161\/JAHA.122.029024","article-title":"Revised Definition of Pulmonary Hypertension and Approach to Management: A Clinical Primer","volume":"12","author":"Maron","year":"2023","journal-title":"J. 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